• Home
  • News
  • Fortune 500
  • Tech
  • Finance
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia
TechSilicon Valley Bank

The Silicon Valley Bank meltdown could be a disaster for downtrodden biotech startups

By
Angelica Peebles
Angelica Peebles
,
Ilena Peng
Ilena Peng
and
Bloomberg
Bloomberg
Down Arrow Button Icon
By
Angelica Peebles
Angelica Peebles
,
Ilena Peng
Ilena Peng
and
Bloomberg
Bloomberg
Down Arrow Button Icon
March 10, 2023, 5:44 PM ET
Scientists working.
Scientists working. janiecbros—Getty images

Biotech companies are racing to assess the damage from the failure at SVB Financial Group, the latest issue facing many of the startups in search of cash. 

SVB, which collapsed Friday after a run on assets, plays a large role in financing early-stage life sciences and health-care companies. Venture-backed health companies account for 12% of SVB’s $173 billion of deposits and 36% of $168 billion in funds held off balance sheets as of year-end.

The SPDR S&P Biotech ETF closed down 3.9% while the Nasdaq Biotechnology Index fell 1.6%. The S&P 500 slipped 1.5%.

Like technology companies, biotech companies found themselves in a tough spot trying to decide what to do with money held at SVB, “an important financial partner” for the industry, John Maraganore, the former Alnylam Pharmaceuticals Inc. chief who’s involved with multiple investment firms and biotech boards, said in an interview.

The collapse of the best-known bank for venture-backed firms brings yet another blow for the industry contending with a prolonged downturn. Biotech companies had already been under intense pressure for more than a year as pandemic-fueled growth cooled and investors began to shun risky assets amid rising interest rates. 

Most biotechs have assessed their exposure and started developing ways to mitigate it, Maraganore said early Friday. He said the last 24 hours were full of email exchanges and board calls about how to proceed. 

Venture Capital

Labs at a startup incubator in Cambridge were abuzz Friday morning as SVB’s downfall appeared imminent, said Isaac Stoner, chief executive officer of closely held Octagon Therapeutics. 

“Folks in the lab, folks in the office, everyone is talking about this,” he said. 

Venture capital firms that fund other types of emerging health companies also felt SVB’s tremors. Bill Geary, co-founder at Flare Capital Partners, a venture firm focused on early-stage health technology investments, said all the firm’s portfolio companies were somewhat affected. Geary called the implications “profound” since SVB has played such an important role in the health-care ecosystem. As interest rates continue to rise, SVB’s meltdown could contribute to even more pessimism about the ability to raise capital, Geary said. 

“You can’t just look at any one of these things in isolation,” he said. “They all have kind of a compounded negative impact. This is just one example of how a financial institution that’s important in the value chain has been so dramatically impacted by rising interest rates.” 

So far, public biotech companies appear shielded from the brunt of the damage. Most of those Evercore ISI analyst Josh Schimmer surveyed said they have limited exposure and aren’t expecting any material risks to their balance sheets. 

“I’ve not found any company yet that has any material risk from this perspective, but there may be some disruption along the way,” Schimmer said Friday in a discussion on Twitter spaces. 

Fortune's CFO Daily newsletter is the must-read analysis every finance professional needs to get ahead. Sign up today.
About the Authors
By Angelica Peebles
See full bioRight Arrow Button Icon
By Ilena Peng
See full bioRight Arrow Button Icon
By Bloomberg
See full bioRight Arrow Button Icon

Latest in Tech

Elon Musk
Big TechSpaceX
SpaceX to offer insider shares at record-setting $800 billion valuation
By Edward Ludlow, Loren Grush, Lizette Chapman, Eric Johnson and BloombergDecember 6, 2025
5 hours ago
Big TechApple
Apple rocked by executive departures, with chip chief at risk of leaving next
By Mark Gurman and BloombergDecember 6, 2025
8 hours ago
Nvidia CEO Jensen Huang said China is better equipped for an AI data center buildout than the U.S.
AITech
Nvidia CEO says data centers take about 3 years to construct in the U.S., while in China ‘they can build a hospital in a weekend’
By Nino PaoliDecember 6, 2025
10 hours ago
Arts & EntertainmentMedia
Former Amazon Studios boss warns the Netflix-Warner Bros. deal will make Hollywood ‘a system that circles a single sun’
By Jason MaDecember 6, 2025
11 hours ago
Jay Clayton
LawCrime
25-year DEA veteran charged with helping Mexican drug cartel launder millions of dollars, secure guns and bombs
By Dave Collins, Michael R. Sisak and The Associated PressDecember 6, 2025
12 hours ago
Elon Musk
LawSocial Media
Elon Musk’s X fined $140 million by EU for breaching digital regulations
By Kelvin Chan and The Associated PressDecember 6, 2025
12 hours ago

Most Popular

placeholder alt text
Big Tech
Mark Zuckerberg rebranded Facebook for the metaverse. Four years and $70 billion in losses later, he’s moving on
By Eva RoytburgDecember 5, 2025
1 day ago
placeholder alt text
AI
Nvidia CEO says data centers take about 3 years to construct in the U.S., while in China 'they can build a hospital in a weekend'
By Nino PaoliDecember 6, 2025
10 hours ago
placeholder alt text
Success
Nvidia CEO Jensen Huang admits he works 7 days a week, including holidays, in a constant 'state of anxiety' out of fear of going bankrupt
By Jessica CoacciDecember 4, 2025
2 days ago
placeholder alt text
Economy
Two months into the new fiscal year and the U.S. government is already spending more than $10 billion a week servicing national debt
By Eleanor PringleDecember 4, 2025
3 days ago
placeholder alt text
Success
‘Godfather of AI’ says Bill Gates and Elon Musk are right about the future of work—but he predicts mass unemployment is on its way
By Preston ForeDecember 4, 2025
3 days ago
placeholder alt text
Real Estate
The 'Great Housing Reset' is coming: Income growth will outpace home-price growth in 2026, Redfin forecasts
By Nino PaoliDecember 6, 2025
15 hours ago
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • Future 50
  • World’s Most Admired Companies
  • See All Rankings
Sections
  • Finance
  • Leadership
  • Success
  • Tech
  • Asia
  • Europe
  • Environment
  • Fortune Crypto
  • Health
  • Retail
  • Lifestyle
  • Politics
  • Newsletters
  • Magazine
  • Features
  • Commentary
  • Mpw
  • CEO Initiative
  • Conferences
  • Personal Finance
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
About Us
  • About Us
  • Editorial Calendar
  • Press Center
  • Work At Fortune
  • Diversity And Inclusion
  • Terms And Conditions
  • Site Map

© 2025 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.