• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia
LeadershipLeadership

The Fortune 500 is built on more than money. It’s built on human, social, and natural capital, too

By
Andre Hoffmann
Andre Hoffmann
and
Peter Vanham
Peter Vanham
Down Arrow Button Icon
By
Andre Hoffmann
Andre Hoffmann
and
Peter Vanham
Peter Vanham
Down Arrow Button Icon
September 6, 2024, 12:52 PM ET
Roche grew into a pharma giant by relying on the social, natural, and human capital of the city of Basel.
Roche grew into a pharma giant by relying on the social, natural, and human capital of the city of Basel.GABRIEL MONNET - AFP - Getty Images

My great-grandfather, Fritz Hoffmann-La Roche, was a visionary entrepreneur. From 1896, he pioneered the nascent pharmaceutical industry, overcoming countless hurdles and challenges. By the time he died, he had built a multinational organization that still operates today as one of the largest pharmaceutical companies in the world: Roche.

I love to look back on this story. And yet there’s a problem with it. This story is too centered on the achievements of one person.

We often hear business success is the result of individual genius, entrepreneurship, and persistence. We know this myth not just from my great-grandfather but also from some of the world’s richest men of today, such as Elon Musk, Mark Zuckerberg, and other Silicon Valley luminaries.

But these mythologies, just like my great-grandfather’s, are misleading. Not factually, but they miss the bigger picture.

Fritz Hoffmann-La Roche was exactly as I just described. But he was also a child of his time and the world around him. To succeed, he could bank on several “capitals” that were uniquely available to him. These included the financial capital, which was given to him by his father, father-in-law, and other family members and associates. And they included social, natural, and human capital, all available in Basel, the city on the Rhine River where Fritz lived.

Social capital

When recounting the story of successful founders and companies, we tend to brush over fundraising as if it comes naturally. But getting access to it depends as much on one’s network as on one’s business ideas. Take Mark Zuckerberg, for example. In early 2004, Facebook received its first funding of $500,000 barely three months after its incorporation in a Harvard dorm room, and less than a year after the project was conceived. The money came from PayPal cofounder and venture capital investor Peter Thiel. A similar story played out at Google, Amazon, or Apple.

That immediately raises a second question: Where does financial capital come from? In the case of my great-grandfather and great-grandmother, their money came from the Daig families who controlled much of Basel’s economic development since medieval times and were an important constituent of Basel’s social capital. But if my great-grandparents succeeded in creating Roche, it was also in large part thanks to the city’s social capital. Fritz could acquire land near the city, hire both skilled and unskilled labor, and insert his new company in the trade and finance links the city had with the outside world, thanks to the social capital present in the city and his access to it.

Today’s leading entrepreneurs built their success in a similar way. They had access to similar networks and lived and worked in regions with an abundance of social capital.

The founders of Apple could lean on a former Intel employee for their seed capital, and took a page from a nearby company—Hewlett Packard—to start up their company from a garage. At Google, Larry Page and Sergey Brin stormed the tech scene in the 1990s, after having had their beginnings at Stanford University. As for Facebook, the network was made up of Harvard students, allowing it to lean on the social capital of the university. To become the company Meta is today, Zuckerberg also tapped into the social of Silicon Valley. Finally, when Jeff Bezos was considering where best to build Amazon, Seattle had already been transformed by Microsoft’s presence.

Natural capital

The most important natural capital is the natural inputs that go into their products (a company’s nature-related “dependencies”) and the effect their sold products have on the environment (nature-related “impacts”).

Roche has been producing Tamiflu since the late 1990s, generating billions of dollars in sales. At the origin of Tamiflu of course, an antiviral medicine to treat the flu and other influenza viruses, lies a costly research and development effort, in this case from Roche’s U.S. partner Gilead Sciences. But Tamiflu also has a very natural key ingredient: shikimic acid, harvested from the star anise flower, native to Vietnam and Southern China. The same is true for many other drugs and medicinal products, and not just herbal ones.

Nature is a crucial building block, or dependency, for virtually any company. Even the world’s most valuable company in 2024, Nvidia, could not make what it sells without silica, glass, aluminum, and copper, to name just a few of the inputs that go into its powerful GPU processors which power the most hyped technology of our time: AI.

Human capital

Human capital is about the individual talents and skills of the people who work in your organization. It is about a great manager, an inventive researcher, a talented sales representative, a factory worker with an eye for detail. My great-grandfather, and every generation of owners of Roche since, could count on each one of those, and more.

Roche became a better employer because of the Roche union. Today, more than 60% of Roche employees are members of the Roche Employees’ Association union. The union weighs in on salary policies, employee-friendly working arrangements, and aims to secure Basel as an industrial base. And it represents employees on investments committees, the employee profit-sharing and pension committees, and the safety and environmental protection committee.

I share the story of the “capitals” because they matter. Roche became the leading pharmaceutical firm it is today thanks to them. They are the foundations on which entire capitalist economies and societies are built, I would even say.

But if these capitals are not acknowledged, or even taken for granted, problems emerge. These capitals, like financial capital, can either grow or decline over time. Whether they do, and to what extent, depends on the contributions we all make to them, whether we accumulate capital, or spend them.

There is something quite special about natural, social, environmental, and human capital. They are valuable to all of us, so it is up to each of us to leave them in a better state than we found them. But they are vulnerable, and can be extracted, so we’ll always be tempted to consume them for our own benefit, rather than to invest in them. We must no longer let that happen going forward.

Adapted with permission from the publisher, Wiley, from The New Nature of Business: The Path to Prosperity and Sustainability by André Hoffmann and Peter Vanham. Copyright © 2024 by André Hoffmann and Peter Vanham. All rights reserved. This book is available wherever books and eBooks are sold.

Join us at the Fortune Workplace Innovation Summit May 19–20, 2026, in Atlanta. The next era of workplace innovation is here—and the old playbook is being rewritten. At this exclusive, high-energy event, the world’s most innovative leaders will convene to explore how AI, humanity, and strategy converge to redefine, again, the future of work. Register now.
About the Authors
By Andre Hoffmann
See full bioRight Arrow Button Icon
By Peter VanhamEditorial Director, Leadership
LinkedIn icon

Peter Vanham is editorial director, leadership, at Fortune.

See full bioRight Arrow Button Icon

Latest in Leadership

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025

Most Popular

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • Future 50
  • World’s Most Admired Companies
  • See All Rankings
Sections
  • Finance
  • Leadership
  • Success
  • Tech
  • Asia
  • Europe
  • Environment
  • Fortune Crypto
  • Health
  • Retail
  • Lifestyle
  • Politics
  • Newsletters
  • Magazine
  • Features
  • Commentary
  • Mpw
  • CEO Initiative
  • Conferences
  • Personal Finance
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
About Us
  • About Us
  • Editorial Calendar
  • Press Center
  • Work At Fortune
  • Diversity And Inclusion
  • Terms And Conditions
  • Site Map
  • Facebook icon
  • Twitter icon
  • LinkedIn icon
  • Instagram icon
  • Pinterest icon

Most Popular

placeholder alt text
Economy
Elon Musk warns the U.S. is '1,000% going to go bankrupt' unless AI and robotics save the economy from crushing debt
By Jason MaFebruary 7, 2026
1 day ago
placeholder alt text
Success
Gen Z Patriots quarterback Drake Maye still drives a 2015 pickup truck even after it broke down on the highway—despite his $37 million contract
By Sasha RogelbergFebruary 7, 2026
2 days ago
placeholder alt text
Success
Even with $850 billion to his name, Elon Musk admits ‘money can’t buy happiness.’ But billionaire Mark Cuban says it’s not so simple
By Preston ForeFebruary 6, 2026
2 days ago
placeholder alt text
Future of Work
Anthropic cofounder says studying the humanities will be 'more important than ever' and reveals what the AI company looks for when hiring
By Jason MaFebruary 7, 2026
1 day ago
placeholder alt text
Economy
Russian officials are warning Putin that a financial crisis could arrive this summer, report says, while his war on Ukraine becomes too big to fail
By Jason MaFebruary 8, 2026
7 hours ago
placeholder alt text
Commentary
America marks its 250th birthday with a fading dream—the first time that younger generations will make less than their parents
By Mark Robert Rank and The ConversationFebruary 8, 2026
15 hours ago

© 2026 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.


Latest in Leadership

EconomyUkraine invasion
Russian attacks on Ukraine’s energy infrastructure are the biggest threat to its economy, which could shrink as much as 3%
By Kamila Hrabchuk and The Associated PressFebruary 8, 2026
12 hours ago
C-SuiteMedia
Washington Post publisher to step down after big layoffs as union calls his legacy ‘attempted destruction of a great American journalism institution’
By David Bauder and The Associated PressFebruary 8, 2026
12 hours ago
Tom Brady looks on prior to the game at AT&T Stadium on September 15, 2024 in Arlington, Texas.
Personal FinanceNFL
Tom Brady is making 15 times more as a Super Bowl commentator than he did playing in the big game thanks to $375 million contract 
By Eva RoytburgFebruary 8, 2026
14 hours ago
tipping
CommentaryTipping
I’m the chief growth officer at a payments app and I know how America really tips. Connecticut, I’m looking at you
By Ricardo CiciFebruary 8, 2026
14 hours ago
heacock
CommentaryLeadership
I’m a CEO who grew a ‘boring’ air filter business into a $260 million company, and AI is going to help blue-collar, everyday people just like me
By David HeacockFebruary 8, 2026
14 hours ago
Joanna Griffiths, the founder and president of Knix
SuccessEntrepreneurs
The founder of $400 million company Knix sees a hypnotherapist to ‘rewire’ her brain and work through her fear of failure
By Emma BurleighFebruary 8, 2026
15 hours ago