Bernadette Ruth Irawati Setiady

Bernadette Ruth Irawati Setiady, niece of late founder Boenjamin Setiawan, first led Kalbe Farma from 2008 to 2017, then returned as president director of Southeast Asia's largest listed drugmaker in 2024. She is pushing the Jakarta firm into biologics and cell therapy, and opened Indonesia's first private radioisotope plant—radioactive drugs that diagnose and treat cancer. Margins are under pressure—a weak rupiah and costlier imported ingredients cut first-half net profit 2.8%—but revenue grew 14% to 19.5 trillion rupiah ($1.1 billion)