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NewslettersMPW Daily

What to know about Anthropic cofounder Daniela Amodei as the OpenAI competitor races toward profitability

Emma Hinchliffe
By
Emma Hinchliffe
Emma Hinchliffe
Most Powerful Women Editor
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Emma Hinchliffe
By
Emma Hinchliffe
Emma Hinchliffe
Most Powerful Women Editor
Down Arrow Button Icon
December 2, 2025, 10:32 AM ET
Dario Amodei (L) and Daniela Amodei (R) co-founders, CEO and president of Anthropic photographed at their SF headquarters on November 5th 2025.
Dario Amodei (L) and Daniela Amodei (R) co-founders, CEO and president of Anthropic photographed at their SF headquarters on November 5th 2025.Jessica Chou for Fortune

On the latest cover of Fortune are a brother and sister: Dario and Daniela Amodei, the cofounders of Anthropic. The OpenAI competitor is now projected to bring in $10 billion in 2025 revenue, with a $183 billion valuation. Notably, its path to profit looks shorter than those of its rivals—with profitability expected in 2028.

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My colleague Jeremy Kahn, Fortune‘s AI editor and author of the book Mastering AI, dives into Anthropic’s business and future in this cover story.

His story also gives us some insight into Daniela herself. As cofounder of Anthropic, she’s one of the most consequential female founders in tech today. Her title is president; she focuses on day-to-day operations and the commercial side of the business, while Dario sets vision, strategy, research and policy.

While Anthropic’s focus on AI safety has been a key distinguisher of its chatbot Claude from its competitors, Daniela’s work commercializing the business is turning out to be a standout factor too. Consumer businesses are in the game of monetizing attention, Dario explains—and the incentives don’t always align to prioritize safety (hence the rise of “AI slop”). Enterprise customers often see safety as a selling point, avoiding problematic outputs like “giving someone instructions for making a bioweapon, revealing company secrets, or spewing hate speech,” Jeremy writes.

Daniela seems to be a cautious leader. “I have probably been the leader who’s been the most skeptical and scared of the rate at which we’re growing,” she told Jeremy. But she says she’s been “continually, pleasantly surprised” that the company hasn’t come apart at the seams, culturally or operationally.

I highly recommend reading Jeremy’s full cover story here.

Emma Hinchliffe
emma.hinchliffe@fortune.com

The Most Powerful Women Daily newsletter is Fortune’s daily briefing for and about the women leading the business world. Subscribe here.

ALSO IN THE HEADLINES

Where Canva's going next. The Sydney-based visual communications company is now valued at $42 billion, the highest valuation for a woman-led and -founded startup in the world. Melanie Perkins and her cofounders chat about the path ahead, including a possible IPO and AI workflows. Inc. 

Moms First is setting a record. Reshma Saujani's advocacy organization is producing a new documentary about American motherhood. She tells me it's the "first film that traces the history of American motherhood, from postwar propaganda to the forces that divide us and the cultures that keep us from building solutions." They're gathering thousands of moms to sign on as associate producers—aiming to break a Guinness World Record. 

Disney's succession race is in the home stretch. Dana Walden, TV head, and parks chief Josh D’Amaro are the two final contenders. The board has said it expects to make a decision in early 2026. WSJ

Gretchen Whitmer is Trump's favorite Democrat. The Michigan governor has worked with the president (including a mini scandal when she hid her face in a photo). As Democrats figure out who will lead the party going into the 2028 election, Whitmer and Trump have a "surprisingly productive and affable relationship"—helpful for getting things done, but not always popular with Democratic voters. Politico

ON MY RADAR

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PARTING WORDS

"Live a truthful life, then you don't have any."

— Melinda French Gates on secrets. She's interviewed on the latest episode of Wired's "The Big Interview" podcast. 

This is the web version of MPW Daily, a daily newsletter for and about the world’s most powerful women. Sign up to get it delivered free to your inbox.
About the Author
Emma Hinchliffe
By Emma HinchliffeMost Powerful Women Editor
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Emma Hinchliffe is Fortune’s Most Powerful Women editor, overseeing editorial for the longstanding franchise. As a senior writer at Fortune, Emma has covered women in business and gender-lens news across business, politics, and culture. She is the lead author of the Most Powerful Women Daily newsletter (formerly the Broadsheet), Fortune’s daily missive for and about the women leading the business world.

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