• Home
  • News
  • Fortune 500
  • Tech
  • Finance
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia
FinanceFortune 500

Apple was the most profitable company on the Fortune 500 list this year. These are the biggest profit generators, and what that means about American business.

Will Daniel
By
Will Daniel
Will Daniel
Down Arrow Button Icon
Will Daniel
By
Will Daniel
Will Daniel
Down Arrow Button Icon
May 24, 2022, 2:05 PM ET

American companies had a huge year in 2021. 

Together, the corporations on this year’s Fortune500 list generated a record $1.8 trillion in profits on $16.1 trillion in revenue. 

The story of the top 10 most profitable U.S. companies reveals some major trends in the current American business landscape: Tech continues to dominate, energy companies remain in a secular decline despite a rebound in 2021, and a strong economy lifts all boats. 

Techremains dominant

Apple once again took the top spot on Fortune’s list of the most profitable American companies in 2021. The tech giant raked in $94.7 billion in profits last year on revenues of $365.8 billion.

In the past, oil producers and even car companies like Ford were common sights at the top of the most profitable companies list, but these days, tech companies reign supreme. Tech giants represented three out of the top five most profitable companies in the U.S. in 2021 and half of the top 10.

Apple has also taken the top spot on the Fortune 500 most profitable list for seven out of the last eight years, only being eclipsed once by Warren Buffet’s Berkshire Hathaway in 2019.

Other tech profit generators in the top ten included Meta Platforms, Amazon, Microsoft, and Google’s parent company Alphabet.

Fossil fuel’s secular decline continues

The waning dominance of fossil fuel companies has been an ongoing trend over the past decade, and only one company, Exxon Mobil, nabbed a top spot in the most profitable list. 

But that doesn’t tell the whole story. 

Rising oil and gas prices lifted many energy companies to new heights in 2021, increasing the sector’s presence in this year’s Fortune 500. 

Still, from 2000 to 2015, Exxon Mobil earned the top spot as the most profitable U.S. firm 12 times, while this year it only managed the number nine slot. It was also the only company that didn’t post a double-digit year-over-year increase in profits compared to 2020.

A strong economy lifts banks, mortgage lenders

A strong economy and a record year for stocks meant big business for America’s banks and investment managers in 2021. 

U.S. banks pulled in $279.1 billion in profits last year, a $132 billion jump compared with 2020, FDIC data shows. Both JP Morgan Chase and Bank of America made it on this year’s top 10 most profitable U.S. firms list, while Citigroup, Goldman Sachs, and Wells Fargo came in at the 13th, 14th, and 15th spots, respectively.

Low-interest rates and a strong housing market in 2021 also pushed the Federal National Mortgage Association, a.k.a Fannie Mae, into the list of most profitable firms. The mortgage lender nearly doubled its profits compared to 2020 as the red-hot housing market raged, but with the market showing signs of a slowdown as mortgage rates rise, 2022 may be a different story.

Finally, Warren Buffet’s Berkshire Hathaway saw a record year in 2021, bolstered by rising stock prices in two of its largest holdings, Apple and Bank of America. Increasing profits in the conglomerate’s railroad, utilities and energy businesses and a turnaround in its insurance-underwriting operations also helped boost results.

Here’s a look at the top 10 most profitable firms in the U.S.

Apple

Revenue: $365.8 billion

Profit: $94.7 billion

Year-over-year change in profit: 64.9%

Berkshire Hathaway

Revenue: $276.1 billion

Profit: $89.8 billion

Year-over-year change in profit: 111.2%

Alphabet

Revenue: $257.6 billion

Profit: $76 billion

Year-over-year change in profit: 88.8%

Microsoft

Revenue: $168.1 billion

Profit: $61.3 billion

Year-over-year change in profit: 38.4%

JP Morgan Chase

Revenue: $127.2 billion

Profit: $48.3 billion

Year-over-year change in profit: 65.9%

Meta Platforms

Revenue: $117.9 billion

Profit: $39.4 billion

Year-over-year change in profit: 35.1%

Amazon

Revenue: $469.8

Profit: $33.4 billion

Year-over-year change in profit: 56.4%

Bank of America

Revenue: $93.8 billion

Profit: $32 billion

Year-over-year change in profit: 78.7%

Exxon Mobil

Revenue: $285.6 billion

Profit: $23 billion

Fannie Mae

Revenue: $101.5 billion

Profit: $22.2 billion

Year-over-year change in profit: 87.9%

Sign up for the Fortune Features email list so you don’t miss our biggest features, exclusive interviews, and investigations.

About the Author
Will Daniel
By Will Daniel
LinkedIn iconTwitter icon
See full bioRight Arrow Button Icon

Latest in Finance

Personal FinanceCertificates of Deposit (CDs)
Best certificates of deposit (CDs) for December 2025
By Glen Luke FlanaganDecember 4, 2025
1 hour ago
The Fifth Third Bank logo on a blue and purple layered background.
Personal Financechecking accounts
Fifth Third Bank review 2025: Full-service bank with unique perks (but lackluster APYs)
By Joseph HostetlerDecember 4, 2025
1 hour ago
Trump
PoliticsWhite House
‘We fixed inflation, and we fixed almost everything’: Trump travels to Pennsylvania to talk affordability while denying it’s a problem
By Josh Boak and The Associated PressDecember 4, 2025
1 hour ago
Bear
RetailTariffs and trade
Build-A-Bear stock falls 15% as it reveals the real hit from tariffs, at last
By Michelle Chapman and The Associated PressDecember 4, 2025
2 hours ago
Gen Z
EconomyGen Z
America, meet your alienated youth: ‘Gold standard’ Harvard survey reveals Gen Z’s anxiety and distrust, defined by economic insecurity
By Nick LichtenbergDecember 4, 2025
2 hours ago
The outside of a Dollar General store, at night
Retaildollar stores
Rich people are flooding dollar stores as Americans navigate a crushing affordability crisis
By Dave SmithDecember 4, 2025
4 hours ago

Most Popular

placeholder alt text
Economy
Two months into the new fiscal year and the U.S. government is already spending more than $10 billion a week servicing national debt
By Eleanor PringleDecember 4, 2025
11 hours ago
placeholder alt text
North America
Jeff Bezos and Lauren Sánchez Bezos commit $102.5 million to organizations combating homelessness across the U.S.: ‘This is just the beginning’
By Sydney LakeDecember 2, 2025
2 days ago
placeholder alt text
Success
‘Godfather of AI’ says Bill Gates and Elon Musk are right about the future of work—but he predicts mass unemployment is on its way
By Preston ForeDecember 4, 2025
6 hours ago
placeholder alt text
Economy
Ford workers told their CEO 'none of the young people want to work here.' So Jim Farley took a page out of the founder's playbook
By Sasha RogelbergNovember 28, 2025
6 days ago
placeholder alt text
North America
Anonymous $50 million donation helps cover the next 50 years of tuition for medical lab science students at University of Washington
By The Associated PressDecember 2, 2025
2 days ago
placeholder alt text
Health
Bill Gates decries ‘significant reversal in child deaths’ as nearly 5 million kids will die before they turn 5 this year
By Nick LichtenbergDecember 4, 2025
18 hours ago
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • Future 50
  • World’s Most Admired Companies
  • See All Rankings
Sections
  • Finance
  • Leadership
  • Success
  • Tech
  • Asia
  • Europe
  • Environment
  • Fortune Crypto
  • Health
  • Retail
  • Lifestyle
  • Politics
  • Newsletters
  • Magazine
  • Features
  • Commentary
  • Mpw
  • CEO Initiative
  • Conferences
  • Personal Finance
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
About Us
  • About Us
  • Editorial Calendar
  • Press Center
  • Work At Fortune
  • Diversity And Inclusion
  • Terms And Conditions
  • Site Map

© 2025 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.