• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia

Trendingnow

1

Social Security unraveling: 7,100 workers sacked, performance metrics retired, disability claims falling

2

Erin Brockovich, the activist who defeated a utility giant and inspired a Julia Roberts film, is pushing data centers to be more transparent

3

'Where we are today is frightening': a Pulitzer-winning historian sees a doomsday scenario involving China and the national debt

1

Social Security unraveling: 7,100 workers sacked, performance metrics retired, disability claims falling

2

Erin Brockovich, the activist who defeated a utility giant and inspired a Julia Roberts film, is pushing data centers to be more transparent

3

'Where we are today is frightening': a Pulitzer-winning historian sees a doomsday scenario involving China and the national debt
Health

These Were the 10 Biggest Pharmaceutical Deals of 2016

By
Sy Mukherjee
Sy Mukherjee
Down Arrow Button Icon
By
Sy Mukherjee
Sy Mukherjee
Down Arrow Button Icon
February 24, 2017, 7:00 AM ET
157292981
Paying cashPhotograph by Guillermo Perales Gonzalez — Getty Images

Last year was, well, not the greatest for the drug industry.

A contentious presidential election where both candidates slammed the biopharma industry, with a healthy assist from a cast of cartoonish, price-gouging villains, marred the entire sector (the NASDAQ Biotech Index fell some 20% over the course of the year). And that also had an effect on dealmaking, with a dearth of health care “megadeals” and a retrenchment in overall deal value, according to a new analysis by analytics firm Evaluate’s EP Vantage arm.

Click here to subscribe to Brainstorm Health Daily, our brand new newsletter about health innovations.

The largest biopharma deals announced in 2016 (not all of them have closed quite yet) contained just one M&A topping the $30 billion threshold: rare disease specialist Shire’s acquisition of Baxter spinoff Baxalta. The other big notable was Pfizer’s buyout of the heavily-sought cancer drug maker Medivation, which had been pursued by a number of other biopharma giants like Merck, Gilead, and Sanofi.

(Sanofi has had a particularly frustrating 12 months in dealmaking – the firm also lost out on the European biotech Actelion to Johnson & Johnson this year, a deal valued at $30 billion.)

10-biggest-deals
EP Vantage

Overall deal value for the year dropped, too, with the average for deals falling to $659.6 million. But, to be fair, the figures are a bit skewed thanks to a monster 2014 of biopharma deal-making.

average-ma-deals
EP Vantage
EP Vantage

The report authors did cite one concerning trend: a relative lack of risk-taking in the M&As which were announced last year.

“Six of the top 10 acquisitions were of companies with established products; a seventh was of Celator, a company that had already passed a phase III milestone; and an eighth, Anacor, had already submitted Eucrisa to the FDA when Pfizer made its play,” the wrote. “That leaves only Abbvie’s acquisition of Stemcentrx and Allergan’s of Tobira as truly risky transactions. A look at average deal values, sliced a couple of ways, also shows a pullback in 2016. This could well be a result of the general avoidance of more risky moves, as well as lower valuations overall.”

The question going forward is how willing the sector will be to striking deals amid mixed messages from the Trump administration. On the one hand, President Trump has vowed to deregulate the FDA to speed drug approvals (a gift that some major biopharma executives don’t really want in the first place over concerns that it would cause insurers to ditch their products). On the other, he’s slammed pharma industry price hikes and endorsed policies like direct Medicare negotiations over treatment prices.

If stock prices are any indication, this year could wind up being slightly better for biopharma M&A. Major biotech indices are up nearly 9% year-to-date.

About the Author
By Sy Mukherjee
See full bioRight Arrow Button Icon

Latest in Health

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025

Most Popular

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Fortune Secondary Logo
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • World's Most Admired Companies
  • See All Rankings
  • Lists Calendar
Sections
  • Finance
  • Fortune Crypto
  • Features
  • Leadership
  • Health
  • Commentary
  • Success
  • Retail
  • Mpw
  • Tech
  • Lifestyle
  • CEO Initiative
  • Asia
  • Politics
  • Conferences
  • Europe
  • Newsletters
  • Personal Finance
  • Environment
  • Magazine
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
  • Group Subscriptions
About Us
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • Facebook icon
  • Twitter icon
  • LinkedIn icon
  • Instagram icon
  • Pinterest icon

Latest in Health

pox
North AmericaScience
Two government virologists smuggled Mpox vials into the U.S. It’s not clear why
By Ed White and The Associated PressJune 3, 2026
3 hours ago
The 4 Best Hair Loss Treatments for Women in 2026: Tested for Results and Regrowth
HealthDietary Supplements
The 4 Best Hair Loss Treatments for Women in 2026: Tested for Results and Regrowth
By Christina SnyderJune 3, 2026
3 hours ago
The 4 Best Scalp Massagers for Hair Growth: Tested and Reviewed
HealthDietary Supplements
The 4 Best Scalp Massagers for Hair Growth: Tested and Reviewed
By Emily PharesJune 3, 2026
3 hours ago
dr. oz
HealthWhite House
Dr. Oz on why Trump appointed a real-estate heir as acting intelligence chief: ‘I think Bill’s a great guy. I know him socially’
By Will Weissert, Josh Boak and The Associated PressJune 3, 2026
7 hours ago
Create Creatine Gummies Review (2026): Tasted and Tested by Experts
HealthDietary Supplements
Create Creatine Gummies Review (2026): Tasted and Tested by Experts
By Christina SnyderJune 2, 2026
1 day ago
Transparent Labs Probiotics Review (2026): RD Reviewed
HealthDietary Supplements
Transparent Labs Probiotics Review (2026): RD Reviewed
By Emily PharesJune 2, 2026
1 day ago

Most Popular

Social Security unraveling: 7,100 workers sacked, performance metrics retired, disability claims falling
North America
Social Security unraveling: 7,100 workers sacked, performance metrics retired, disability claims falling
By Katie Savin, Callie Freitag, Matthew Borus and The ConversationJune 2, 2026
1 day ago
Erin Brockovich, the activist who defeated a utility giant and inspired a Julia Roberts film, is pushing data centers to be more transparent
Environment
Erin Brockovich, the activist who defeated a utility giant and inspired a Julia Roberts film, is pushing data centers to be more transparent
By Marco Quiroz-GutierrezJune 1, 2026
2 days ago
'Where we are today is frightening': a Pulitzer-winning historian sees a doomsday scenario involving China and the national debt
Banking
'Where we are today is frightening': a Pulitzer-winning historian sees a doomsday scenario involving China and the national debt
By Nick LichtenbergJune 2, 2026
2 days ago
Cognizant CEO says AI is remaking middle managers into player-coaches who can 'both  execute and develop others'
Newsletters
Cognizant CEO says AI is remaking middle managers into player-coaches who can 'both execute and develop others'
By Diane BradyJune 2, 2026
2 days ago
Current price of oil as of June 2, 2026
Personal Finance
Current price of oil as of June 2, 2026
By Joseph HostetlerJune 2, 2026
1 day ago
Current price of gold as of June 2, 2026
Personal Finance
Current price of gold as of June 2, 2026
By Danny BakstJune 2, 2026
1 day ago

© 2026 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.