• Home
  • News
  • Fortune 500
  • Tech
  • Finance
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia
Health

Takeda Finally Inks a Deal to Buy Shire in One of the Biggest Pharma Takeovers Ever

By
David Meyer
David Meyer
Down Arrow Button Icon
By
David Meyer
David Meyer
Down Arrow Button Icon
May 8, 2018, 3:45 AM ET

Japan’s Takeda Pharmaceutical is about to become a major international player on the biopharma scene, with its purchase of larger Irish rival Shire (SHPG).

It’s one of the biggest pharma deals in history, and the largest-ever international takeover by any Japanese company, at a value of $62 billion. And it brings to a close a tense bidding saga that saw the Adderall-maker reject Takeda’s advances four times over.

The deal gives Takeda (TKPYY), a gastroenterology and cancer specialist, greater access to the U.S. market, while Shire’s portfolio will get greater exposure in Japan and emerging markets, the companies said Tuesday.

Takeda’s shares climbed 4% and Shire’s 3% on the news.

A few weeks ago, Takeda confirmed that it was trying to buy out Shire, a specialist in treating rare diseases, by noting that its most recent proposal had been spurned. At that point, Botox firm Allergan (AGN) said it was also considering a bid for Shire—but followed up mere hours later by saying it had decided against it.

Less than a week later, Shire’s board recommended Takeda’s takeover proposal. With Takeda’s shareholders responding negatively, sending the company’s stock price down 7%, the question then was whether the preliminary agreement would hold up.

It did. On Tuesday—the deadline for the deal—Takeda formalized its offer. It will pay $66.56 per Shire share: $30.33 in cash, with the remainder in the form of 0.839 of a new Takeda share.

Takeda and Shire said they expect the deal to close in the first half of next year, with Takeda’s shareholders owning about half of the combined operation.

“Shire’s highly complementary product portfolio and pipeline, as well as experienced employees, will accelerate our transformation for a stronger Takeda,” said Takeda CEO Christophe Weber. “Together, we will be a leader in providing targeted treatments in gastroenterology, neuroscience, oncology, rare diseases and plasma-derived therapies.”

Takeda will become the only pharma company with dual listings in Tokyo and New York. The combined operation will also expand its research and development efforts in the Boston area, the companies said.

About the Author
By David Meyer
LinkedIn icon
See full bioRight Arrow Button Icon

Latest in Health

HealthHealth
These toxic wild mushrooms have caused a deadly outbreak of poisoning in California
By The Associated PressDecember 7, 2025
18 hours ago
Schumer
Politicsnational debt
‘This is a bad idea made worse’: Senate Dems’ plan to fix Obamacare premiums adds nearly $300 billion to deficit, CRFB says
By Nick LichtenbergDecember 5, 2025
3 days ago
Best vegan meal delivery
Healthmeal delivery
Best Vegan Meal Delivery Services of 2025: Tasted and Reviewed
By Christina SnyderDecember 5, 2025
3 days ago
Retailmeal delivery
Best Prepared Meal Delivery Services of 2025: RD Approved
By Christina SnyderDecember 5, 2025
3 days ago
Gen Z
EconomyGen Z
America, meet your alienated youth: ‘Gold standard’ Harvard survey reveals Gen Z’s anxiety and distrust, defined by economic insecurity
By Nick LichtenbergDecember 4, 2025
4 days ago
Jensen Huang
SuccessBillionaires
Nvidia CEO Jensen Huang admits he works 7 days a week, including holidays, in a constant ‘state of anxiety’ out of fear of going bankrupt
By Jessica CoacciDecember 4, 2025
4 days ago

Most Popular

placeholder alt text
Real Estate
The 'Great Housing Reset' is coming: Income growth will outpace home-price growth in 2026, Redfin forecasts
By Nino PaoliDecember 6, 2025
2 days ago
placeholder alt text
AI
Nvidia CEO says data centers take about 3 years to construct in the U.S., while in China 'they can build a hospital in a weekend'
By Nino PaoliDecember 6, 2025
2 days ago
placeholder alt text
Economy
The most likely solution to the U.S. debt crisis is severe austerity triggered by a fiscal calamity, former White House economic adviser says
By Jason MaDecember 6, 2025
1 day ago
placeholder alt text
Economy
JPMorgan CEO Jamie Dimon says Europe has a 'real problem’
By Katherine Chiglinsky and BloombergDecember 6, 2025
1 day ago
placeholder alt text
Politics
Supreme Court to reconsider a 90-year-old unanimous ruling that limits presidential power on removing heads of independent agencies
By Mark Sherman and The Associated PressDecember 7, 2025
18 hours ago
placeholder alt text
Big Tech
Mark Zuckerberg rebranded Facebook for the metaverse. Four years and $70 billion in losses later, he’s moving on
By Eva RoytburgDecember 5, 2025
3 days ago
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • Future 50
  • World’s Most Admired Companies
  • See All Rankings
Sections
  • Finance
  • Leadership
  • Success
  • Tech
  • Asia
  • Europe
  • Environment
  • Fortune Crypto
  • Health
  • Retail
  • Lifestyle
  • Politics
  • Newsletters
  • Magazine
  • Features
  • Commentary
  • Mpw
  • CEO Initiative
  • Conferences
  • Personal Finance
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
About Us
  • About Us
  • Editorial Calendar
  • Press Center
  • Work At Fortune
  • Diversity And Inclusion
  • Terms And Conditions
  • Site Map

© 2025 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.