The 7 Best Probiotics of 2025: Tested and Reviewed

If you’re looking to boost your digestive support or reduce symptoms like bloating by taking a daily probiotic supplement, selecting the right product can make a real difference in how you feel. We worked with a registered dietitian to test and evaluate the best probiotic supplements of 2025.

With gut health impacting your mental state and productivity, prioritizing your digestive health may be just the thing you need to feel better and perform better in the office.

Why Trust Fortune

Our team of expert testers has tried hundreds of the most popular supplements on the market today, using our comprehensive supplement testing methodology to find the best products for all folks.

Best Probiotics of 2025

• Best Probiotic Overall: Ritual Synbiotic+
• Best Probiotic for Constipation: Transparent Labs Gut Health
• Best Probiotic for Gut Health: Onnit Total Gut Health
• Best Budget Probiotic: Nutricost Lactobaccilus Acidophilus
• Best Probiotic for Women: Ora Organic Trust Your Gut
• Best Probiotic for Vaginal Health: O-Positiv Vaginal Probiotic
• Best Probiotic for Men: Biotics8

Best Probiotics Comparison Table

Best Probiotic Overall: Ritual Synbiotic+

Our Thoughts on Ritual Synbiotic+

Ritual’s Synbiotic+ is our pick for the best overall probiotic because of its inclusion of two of the most clinically researched strains: Lactobacillus rhamnosus and Bifidobacterium animalis ssp. lactis, as well as its pre- and post-biotic support. It’s a great 3-in-1 supplement with a hint of mint, making it pleasant to ingest. 

Kate tested this probiotic, rating it a 5 out of 5 for her first impression. “I love Ritual’s packaging: it’s a matte, gray bottle with clean and classy font,” she wrote. “The font is in white on a light gray background, so it could be hard for some people to read.”

Our tester noted that the supplement facts and instructions are clearly labeled and easy to understand. “The bottle is easy to open, and the pills are easy to get out of the bottle. Someone with dexterity issues shouldn’t have too much of a problem opening it,” she said.

Of the pill itself, Kate says, “It’s a typical double encapsulated pill that’s enterically coated. The coating helps protect the second capsule when traveling through the stomach, so that the second capsule can break down in your body.” She rated the ease of taking the capsule as a 3 out of 5.

“The second, inner capsule almost looks like gold flakes that is broken down powder,” Kate explained. “You need one pill per serving.” We like that a single pill gets the job done, rather than having to swallow multiple pills to get the probiotic effects. 

Kate rated the taste and flavor of this supplement as a 3, saying: “It tastes minty. There is also an overwhelming mint smell when you open the bottle, and there’s a mint aftertaste when you take it, as well.” She noted that the mint flavor is pleasant to her, but if you are considering a probiotic and would prefer to avoid any flavors, we recommend Transparent Labs Gut Health.

Our tester rated the side effects of Ritual’s Synbiotic+ as a 3 out of 5, including the aftertaste as a notable side effect from taking this pill. She experienced no discomfort after taking it, but she also noted: “Looking at the reviews, it seems like some people had temporary side effects. After consistent use, it goes away.” So, we recommend being cautious during the first month of adding this supplement to your routine. If you have any concerns, though, it’s always best to consult a medical professional.

Best Probiotic for Constipation: Transparent Labs Gut Health

Our Thoughts on Transparent Labs Gut Health

Transparent Labs Gut Health is our choice as the best probiotic for relieving constipation because it provides a multi-strain, high-CFU probiotic blend that targets regularity and bowel movement comfort. Studies have shown that certain strains of Bifidobacterium (like B. lactis) and Lactobacillus (such as L. casei Shirota) may help improve constipation symptoms by increasing defecation frequency and softening stool. Multi-strain, high-potency products were found to be as helpful as single-strain supplements.

Pete, our resident dietitian, tested this probiotic. He rated it a 5 out of 5 for first impressions: “It’s a small white plastic container that’s travel-friendly. The bottle is easy to open and close, and has a white metallic label with blue lettering.”

He rated the directions a 5, finding them clear and easy to follow. “Take two capsules daily with a full glass of water, preferably on an empty stomach, or as directed by a qualified healthcare professional.”

When taking the capsules, Pete didn’t notice any taste. “They’re clear capsules with white powder, about the length of a quarter and half a centimeter in width,” he wrote. However, he did rate the capsules a 3 out of 5 for swallowability, as they can be a little large for some folks.

Pete didn’t experience any side effects after taking Transparent Labs Gut Health probiotic, giving the supplement a 5 out of 5 in this category. Overall, he noted that this product contains a probiotic blend of 10 strains of probiotic bacteria. “The combined dose is 100 billion CFU, which is considered a strong probiotic supplement,” he said. “Multi-strain probiotics are generally better than single strain options, as they can have a more robust effect on the gut microbiome.”

Best Probiotic for Gut Health: Onnit Total Gut Health

Our Thoughts on Onnit Total Gut Health

Onnit Total Gut Health is our top pick for overall gut health because it combines probiotics, prebiotics, digestive enzymes, and betaine HCl to support gut balance, digestion, and nutrient absorption. It includes five probiotic strains, using a multi-strain approach that has shown success in improving gut health. 

Kayla tested Onnit’s probiotic and had a great first impression, rating it a 5: “I like how it comes in easy-to-take pouches,” she wrote. “The box includes fifteen servings of pre-divided small pouches with seven capsules ready to go.”

Our tester highlighted that the packaging has a lot of information on it, so it may be a little overwhelming, but it does do a good job of explaining the product and its benefits. 

Kayla wasn’t a fan of taking all the pills required for a serving size of this one, rating it only a 1 out of 5 for ease of swallowing the pills. “Seven capsules are a lot of pills to take all at once. I had to break it up in groups of two, and then take the last pill on its own,” she said. “I took the pills with a large meal as suggested by the product instructions.” For those who prefer a smaller dose, we recommend Ritual Synbiotic+. 

Our tester rated the taste of Onnit’s probiotic as a 3 out of 5: “The pills themselves did not have a taste to them, but they did have a slight smell, like gelatin. There was no aftertaste, either,” Kayla said.

Regarding the formulation, Kayla says Onnit is a “robust probiotic supplement that comes at a fairly affordable price point.” Not only does it contain seven strains of probiotics totaling 10 billion CFUs, but it also contains 500 milligrams of betaine hydrochloride, which may help promote stomach acid production, which can aid digestion. 

Best Budget Probiotic: Nutricost Probiotic Complex Capsules

Our Thoughts on Nutricost Probiotic Complex Capsules

We chose Nutricost’s Probiotic Complex Capsules as our pick for the best budget probiotic; they cost less than 50 cents per serving and each bottle includes 60 days’ worth of servings. These probiotics have a fantastic value and include ten different strains of gut-supporting bacteria.

Pete tested Nutricost’s probiotics, rating them a 5 out of 5 for first impression. “The bottle is easy to open and close, and the label is easy to read. It’s a white plastic container with a simple white, blue, and orange label. It would be very travel friendly,” he said. Pete also rated the instructions as a 5, as they’re straightforward and quite easy to follow—take one capsule a day with eight to 12 ounces of water. 

Of the capsules, Pete said, “They’re normal in size, about the length of a quarter and half a centimeter wide.” He rated them a 3 out of 5, noting that they’re easy to swallow. There was no taste to the capsules, he said. He didn’t notice any side effects or digestive issues after testing out Nutricost’s Probiotic Complex, rating it a 5 out of 5 in this category.

If you’re planning to purchase this probiotic, Pete recommends choosing one of the higher potency CFU options available. “Probiotic bacteria that are associated with a healthy gut flora have a combined dosage of greater than 50 billion CFUs,” he said. “This is generally a good sign for probiotics, though high CFU numbers don’t always correlate with the quality of the products. If you’re taking a probiotic to help with gut health, it’s generally recommended to have at least 10 billion CFUs.”

Best Probiotic for Women: Ora Organic Trust Your Gut

Our Thoughts on Ora Organic Trust Your Gut

We chose Ora Organic Trust Your Gut because of the pre- and probiotic support it provides, ideally for women. Women tend to experience constipation more than men, likely due to estrogen slowing muscle contractions in the colon. In particular, the probiotic strain Lactobacillus acidophilus LA-14 has been shown to support vaginal health, too. When that strain is combined along with Bifidobacterium lactis UABla-12, the two together have helped to reduce abdominal pain and symptoms in folks with irritable bowel syndrome (IBS). That said, just about anyone can benefit from this probiotic complex.

Kate tested this probiotic, giving it a 5 out of 5 for first impressions. “The branding of this product is classy and clean. I like the glass bottle, it feels like an expensive product,” she said. She also reported that the labeling is easy to read and understand, and likes that the bottle is transparent enough to know what product is inside. Plus, she considers it easy to open.

Our tester described these probiotics as “clear vegan capsules with a white interior,” noting that they seem like a fairly an average pill size. She rated ease of swallowing a 3 out of 5, saying, “You only need to take two a day. This isn’t an intimidating pill by any means.”

Kate found the directions easy to follow, rating them a 5.

“I didn’t feel any side effects after taking this probiotic,” Kate said. “There was no weird aftertaste, and I didn’t experience any digestive side effects either.” She liked that there was no taste when taking the pills or afterwards. After reading some reviews, Kate did notice some folks experienced temporary side effects, though. If you’re concerned about any potential risks, its best to consult your doctor in advance. 

Overall, Kate says, “This is a good, affordable probiotic for people who are looking for something they can take everyday for digestive support.”

Best Probiotic for Vaginal Health: O-Positiv Vaginal Probiotic

Our Thoughts on O-Positiv Vaginal Probiotic

O-Positiv Vaginal Probiotic is our top pick for vaginal health due to the four strains of probiotics it includes: Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus reuteri, and  Lactobacillus fermentum. These strains, taken alone or combined, may help restore healthy vaginal flora, maintain ideal vaginal pH, and combat odor-causing bacteria. 

Kayla tested O-Positiv’s Vaginal Probiotic, rating it a 5 out of 5 for first impression. “The packaging is a very cute aesthetic with pink branding and trendy fonts,” she says. The container itself is plastic, has a matte finish, and isn’t very large. Kayla thinks it’s good for travel, saying, “It would be easy to throw in your bag.” She notes that the product name is a little misleading, because it could sound like a suppository rather than a pill you take orally. 

Our tester rated this probiotic as a 3 for being easy to swallow, saying, “The pills seem to be standard sized, and even with two pills as the serving size, it’s very manageable.” Kayla noted that the pill is a capsule, and the powder inside is pink in color. “Even the pills themselves seem to go with the girly pink aesthetic,” she says. “I could take the serving size without water if I needed to.” These are a great option for folks who may have difficulty swallowing pills.

Kayla rated the side effects of O-Positiv’s Vaginal Probiotic as a 5, as she experienced no side effects from taking these capsules. Overall, Kayla likes that this product has a 60-day money back guarantee and finds the price point to be solid. 

Another tester on our team, Gwen, has taken O-Positiv for nearly a year. She loves that Amazon allows you to subscribe to monthly deliveries, so it arrives on her doorstep as soon as she finishes a container.

“I have been taking this probiotic consistently for about a year and I definitely think it’s worthwhile,” Gwen writes. “I’m an athlete who spends long periods of time in sweaty gym clothes. You can probably deduce that I experience some personal discomfort, but I have noticed this decrease after consistently taking O-Positiv. As with other probiotics, you probably won’t notice any immediate improvements but over time, I think this can be beneficial. I’m not a doctor, though, so it’s always best to chat with your gynecologist or OB-GYN in advance, especially if you have any reproductive health conditions.”

Best Probiotic for Men: Biotics8

Our Thoughts on Biotics8

Biotics 8 is formulated specifically for men, containing multiple strains of probiotics, prebiotic fibers, Vitamin D, and digestive enzymes. We like the inclusion of both Lactobacillus plantarum and Lactobacillus acidophilus, which help to optimize your gut microbiome, reduce inflammation, and enhance metabolism. The inclusion of Vitamin D may also help to support men’s testosterone production. 

Pete tested Biotics 8, rating it a 5 out of 5 for first impressions. The product comes in a black plastic container with a matte black label and has orange and white lettering. “It’s easy to read, easy to open and close, and is travel friendly,” Pete said.

He found Biotics8 instructions relatively easy to follow, rating them a 3 out of 5 in this category. “For adults, it says to take one capsule per day for the first four days. Then for days five to nine, take two capsules per day. Then, after this you take three capsules per day going forward. The gradual introduction allows time for your gut to adjust,” Pete said. We like this initial ramping up phase, finding it helpful to avoid potential side effects. 

Pete didn’t experience any side effects or digestive issues when taking Biotics8, rating it a 5 out of 5 in this category. Of the experience, he noted that the capsules are “small and clear, with white powder. The capsules are relatively small and easy to swallow. There was no taste or aftertaste to them,” he said.

What Is a Probiotic?

Probiotics are “good” bacteria and yeasts that, when eaten in the right amounts, help keep your gut healthy. They’re found naturally in certain fermented foods—like yogurt, kimchi, and sauerkraut—or can be taken as supplements.

These beneficial microbes help restore balance in your digestive system, crowding out harmful bacteria, while helping support normal body functions. By keeping your gut in check, probiotics may ease digestive discomfort, help your immune system, and support your overall well-being, especially when things like stress, poor diet, or antibiotics disrupt your gut’s natural balance.

Probiotics vs. Prebiotics

How We Tested and Selected the Best Probiotics

We tested and evaluated greens powders and scored them on a scale of 1-5 for factors such as first impressions, swallowability, formula, third-party testing, and price per serving. Our testers evaluate the products based on their own individual experiences and preferences. We then review their testing feedback and data to share our findings and recommendations with you.

Formula

We work with a registered dietitian (RD) during testing to find the most effective and safely formulated probiotic supplements. We look for probiotics that clearly list the specific strain of bacteria on their labeling, since different strains provide different benefits. We also check that the probiotics have at 10 billion colony-forming units (CFUs) per serving.

Swallowability

When testing and selecting probiotics, we also check the ease of swallowing the supplements. Many adults have difficulty swallowing pills, which may lead to skipping doses or quitting your daily supplement routine. A probiotic that’s easier to swallow can mean better consistency, ensuring that you get the full gut-health benefits from the product.

Third-Party Testing

Third-party testing ensures independent verification of safety, purity, as well as nutrition label accuracy. This helps to reduce the risk of mislabeling or underdosing. Third-party testing also checks for harmful substances such as heavy metals, pesticides, and more for safety. 

The FDA (U.S. Food and Drug Administration) does not regulate supplements, so it’s vital to have independent testing done to ensure safety, accuracy, and quality.

Value

When considering value, we place a premium on brands that source their ingredients in America and have certifications, such as Informed Choice.

How to Find the Best Probiotics for You

Everyone has different reasons for taking a probiotic, depending on your goals, dietary needs, allergies, and any health conditions you manage.  

Here’s what to consider when selecting the best probiotic supplement for you.

Your Body’s Needs

Not all probiotics work the same way; their effects are strain-specific. Your body type, immune system, digestive environment, genetics, and sex can all help determine your response to a particular probiotic strain. To optimize your benefits, choose a probiotic based on the health condition you are managing, along with any dietary needs or goals.

That said, if you’re experiencing symptoms that affect your day-to-day tasks, we recommend speaking with a healthcare professional before trying any new supplements.

Common Symptoms

• Abdominal pain and bloating: Lactobacillus plantarum 299v, Bacillus coagulans LBSC
• Diarrhea: Saccharomyces boulardii, Bifidobacterium animalis subsp. lactis BB-12 
• Constipation: Lactobacillus acidophilus, Bifidobacterium bifidum

Formula

We recommend talking with your doctor about the best probiotic for your body. Since probiotics can vary by strains included, your doctor or gastroenterologist can help with suggestions on the best kind for your dietary needs, health goals, and conditions you are managing.

Cost

Supplements can be expensive, so it’s important to think about your budget when considering adding a new supplement to your daily routine. Some probiotics require you to take multiple capsules per day, which means you may need to buy the probiotics more frequently than once every few months. 

Third-Party Testing

Third-party testing independently verifies the safety, purity, and label accuracy of probiotics since the FDA doesn’t regulate supplements. This process helps protect you from mislabeling, contamination, and banned substances, building trust and ensuring you can use products with confidence. Independent testing is essential for confirming product quality and safeguarding your health.

Benefits of Probiotics

Taking probiotics can help keep your digestive system balanced, boost immunity, and may even have effects that reach beyond your gut. Here are some of the benefits:

• Improved gut health: Probiotics can help balance your gut microbiome, supporting regular digestion and easing issues such as bloating, constipation, and diarrhea.
• Lower risk of GI diseases: Regular use of probiotics may lower the risk or severity of gastrointestinal problems, such as IBS
• Immune support: Some probiotic strains can help strengthen the immune system by supporting a healthy gut barrier
• Cardiovascular and metabolic health: Some probiotics have been linked to lower cholesterol levels and better regulation of blood sugar, though they don’t create a direct cause and effect 

When to Take Probiotics

There’s no best time of day to take probiotics—what matters most is taking them regularly at a time you’ll remember. 

We suggest checking the label of the supplement you choose to see if there are directions for when the probiotic is best taken. If not, we recommend taking your probiotic along with your breakfast each day.

What to Avoid

When selecting a probiotic, there are some aspects to avoid:

• Artificial sweeteners, fillers, or other additives, as these can cause stomach upset or possible allergies
• Products that don’t clearly list the specific strains or count
• Products that don’t include directions on storage—refrigeration is often needed
• Products that don’t guarantee live bacteria by the expiration date

Frequently asked questions

What is the most effective probiotic on the market?

Our team selected Ritual’s Synbiotic+ as our pick for the best overall probiotic because of its inclusion of two of the most clinically validated strains: Lactobacillus rhamnosus and Bifidobacterium animalis ssp. lactis, as well as its pre- and post-biotic support. It’s a great 3-in-1 supplement with a hint of mint, making it pleasant to ingest.

What are signs you need a probiotic?

Signs that you might benefit from using a probiotic include:

• Frequent digestive issues such as bloating, diarrhea, or constipation
• If you’ve recently taken antibiotics or are experiencing diarrhea because of taking antibiotics 
• If you’ve had repeated infections or feel your immunity could be stronger

If you’re experiencing these symptoms or thinking about starting a probiotic regimen, we recommend speaking with your doctor.

Is there a downside to taking probiotics?

While most people tolerate probiotics well, some potential downsides may include bloating, gas, or stomach discomfort within the first few weeks of starting a probiotic.

Is it better to take probiotics in the morning or night?

There isn’t a best time to take probiotics, necessarily. Experts have said that it’s best to take probiotics consistently, every day, rather than at a certain time.