• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia
HealthCOVID-19 vaccines

The COVID symptoms you get depend on how many vaccine jabs you’ve had, major study says

By
Chloe Taylor
Chloe Taylor
Down Arrow Button Icon
By
Chloe Taylor
Chloe Taylor
Down Arrow Button Icon
October 27, 2022, 8:02 AM ET
A woman holds a COVID-19 rapid self test device, which displays a positive result.
The COVID symptoms you get depend on how many vaccine doses you’ve had, according to a major study. d3sign/Getty Images

If you’ve ever had COVID, there’s a chance you’re all too familiar with symptoms of the virus, which include a cough, tiredness, and headaches.

But as the virus has evolved and new variants like Delta and Omicron have emerged, its most common symptoms have changed—and now, it seems, which ones you get depends on how many vaccine jabs you’ve had.

Getting vaccinated against COVID reduces your risk of severe illness, hospitalization, and death if you do catch the disease—but according to new research, it could also dictate which batch of the milder, more common symptoms of the virus you end up getting. It’s thought that a large proportion of cases are still asymptomatic.

In an update to the ongoing Zoe Health Study, which has collected data from almost 5 million participants since 2020, researchers said they had identified symptoms that had emerged in recent weeks, noting that they appeared to differ depending on vaccination status.

“Generally, we saw similar symptoms of COVID-19 being reported overall in the app by people who had and hadn’t been vaccinated,” the research team said in its update. “However, fewer symptoms were reported over a shorter period of time by those who had already had a jab, suggesting that they were falling less seriously ill and getting better more quickly.”

Symptoms by vaccination status

The most common current symptoms reported in those who were fully vaccinated, ranked by prevalence, were…

  1. Sore throat
  2. Runny nose
  3. Blocked nose
  4. Persistent cough
  5. Headache

“Traditional” symptoms from the early months of the pandemic, such as loss of smell, fever, and shortness of breath, ranked way down the list in those who had received two doses of a vaccine, researchers said, being named the sixth, eighth, and 29th most common COVID symptoms.

“Curiously, we noticed that people who had been vaccinated and then tested positive for COVID-19 were more likely to report sneezing as a symptom compared with those without a jab,” they added.

Among those who had only had one vaccine dose, the most common recent symptoms were slightly different:

  1. Headache
  2. Runny nose
  3. Sore throat
  4. Sneezing
  5. Persistent cough

In people who were unvaccinated, the study said, the symptoms were “more recognizable to the traditional original ranking,” though they acknowledged there had been some changes from when COVID first appeared.

If you haven’t had a dose of a COVID vaccine, the symptoms you’re most likely to get with the virus—according to the Zoe study—are…

  1. Headache
  2. Sore throat
  3. Runny nose
  4. Fever
  5. Persistent cough

“Loss of smell comes in at No. 9 and shortness of breath comes far down the list at No. 30, indicating the symptoms as recorded previously are changing with the evolving variants of the virus,” the research team said.

Being fully vaccinated and boosted against COVID lowers the risk of becoming severely ill with the virus, particularly if you’re also young and healthy.

However, it’s thought that the Omicron variant and its offspring—like BA.5, which is currently America’s dominant strain of the virus—cause milder illness than their predecessors, even in the unvaccinated.

Globally, COVID infections are on the rise, with experts predicting there will be an uptick in deaths as the Northern Hemisphere heads into its winter months.

In August, Dr. Anthony Fauci, the White House’s top medical adviser, urged Americans to get vaccinated or risk “getting into trouble” over the colder seasons.

Sign up for the Fortune Features email list so you don’t miss our biggest features, exclusive interviews, and investigations.

About the Author
By Chloe Taylor
LinkedIn iconTwitter icon
See full bioRight Arrow Button Icon

Latest in Health

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025

Most Popular

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Fortune Secondary Logo
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • Future 50
  • World’s Most Admired Companies
  • See All Rankings
Sections
  • Finance
  • Fortune Crypto
  • Features
  • Leadership
  • Health
  • Commentary
  • Success
  • Retail
  • Mpw
  • Tech
  • Lifestyle
  • CEO Initiative
  • Asia
  • Politics
  • Conferences
  • Europe
  • Newsletters
  • Personal Finance
  • Environment
  • Magazine
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
  • Group Subscriptions
About Us
  • About Us
  • Editorial Calendar
  • Press Center
  • Work At Fortune
  • Diversity And Inclusion
  • Terms And Conditions
  • Site Map
  • About Us
  • Editorial Calendar
  • Press Center
  • Work At Fortune
  • Diversity And Inclusion
  • Terms And Conditions
  • Site Map
  • Facebook icon
  • Twitter icon
  • LinkedIn icon
  • Instagram icon
  • Pinterest icon

Latest in Health

The 5 Best Weight Loss Pills of 2026: Expert and Doctor Approved
HealthDietary Supplements
The 5 Best Weight Loss Pills of 2026: Expert and Doctor Approved
By Emily PharesApril 10, 2026
2 hours ago
Ritual Synbiotic+ Probiotic Review (2026): An Expert’s Opinion
HealthDietary Supplements
Ritual Synbiotic+ Probiotic Review (2026): An Expert’s Opinion
By Christina SnyderApril 10, 2026
5 hours ago
‘Babies become sitting ducks’: Babies too young for vaccines remain vulnerable in measles ‘hotbed’ communities
HealthVaccine
‘Babies become sitting ducks’: Babies too young for vaccines remain vulnerable in measles ‘hotbed’ communities
By The Associated Press, Laura Ungar and Devi ShastriApril 10, 2026
6 hours ago
Legion Whey+ Protein Powder Review (2026): Nutrition Expert Approved
HealthDietary Supplements
Legion Whey+ Protein Powder Review (2026): Nutrition Expert Approved
By Christina SnyderApril 9, 2026
1 day ago
assis
CommentaryIBM
The digital sovereignty dilemma is a false choice — here’s how enterprises can have both
By Ana Paula AssisApril 9, 2026
1 day ago
Best Maca Root Supplements of 2026: Tester and Nutrition Expert Approved
HealthDietary Supplements
Best Maca Root Supplements of 2026: Tester and Nutrition Expert Approved
By Emily PharesApril 7, 2026
3 days ago

Most Popular

The U.S. government is spending $88 billion a month in interest on national debt—equal to spending on defense and education combined
Economy
The U.S. government is spending $88 billion a month in interest on national debt—equal to spending on defense and education combined
By Fortune EditorsApril 9, 2026
1 day ago
A Meta employee created a dashboard so coworkers can compete to be the company's No. 1 AI token user—and Zuckerberg doesn't even rank in the top 250
AI
A Meta employee created a dashboard so coworkers can compete to be the company's No. 1 AI token user—and Zuckerberg doesn't even rank in the top 250
By Fortune EditorsApril 9, 2026
1 day ago
Mark Cuban admits he made a mistake letting go of the Mavericks: 'I don't regret selling. I regret who I sold to'
Investing
Mark Cuban admits he made a mistake letting go of the Mavericks: 'I don't regret selling. I regret who I sold to'
By Fortune EditorsApril 9, 2026
1 day ago
'I hate working 5 days': Zoom CEO says traditional work schedules are becoming obsolete—and predicts a 3-day workweek by 2031
Success
'I hate working 5 days': Zoom CEO says traditional work schedules are becoming obsolete—and predicts a 3-day workweek by 2031
By Fortune EditorsApril 9, 2026
1 day ago
Schools across America are quietly admitting that screens in classrooms made students worse off and are reversing years of tech-first policies
Innovation
Schools across America are quietly admitting that screens in classrooms made students worse off and are reversing years of tech-first policies
By Fortune EditorsApril 10, 2026
12 hours ago
Gen Z doesn't want your full-time job. They want several part-time roles, and it's reshaping the entire workforce
Success
Gen Z doesn't want your full-time job. They want several part-time roles, and it's reshaping the entire workforce
By Fortune EditorsApril 9, 2026
2 days ago

© 2026 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.