The Best Nitric Oxide Supplements of 2025: Approved by Medical Experts

Our team of expert testers has tried a variety of supplements, ranging from multivitamins to creatine powders—needless to say, we know supplements. We worked with a certified nutrition coach to trial and select the best nitric oxide supplements of 2025.

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Our team of expert testers has tried hundreds of the most popular supplements on the market today, using our comprehensive supplement testing methodology to find the best products for all folks.

Best Nitric Oxide Supplements of 2025

• Best Nitric Oxide Supplement Overall: Transparent Labs Nitric Oxide
• Best Nitric Oxide Supplement for Muscle Growth: SNAP Supplements Nitric Oxide Organic Beets
• Best Budget Nitric Oxide Supplement: Nutricost Nitric Oxide
• Best Organic Nitric Oxide Supplement: KOS Beet Root Powder
• Best Vegan Nitric Oxide Supplement: DoubleWood Nitric Oxide

Best Nitric Oxide Supplements Comparison Table

Best Nitric Oxide Supplement Overall: Transparent Labs Nitric Oxide

Our Thoughts on Transparent Labs Nitric Oxide

Transparent Labs Nitric Oxide is our pick for the best nitric oxide supplement overall because of its unique dual-pathway formula, clinical ingredient transparency, and stimulant-free design. Featuring patented NO3-T® arginine nitrate and betaine nitrate, the supplement supports nitric oxide production by maximizing blood flow, muscle pumps, and supporting cardiovascular health.

Pete tested this supplement, rating his first impression of the product a 5 out of 5. “The capsules come in a white plastic container with a screw top lid that opens and closes easily. The label is white and features blue and black text that’s easy to read. It’s travel-friendly,” he said. He found the instructions easy to read and follow, also rating them a 5 out of 5. “It says to take four capsules 30 to 45 minutes before a workout on an empty stomach.”

He rated the swallowability as 3 out of 5. This has the highest number of capsules per serving on our list: the product instructions say to take four capsules on days that you exercise. Pete found the capsules to be tasteless and odorless, luckily, and he didn’t experience any side effects or digestive issues after taking the supplement. So, aside from the pill total, they’re definitely manageable.

“During testing, I didn’t experience anything dramatic in terms of muscle pump, but I also do CrossFit and not bodybuilding, where pumps are more noticeable,” Pete said. “When I took the product, though, I did feel like I had good energy throughout my workout.”

Best Nitric Oxide Supplement for Muscle Growth: SNAP Supplements Nitric Oxide Organic Beets

Our Thoughts on Snap Supplements Nitric Oxide Organic Beets

Snap Supplements Nitric Oxide Organic Beets is our pick for the best nitric oxide supplement for muscle growth because it uses organic, high-potency ingredients that directly support enhanced blood flow and muscle endurance, without adding unnecessary fillers or artificial ingredients. The blend of beetroot, L-citrulline, and L-arginine reflects current research to maximize nitric oxide production.

Pete tested this supplement, rating his first impression of the product a 5 out of 5. “The powder comes in a small white plastic container with a screw top lid that opens and closes easily,” he said. “The white label features dark red and black text that’s easy to read, and the metallic accents on some of the text and graphics add a nice visual pop to the label. A scoop is included for quick and accurate measuring.”

Whereas many other nitric oxide supplements come in capsule form, this one is a mixable powder. After preparing the product in his shaker cup, Pete rated the mixability as a 5 out of 5 as well. The powder dissolved fully in sixty seconds, and no further shaking was required. 

After a few sips, Pete loved the taste of this product. “You can taste the natural beet flavor, and it’s balanced nicely with the sweetness from the stevia leaf extract,” he said. He found it refreshing and tasty without the overly earthy notes he’s experienced with other beet root powders. “The mouthfeel is also quite smooth. There was only a slight bit of grit towards the bottom of the shaker bottle, making it an enjoyable drink.”

Pete thinks that beet root powders are a viable alternative to pre-workout supplements, especially for folks who don’t want a caffeinated product or who work out in the evenings and don’t want to disrupt their sleep.

Best Budget Nitric Oxide Supplement: Nutricost Nitric Oxide

Our Thoughts on Nutricost Nitric Oxide

Nutricost Nitric Oxide is our pick for the best budget nitric oxide supplement, combining cost-effectiveness with a strong, evidence-backed formula of arginine and citrulline to amplify blood flow, enhance workout endurance, and support recovery. We love that each bottle will last 30 days, and each serving cost breaks down to only 40 cents.

Pete tested this supplement, rating his first impression of the product a 5 out of 5. “It comes in a medium-sized white plastic bottle with a black screw top lid that opens and closes smoothly. The label is simple and the text is easy to read,” he said. He liked that the front of the label clearly lists the key ingredients, so you know exactly what you’re getting. It’s a little too large of a container to be travel-friendly, though it can probably fit in a larger gym bag.

He rated swallowability a 3 out of 5: “This supplement comes as clear capsules filled with a fine white powder. The capsules are slightly larger than average, just over an inch in length and a centimeter wide. Each serving is three capsules per day,” he said. Pete noted that the capsules are both tasteless and odorless, though. If you’re someone who prefers a powder supplement, we recommend SNAP Supplements Nitric Oxide Organic Beets.

Overall, Pete thinks this formulation provides some nitric oxide precursor support, but the dosages of arginine and citrulline are a bit lower than the amounts shown by clinical research to boost nitric oxide. That said, he did give the side effects a 5 out of 5, as he didn’t experience any unwanted aftertaste or digestive issues.

Best Organic Nitric Oxide Supplement: KOS Beet Root Powder

Our Thoughts on KOS Beet Root Powder

KOS Beet Root Powder is our pick for the best organic nitric oxide supplement for its purity, organic certification, and effectiveness in boosting natural nitric oxide through high nitrate content from whole beets. It’s an excellent option for those prioritizing clean, non-GMO, and plant-based nutrition.

Pete tested this supplement, rating his first impression of the product a 5 out of 5. “This supplement comes in a sturdy white plastic tub with a screw top lid that opens and closes easily,” he said. He liked the label’s fun design, which features cartoon-style beets weightlifting, surfing, boxing, dancing, and more. As this one is a powder, it also comes with a scoop for easy measuring.

After preparing the drink, Pete was impressed with the solubility. He rated the mixability of KOS Beet Root Powder as a 5 out of 5, as the product fully dissolved in 60 seconds: “The texture was super smooth, there wasn’t any clumping of powder or gritty texture,” he said.

Before his workout, this tester gave the drink a try, rating the taste a 3 out of 5. “The only ingredient in this product is organic beetroot powder, which is great for folks who are looking for an all-natural, single ingredient formula. This means there’s no added flavor or sweetness: if you haven’t tried beetroot before, it has an earthy taste with a slight hint of natural sweetness.” That said, you can easily mix this formula with a flavored supplement, like BCAAs, or a little fruit juice to improve the taste. 

Overall, our tester was pleased by this supplement’s simple and clean formula. “People would take this supplement primarily for its nitrate content, which is a precursor to nitric oxide in the body. It has potential as a natural and stimulant free alternative to traditional pre-workouts. Though the overall effects are far more modest,” Pete said.

Best Vegan Nitric Oxide Supplement: DoubleWood Nitric Oxide

Our Thoughts on DoubleWood Nitric Oxide

DoubleWood Nitric Oxide is our pick for the best vegan nitric oxide supplement because of its innovative use of patented Nitrosigine and a stack of proven amino acid forms in a pure, vegan-friendly formula. The focus on clean ingredients, US-based manufacturing, and third-party quality standards gives plant-based athletes and gym goers a reliable way to support workouts, pumps, and circulatory health.

Pete tested this supplement, rating his first impression of the product as a 5 out of 5. “This supplement comes in a white plastic bottle with a screw top lid that opens and closes easily. The label is accented with bright colored text which stands out against the label and is easy to read,” he said. The bottle is slightly too large to be travel-friendly, per Pete, but you could easily grab a handful of the capsules and travel with them in a plastic bag or pill container.

He rated swallowability as 3 out of 5: “The size of the capsules are slightly smaller than average, about three quarters of an inch in length and half a centimeter in width. The recommended serving size is three capsules per day.” Pete found the capsules to be tasteless and odorless.

Of the formulation, Pete notes that “The inclusion of Nitrosigine is a plus since there are clinical studies that have shown improvements in blood flow and nitrate levels, suggesting real NO-boosting potential. However, the studies do use 1,500 milligrams of Nitrosigine while this supplement only has 500 milligrams.” Overall, he thinks this supplement offers some NO support, but the overall amino acid dosages could be higher.

What is Nitric Oxide? 

Nitric oxide is a naturally occurring molecule in the body that plays a crucial role in several biological functions, particularly by helping blood vessels relax and widen. Nitric oxide supplements typically contain ingredients like L-arginine, L-citrulline, or dietary nitrates, which are precursors that help the body produce more nitric oxide. 

People take these supplements for their potential to promote cardiovascular health, lower blood pressure, improve blood flow, and enhance exercise performance and recovery by increasing oxygen delivery and nutrient uptake into muscles during workouts. Nitric oxide is also believed to aid in quicker recovery, reduced muscle soreness, and even better endurance, making it a popular option among athletes and fitness enthusiasts of all levels.

How We Tested and Selected the Best Nitric Oxide Supplements

Our review process is designed to identify the most effective nitric oxide supplements for a range of user needs. We evaluated dozens of products for their ingredient formulas, taste, third-party testing, and overall value to ensure that only the best in each category were selected.

Formula

We prioritized products containing well-studied nitric oxide-boosting ingredients such as L-arginine, L-citrulline, beetroot extract, and patented ingredients like Nitrosigine. These components are chosen for their proven ability to raise nitric oxide levels and deliver intended performance and wellness benefits.

Third-Party Testing

We place significant emphasis on third-party testing, as supplements are not regulated by the FDA as strictly as other foods or pharmaceuticals. Third-party testing means that an independent organization has verified the product’s ingredients and purity, giving you added confidence that what’s on the label is what’s in the bottle and that it is free from unwanted contaminants. 

Value

When determining the best-value nitric oxide supplement, we weigh factors such as ingredient quality, clinical dosing, serving count, and price per serving against one another.

How to Find the Best Nitric Oxide Supplement for You

Choosing the right nitric oxide supplement can make a difference in your performance and health routine. With a wide variety of options available, considering your personal needs, preferences, and lifestyle can help ensure you select a supplement that fits seamlessly into your daily routine.

Your Fitness Goals

Different individuals have diverse fitness aspirations, whether it’s increased endurance, muscle pump, or recovery support. Defining your primary goals—such as boosting athletic performance, supporting cardiovascular health, or simply increasing energy levels—can help narrow your search down to a product that specifically addresses your unique needs.

Flavors

Taste is a major factor, especially if you’ll be sipping your supplement daily. Finding a flavor you genuinely enjoy can make it much easier to maintain consistency. Many nitric oxide supplements come in a variety of flavors, while some are offered in convenient, flavorless capsules for those who prefer a simple approach.

Formula

Everyone’s nutritional requirements are different. It’s wise to review each supplement’s ingredient list for allergens, artificial additives, and overall macronutrient content. Most formulas can be stacked with other supplements such as NMN or NAD, but it’s wise to check with your doctor about combining supplements before starting.

Cost

Supplements can vary significantly in price. While products with cleaner, science-backed formulas may have a higher upfront cost, investing in quality often pays off, especially for something you’ll be consuming daily. Set a budget, compare options, and remember that your health is worth the extra investment if the product meets your standards.

Third-Party Testing

Look for supplements that are third-party tested to ensure safety, potency, and purity. Third-party evaluations offer peace of mind that the ingredients on the label match what’s inside the bottle, with no hidden contaminants or banned substances. 

Benefits of Nitric Oxide Supplements

Nitric oxide boosters aren’t just for professional athletes; they can offer a range of science-supported benefits for a wide audience. Here are a few benefits:

• Improved blood flow and circulation
• Enhanced workout performance and muscle pumps
• Reduced exercise fatigue and faster recovery
• Support for healthy blood pressure levels

How to Take Nitric Oxide

Most nitric oxide supplements are best taken mixed with liquid, such as water or juice. If you prefer variety, you can get creative by blending the powder into smoothies, yogurt, or pre-workout snacks. If you opt for capsule formulations, simply follow the package directions for dosage. If using a powder, you can also mix in with your favorite greens powder or another powder supplement.

What to Avoid in Nitric Oxide

Not all nitric oxide supplements are created equally. Watch out for, and avoid:

• Unproven proprietary blends lacking ingredient transparency
• Excessive artificial sweeteners, colors, and unnecessary additives
• Stimulants or other additions not aligned with your health or sensitivities

Frequently asked questions

What is the best form of nitric oxide to take?

Supplements featuring clinically supported forms like l-citrulline, arginine nitrate, or NO3-T® nitrates tend to deliver the best results for most users.

What is the best nitric oxide supplement?

Transparent Labs Nitric Oxide is our pick of the best overall nitric oxide supplement because of its dual-pathway approach, quality ingredients, and third-party testing.

What are the negative side effects of taking nitric oxide?

Some users experience mild side effects like stomach upset or headaches. Rarely, excessive use of certain nitric oxide boosters can cause changes in blood pressure or interact with medications, so we recommend that you talk with your doctor or other healthcare professional before starting a new supplement.