• Home
  • News
  • Fortune 500
  • Tech
  • Finance
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia
TechStartups & Venture

This startup believes shopping around for prescription drugs should be as easy as shopping on Amazon. The future of a $700 billion industry is at stake

Jason Del Rey
By
Jason Del Rey
Jason Del Rey
Tech Correspondent
Down Arrow Button Icon
Jason Del Rey
By
Jason Del Rey
Jason Del Rey
Tech Correspondent
Down Arrow Button Icon
August 15, 2024, 9:00 AM ET
The three founders of Photon Health sitting on a brown sofa and posing for a photo.
Photon Health co-founders from left to right: Otto Sipe, Michael Rado, and Sam KotloveCourtesy of Photon Health

There’s a reason why most startup ideas focused on modernizing the prescription drug industry have failed: a byzantine system dominated by a group of all-powerful middlemen make an upstart’s chances of success infinitesimal. 

Recommended Video

Otto Sipe knows this well from nearly a decade of working for both startups and Walmart in and around the pharmacy and medical care spaces. But he thinks he has the right recipe and momentum to prove that he and his Brooklyn-based company can be one of the exceptions.

Sipe is the co-founder and CEO of Photon Health, a Brooklyn-based startup founded in 2021 that’s long term mission is to make shopping around for the best prices on prescription drugs as straightforward and convenient as online shopping for other products is today. In his telling, that long-term mission would one day manifest itself with the creation of an online marketplace where customers can go to browse the prices and in-stock availability of their prescription medications across pharmacies and choose from options including pharmacy pickup or on-demand home delivery. The hope is by increasing transparency, it might lead to competitive pressure to lower prices.

In short, the mission is to give some power back to the patients who are at the mercy of the $700 billion prescription drug market in the U.S. today. But to do that, Photon will likely need to secure buy-in from the giants of the pharmacy business. And that will take leverage. A lot of leverage.

“The cold-start phenomenon of a marketplace is very, very hard,” Sipe said. 

So the startup has entered the space in perhaps a counterintuitive way: by giving patients digital control of their prescriptions so they can easily pivot if their regular pharmacy doesn’t have their medication in-stock, is charging too much, or runs into some other issue filling the script.

This is how the model works. Photon sells so-called e-prescribing software to doctor’s offices and other health providers that allow them to send out a digital prescription for medication. Typically, a doctor would send an electronic prescription directly to a pharmacy but that can turn into a headache if the medication is out of stock or there’s another issue filling it, with a patient needing to get back in touch with a doctor’s office to reroute the electronic prescription to another pharmacy. These stresses compound if a physical doctor’s office is closed. 

Instead, doctors who use Photon send their patients an electronic prescription via a text message. The Photon website then lets the patient, or customer, choose from a variety of pharmacies that might include a national chain like Walgreens, a local independent pharmacy, or a modern mail-order provider like Amazon Pharmacy. When the medication is ready for pickup or has been delivered, Photon sends the customer an alert. Photon doesn’t currently route prescriptions for medications that qualify as controlled substances, but Sipe said his company will start doing so in 2025.

Thus far, Photon has focused on building its prescriber base by selling to virtual health providers like Sesame, Summer Health, and WeightWatchers’ clinic arm. In total, Photon is handling more than 70,000 electronic prescriptions in its network each month. That early momentum is important to investors like Nick Chirls, a partner at Notation Capital, a “pre-seed” investor that has now invested more than $3 million into the startup – the most funding his decade-old firm has ever invested in a single company. 

“If you can give patients control and visibility over their scripts, they can eventually go shopping like in any other area of ecommerce,” Chirls said in an interview with Fortune. “What does it mean when they can go shopping? They can choose drugs at the cheapest price from the most convenient place that actually has their drugs.”

Notation and the healthcare-focused firm Flare Capital Partners recently led a $9 million round in Photon Health. The startup has now raised north of $16 million in total from these firms and other VCs like Box Group, as well as angel investors including the founders of healthcare-related upstarts like Carbon Health and PillPack, which Amazon purchased for around $1 billion in 2018.

The main incumbent Photon is going after is Surescripts, a literal monopoly that makes software that doctors and other providers use to both deliver electronic prescriptions to pharmacies, and to check a patient’s eligibility for their insurance to cover a specific drug. The Federal Trade Commission sued the company in 2019, alleging that it was illegally maintaining a monopoly – a 95 percent “supershare” to be exact –– through anticompetitive behaviors, including exclusivity agreements. The two sides reached a settlement last year. 

“This is a crazy bet for people who work in health care,” Sipe said of Photon. “Surescripts is the untouchable monopoly…and there’s a battlefield littered with startups that have tried to take these guys out.”

“We don’t think we’re smarter than anyone else,” he added. “But we do think we have a different approach at a different point in time…and consumer demand for a better experience is so strong that that’s enough leverage to finally get over the hill.”

Fortune Brainstorm AI returns to San Francisco Dec. 8–9 to convene the smartest people we know—technologists, entrepreneurs, Fortune Global 500 executives, investors, policymakers, and the brilliant minds in between—to explore and interrogate the most pressing questions about AI at another pivotal moment. Register here.
About the Author
Jason Del Rey
By Jason Del ReyTech Correspondent
LinkedIn iconTwitter icon

Jason Del Rey is a technology correspondent at Fortune and a co-chair of the Fortune Brainstorm Tech and Fortune Brainstorm AI conferences.

See full bioRight Arrow Button Icon

Latest in Tech

AIMeta
It’s ‘kind of jarring’: AI labs like Meta, Deepseek, and Xai earned some of the worst grades possible on an existential safety index
By Patrick Kulp and Tech BrewDecember 5, 2025
7 hours ago
Elon Musk
Big TechSpaceX
Musk’s SpaceX discusses record valuation, IPO as soon as 2026
By Edward Ludlow, Loren Grush, Lizette Chapman, Eric Johnson and BloombergDecember 5, 2025
7 hours ago
data center
EnvironmentData centers
The rise of AI reasoning models comes with a big energy tradeoff
By Rachel Metz, Dina Bass and BloombergDecember 5, 2025
7 hours ago
netflix
Arts & EntertainmentAntitrust
Hollywood writers say Warner takeover ‘must be blocked’
By Thomas Buckley and BloombergDecember 5, 2025
7 hours ago
person
CybersecurityDigital
Dictionaries’ words of the year are trying to tell us something about being online in 2025
By Roger J. KreuzDecember 5, 2025
8 hours ago
Greg Peters
Big TechMedia
Top analyst says Netflix’s $72 billion bet on Warner Bros. isn’t about the ‘death of Hollywood’ at all. It’s really about Google
By Nick LichtenbergDecember 5, 2025
10 hours ago

Most Popular

placeholder alt text
Economy
Two months into the new fiscal year and the U.S. government is already spending more than $10 billion a week servicing national debt
By Eleanor PringleDecember 4, 2025
2 days ago
placeholder alt text
Success
‘Godfather of AI’ says Bill Gates and Elon Musk are right about the future of work—but he predicts mass unemployment is on its way
By Preston ForeDecember 4, 2025
2 days ago
placeholder alt text
Success
Nearly 4 million new manufacturing jobs are coming to America as boomers retire—but it's the one trade job Gen Z doesn't want
By Emma BurleighDecember 4, 2025
2 days ago
placeholder alt text
Success
Nvidia CEO Jensen Huang admits he works 7 days a week, including holidays, in a constant 'state of anxiety' out of fear of going bankrupt
By Jessica CoacciDecember 4, 2025
2 days ago
placeholder alt text
Real Estate
‘There is no Mamdani effect’: Manhattan luxury home sales surge after mayoral election, undercutting predictions of doom and escape to Florida
By Sasha RogelbergDecember 4, 2025
1 day ago
placeholder alt text
Economy
Tariffs and the $38 trillion national debt: Kevin Hassett sees ’big reductions’ in deficit while Scott Bessent sees a ‘shrinking ice cube’
By Nick LichtenbergDecember 4, 2025
1 day ago
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • Future 50
  • World’s Most Admired Companies
  • See All Rankings
Sections
  • Finance
  • Leadership
  • Success
  • Tech
  • Asia
  • Europe
  • Environment
  • Fortune Crypto
  • Health
  • Retail
  • Lifestyle
  • Politics
  • Newsletters
  • Magazine
  • Features
  • Commentary
  • Mpw
  • CEO Initiative
  • Conferences
  • Personal Finance
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
About Us
  • About Us
  • Editorial Calendar
  • Press Center
  • Work At Fortune
  • Diversity And Inclusion
  • Terms And Conditions
  • Site Map

© 2025 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.