• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia
RetailWhiskey

Is Molecular Whiskey the Futuristic Booze We’ve Been Waiting For?

By
Billy Lyons
Billy Lyons
Down Arrow Button Icon
By
Billy Lyons
Billy Lyons
Down Arrow Button Icon
May 25, 2019, 9:30 AM ET
Endless West-Whiskey Lab
Glyph cocktails by Westlight at The William Vale Hotel photography by Kris TurnerPhotograph by Kris Turner

Tasting whiskey usually means enjoying flavors created from the interaction between spirit and barrel over an extended period of time. However, some companies are rethinking this traditional narrative.

Endless West, a San Francisco-based startup, recently launched a spirit made without the use of tried and true techniques, like barrel aging, in a process the company labels note-by-note production. Billed as the world’s first “molecular whiskey,” Glyph is not just a symbol of what happens when science, alcohol, and ambition meet, but what might attract future generations of drinkers to the products they purchase. But what does whiskey made in a lab actually involve?

At Endless West, note-by-note production is a three-stage process, beginning with mapping the molecules that give fine whiskeys their unique tasting profiles. To do this, their team studies the molecules found in currently available whiskey and spirits, analyzing what characteristics differentiate one whiskey from another.

Once specific molecules are identified, the next phase is locating and acquiring them in their purest forms, such as sugar from corn or esters from fruit. Everything is sourced naturally from plants, yeasts, and fruits as opposed to using artificial ingredients.

The final step involves using the chosen molecules along with a neutral grain spirit as a base to build the flavor profile of a whiskey.

Endless West-Whiskey Lab
Glyph cocktails by Westlight at The William [hotlink]Vale[/hotlink] Hotel in New York.Photograph by Grace Rivera
Photograph by Grace Rivera

“It’s important to emphasize that everything we make is our own original recipe. Using our note-by-note production process, we can make Glyph in under 24 hours or overnight,” says Endless West CEO and co-founder Alec Lee. The idea of being able to produce a whiskey in 24 hours that could match the flavor profile of a 24-year-old aged whiskey might seem outrageous, but it’s that question of “what if” that tends to drive most innovations.

“The reality is that most spirit and winemaking processes are pretty inefficient, especially when you consider the requirements for aging,” says Lee. “We’re simply making a statement that you can reimagine this traditional product in a new way and certain cost, time, and sustainability advantages happen to come with it.”

With an increasing demand for companies across industries to practice and preach sustainable production methods, a voice offering an alternative to sacred distilling traditions is intriguing enough to attract investors, industry professionals, and hopefully, consumers. “The single most important clarification here is how sustainability isn’t the central thesis of our appeal,” Lee says. “The central thesis is the ability to create an age old product that we know and love using a radically different medium that is inherently more efficient.”

Mixed Results

From the scientific perspective, the premise that the molecules found in aged whiskey can be found throughout nature is valid enough for individuals to conduct experimentation. However, despite years of studying, making, and drinking whiskey, humans still have work to do when it comes to understanding whiskey’s DNA.

“The problem with saying ‘we analyzed whiskey down to the molecular level and reconstructed a new whiskey based on that information’ is that the complexity of whiskey is even to this day poorly understood,” says Dr. Pat Heist, co-founder and chief scientific officer for Wilderness Trail Distillery and Ferm Solutions, Inc. “There are likely chemicals in there that you can taste, but that are in levels so minute that they can’t be picked up by even the most sophisticated chemical analysis.”

Endless West-Whiskey Lab
Glyph whiskey at the William Vale Hotel in New York. Photograph by Grace Rivera
Photograph by Grace Rivera

As with any new product making its debut in the industry, opinions have varied. “I love science and innovation, so I’m not as opposed to the existence of products like this as most of my colleagues, but it’s hardly equal to whiskey. It’s a whiskey substitute,” says drinks writer Camper English of Alcademics.com. English first tasted Glyph as a judge in a blind tasting at the industry renowned San Francisco World Spirits Competition. That same competition awarded Glyph a silver medal in 2019, which the organization defines as “outstanding spirits that show refinement, finesse, and complexity,” in its Other Miscellaneous Spirits category.

“It’s not a world that really rewards the new kid on the block,” says Fred Minnick, author of Bourbon: The Rise, Fall, and Rebirth of an American Whiskey. Minnick notes that Lost Spirits in California was one company he knew of that’s been able to produce rapid-aging rums and whiskies using proprietary technology, but few have found long-term success when it comes to cheating Father Time.

An Acquired Taste

Like any scientific experiment, there can always be unintended consequences. For some industry experts, there are good reasons as to why lab made whiskey doesn’t work for them. “Whiskey is an American heritage product that needs to be respected. Is building a liquid in a lab going to employ hundreds of people to make it and stimulate a local economy? Nope. Just because you can apply technology to something it doesn’t necessarily improve it,“ says Francine Cohen, founder of trade industry magazine and strategic brand consultancy Insidefandb.com. Though Cohen was not moved by her initial tasting of Glyph, she did indicate she would sample Glyph again if improvements were made from its original formula.

While Glyph, like traditionally produced whiskies, may not win over every palate in the industry, challenging the way consumers think about alcohol production demonstrates the widespread appeal making spirits has had from generation to generation. Though the age of a guest self-identifying as a molecular whiskey drinker may never come to fruition, the use of Glyph for cocktails might turn out to be the sturdiest bridge that connects this company to consumers.

Endless West-Whiskey Lab
Glyph cocktail at the William Vale Hotel in New York.Photograph by Grace Rivera
Photograph by Grace Rivera

Glyph already has an in-house mixologist creating original cocktail recipes, and the product is available in New York and California. “I love trying new spirits and cocktails so I would absolutely try it in a cocktail if I saw it on a bar menu. Why not?” English admits.

If the story of whiskey to this point has been a lesson on the virtues of patience and trusting the process created by professional distillers, the next chapter might focus on customization and what can happen when modern technology and outside-the-box experimentation mix. Though traditional practices will always be revered, the ability to apply new learnings in order to create perspective is something that’s always worth discussing and testing out—especially when drinks are involved.

More must-read stories from Fortune:

—Why liquor makers are promoting cocktails over shots

—Know what to look for to find a great bottle of rosé

—Move over Bourbon, premium rum wants its turn in the spotlight

—Canned wines are on the rise and perfect for this summer. Here are the ones you should try

—Listen to our new audio briefing, Fortune 500 Daily

Follow Fortune on Flipboard to stay up-to-date on the latest news and analysis.

About the Author
By Billy Lyons
See full bioRight Arrow Button Icon

Latest in Retail

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025

Most Popular

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • Future 50
  • World’s Most Admired Companies
  • See All Rankings
Sections
  • Finance
  • Leadership
  • Success
  • Tech
  • Asia
  • Europe
  • Environment
  • Fortune Crypto
  • Health
  • Retail
  • Lifestyle
  • Politics
  • Newsletters
  • Magazine
  • Features
  • Commentary
  • Mpw
  • CEO Initiative
  • Conferences
  • Personal Finance
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
About Us
  • About Us
  • Editorial Calendar
  • Press Center
  • Work At Fortune
  • Diversity And Inclusion
  • Terms And Conditions
  • Site Map
  • Facebook icon
  • Twitter icon
  • LinkedIn icon
  • Instagram icon
  • Pinterest icon

Most Popular

placeholder alt text
Europe
Denmark offered to trade Greenland to the U.S. in 1910—and America thought it was crazy
By Steven Lamy and The ConversationJanuary 22, 2026
3 days ago
placeholder alt text
North America
Gates Foundation plans to give away $9 billion in 2026 to prepare for the 2045 closure while slashing hundreds of jobs
By Sydney LakeJanuary 23, 2026
2 days ago
placeholder alt text
Personal Finance
Sweden abolished its wealth tax 20 years ago. Then it became a 'paradise for the super-rich'
By Miranda Sheild Johansson and The ConversationJanuary 22, 2026
3 days ago
placeholder alt text
C-Suite
Jamie Dimon’s reality check for ambitious workers: ‘There’s going to be a grunt part to every part of a job. Get over it’
By Jake AngeloJanuary 23, 2026
2 days ago
placeholder alt text
Energy
Elon Musk warns the U.S. could soon be producing more chips than we can turn on. And China doesn’t have the same issue
By Sasha RogelbergJanuary 22, 2026
3 days ago
placeholder alt text
Politics
Latest deadly shooting by federal agents pushes government closer to shutdown as Trump claims Minnesota officials are 'inciting insurrection'
By Jason MaJanuary 24, 2026
11 hours ago

© 2026 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.


Latest in Retail

A woman stands in a target with her fist in the air. A man behind her holds an "Abolish ICE" sign.
RetailTarget
Target faces new backlash amid Minnesota ICE raids after boycotts over its DEI rollback. But don’t blame politics for falling profits, analyst says
By Jacqueline MunisJanuary 23, 2026
2 days ago
RetailWeather and forecasting
How Walmart is using AI to reroute essential supplies ahead of Winter Storm Fern
By Alex Vuocolo and Retail BrewJanuary 23, 2026
2 days ago
Walmart's CEO Doug McMillon
Successchief executive officer (CEO)
Walmart CEO started his career unloading trailers at the warehouse. He says he got promotion after promotion by raising his hand when his boss was out
By Orianna Rosa RoyleJanuary 23, 2026
2 days ago
EuropeDonald Trump
A Danish app that helps consumers boycott U.S. products increased users by 1,400% as Trump resurrected the Greenland issue at Davos
By Marco Quiroz-GutierrezJanuary 23, 2026
2 days ago
C-SuiteFortune 500
The Walmart C-suite reshuffle shows how the retailer sees itself now: As a tech company
By Phil WahbaJanuary 21, 2026
4 days ago
nathan's
BankingFood and drink
Nathan’s Famous goes from 5-cent hot dog stand in Coney Island to $450 million acquisition by Smithfield Foods over 100 years later
By Matt Ott and The Associated PressJanuary 21, 2026
4 days ago