• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia
NewslettersTerm Sheet

Term Sheet Next: How a16z crypto’s Arianna Simpson has navigated the blockchain rollercoaster

Leo Schwartz
By
Leo Schwartz
Leo Schwartz
Senior Writer
Down Arrow Button Icon
September 8, 2025, 7:02 AM ET
Arianna Simpson, general partner at Andreessen Horowitz.
Arianna Simpson, general partner at Andreessen Horowitz.Nathan Laine—Getty Images

When Arianna Simpson was 22 years old, she plowed her savings into Bitcoin. She had left her college job and traveled with a friend through Zimbabwe, witnessing firsthand the consequences of hyperinflation. When she returned, she became enamored with the idea of crypto as a potential salve. 

Recommended Video

Aside from investing the contents of her bank account, Simpson started a blockchain lunch meetup at her next post, Facebook. She wrote a blog post on multisignature wallets that landed her a job at the infrastructure startup BitGo, where she became the third employee. (More than 10 years later, BitGo is set to go public, though Simpson sadly left before her shares vested.) 

Instead of sticking it out in the early crypto startup trenches, Simpson moved into venture, first working at a friend’s generalist firm before starting her own crypto fund, Autonomous Partners, which raised from Brian Armstrong, David Sacks’ Craft Ventures, and Steve Cohen’s family office. This was 2017, when crypto was beginning to explode into the mainstream, and Simpson invested in companies like Talos and Mythical Games. Through Armstrong, she also met Katie Haun, a Department of Justice prosecutor-turned-a16z investor, who convinced Simpson to come on board. 

Simpson joined a16z crypto as a deal partner in 2020. She liked that the firm had stayed in blockchain during the quiet times, which isn’t the case for many of the larger venture operations (even today, blue-chip names like Accel and Bessemer have mostly stayed away since the 2022 collapse). “I had a lot of respect and appreciation for the fact that the firm, despite being like an institution, had taken this category seriously,” Simpson says. 

It turned out to be a prudent decision. Simpson came on right at the start of the boom years, which included a16z crypto’s landmark $2.2 billion third fund in 2021 and $4.5 billion fourth fund in 2022. And amid power players like Chris Dixon and Haun, she made a name for herself investing early in companies like Blackbird, the dining rewards startup created by Resy cofounder Ben Leventhal, and Phantom, the crypto wallet recently valued at $3 billion. 

Now a general partner, Simpson’s approach has been to target founders, rather than just thematic areas, understanding that the best builders will be drawn to the most promising technology at the moment, whether it’s stablecoins or the intersection of crypto and AI. “It’s more about following the trends of entrepreneurs than it is unilaterally trying to decide what’s interesting,” she says. “As an investor, your job is to shift your attention to find it.”

See you tomorrow,

Leo Schwartz
X:
@leomschwartz
Email: leo.schwartz@fortune.com

Submit a deal for the Term Sheet newsletter here.

Joey Abrams curated the deals section of today’s newsletter. Subscribe here.

VENTURE DEALS

- Shift5, a Rosslyn, Va.-based operational intelligence company designed for defense and transportation systems, raised $75 million in Series C funding. Hedosophia led the round and was joined by Insight Partners, Center 15 Capital, 645 Ventures, Moore Strategic Ventures, Booz Allen Ventures, and others.

- Euclid Power, a New York City-based operating system for renewable energy project operations, raised $20 million in Series A funding. Venrock led the round and was joined by HSBC Asset Management, Spero Ventures, Toba Capital, Designer Fund, and Commonweal Ventures.

- Isotopes.AI, a Palo Alto, Calif.-based agentic AI company, raised $20 million in seed funding from NTTVC.

- Tobe Energy, a Oklahoma City, Okla.-based green hydrogen company, raised $1.8 million in seed funding. Cortado Ventures led the round and was joined by 46 VC, Techstars, and others.

PRIVATE EQUITY

- UltraViolet Cyber, backed by Achieve Partners, acquired the Application Security Testing business of Black Duck Services, a Burlington, Mass.-based application security platform. Financial terms were not disclosed.

EXITS

- Vision agreed to acquire Marcolin, a Longarone, Italy-based eyewear company, from PAI Partners. Financial terms were not disclosed.

FUNDS + FUNDS OF FUNDS

- Platinum Equity, a Los Angeles, Calif.-based private equity fund, raised $2.28 billion for its second small cap fund focused on the lower middle market companies.

PEOPLE

- Invidia Capital Management, a New York City-based private equity firm, hired Shaunak Parikh as a partner. He was formerly with EW Healthcare Partners.

This is the web version of Term Sheet, a daily newsletter on the biggest deals and dealmakers in venture capital and private equity. Sign up for free.
About the Author
Leo Schwartz
By Leo SchwartzSenior Writer
LinkedIn iconTwitter icon

Leo Schwartz is a senior writer at Fortune covering fintech, crypto, venture capital, and financial regulation.

See full bioRight Arrow Button Icon

Latest in Newsletters

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025

Most Popular

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • Future 50
  • World’s Most Admired Companies
  • See All Rankings
Sections
  • Finance
  • Leadership
  • Success
  • Tech
  • Asia
  • Europe
  • Environment
  • Fortune Crypto
  • Health
  • Retail
  • Lifestyle
  • Politics
  • Newsletters
  • Magazine
  • Features
  • Commentary
  • Mpw
  • CEO Initiative
  • Conferences
  • Personal Finance
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
About Us
  • About Us
  • Editorial Calendar
  • Press Center
  • Work At Fortune
  • Diversity And Inclusion
  • Terms And Conditions
  • Site Map

Latest in Newsletters

AIEye on AI
Silicon Valley’s tone-deaf take on the AI backlash will matter in 2026
By Sharon GoldmanDecember 23, 2025
9 hours ago
NewslettersMPW Daily
Why women’s rise to the top of business is stalling
By Emma HinchliffeDecember 23, 2025
11 hours ago
Merchants use artificial intelligence technology to connect to modern financial technology banking systems.
NewslettersCFO Daily
AI is reshaping banking—but not causing a jobs wipeout
By Sheryl EstradaDecember 23, 2025
15 hours ago
NewslettersTerm Sheet
As AI investors fret over ROI, these startups attracted serious cash from customers in 2025
By Allie GarfinkleDecember 23, 2025
17 hours ago
Sheldon Kimber, CEO of Intersect Power, right, at the Oberon Solar plant near Desert Center, California, on Oct. 25, 2023. (Photo: Lauren Justice/Bloomberg/Getty Images)
NewslettersFortune Tech
Why Alphabet will acquire Intersect Power
By Andrew NuscaDecember 23, 2025
17 hours ago
NewslettersCEO Daily
AptarGroup CEO: China is unfazed by Trump’s tariffs because their ‘grit and sheer willpower is on a different scale’
By Diane BradyDecember 23, 2025
17 hours ago

Most Popular

placeholder alt text
Success
Billionaire philanthropy's growing divide: Mark Zuckerberg stops funding immigration reform as MacKenzie Scott doubles down on DEI
By Ashley LutzDecember 22, 2025
1 day ago
placeholder alt text
Success
Former U.S. Secret Service agent says bringing your authentic self to work stifles teamwork: 'You don’t get high performers, you get sloppiness'
By Sydney LakeDecember 22, 2025
1 day ago
placeholder alt text
Travel & Leisure
After pouring $450 million into Florida real estate, Larry Ellison plans to lure the ultrarich to an exclusive town just minutes from Mar-a-Lago
By Marco Quiroz-GutierrezDecember 22, 2025
2 days ago
placeholder alt text
Success
The average worker would need to save for 52 years to claw their way out of the middle class and be classified as wealthy, new research reveals
By Orianna Rosa RoyleDecember 23, 2025
11 hours ago
placeholder alt text
Success
'When we got out of college, we had a job waiting for us': 80-year-old boomer says her generation left behind a different economy for her grandkids
By Mike Schneider and The Associated PressDecember 23, 2025
14 hours ago
placeholder alt text
Success
OpenAI's CEO Sam Altman says in 10 years' time college graduates will be working 'some completely new, exciting, super well-paid' job in space
By Preston ForeDecember 23, 2025
13 hours ago

© 2025 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.