Police killed the shooter, who was identified as Omar S. Mateen, a Florida resident. A top U.S. congressman said Mateen may have pledged allegiance to the Islamic State militant group.

U.S. officials cautioned, however, that they had no immediate evidence of any direct connection with Islamic State or any other foreign extremist group.

Fifty-three people were wounded in the rampage, which Orlando Mayor Buddy Dyer said was the deadliest single U.S. shooting incident, eclipsing the 32 people killed in the 2007 massacre at Virginia Tech university.

“Today we’re dealing with something that we never imagined and is unimaginable,” Dyer said, more than doubling an earlier estimate that about 20 bodies had been found.

A police officer working as a security guard inside the Pulse nightclub, which has operated in downtown Orlando since 2004 and was hosting some 350 revelers, exchanged fire with the suspect at about 2 a.m. ET, police officials said.

“Everyone get out of pulse and keep running,” the club’s management wrote on Facebook as the incident unfolded.

A hostage situation developed, and three hours later SWAT team officers used armored cars to storm the club before shooting dead the gunman. It was unclear when the victims were killed.

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Dozens of terrified patrons, some of whom had been hiding in restrooms, were rescued. One officer was injured when he was hit in his helmet while exchanging fire with the gunman, police said.

Representative Adam Schiff, the top Democrat on a congressional intelligence committee, noted that the shooting took place during Ramadan, and that ISIS leaders in Syria have urged attacks during this time.

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If confirmed as an act of terrorism, it would stand as the deadliest such attack on U.S. soil since Sept. 11, 2001, when al Qaeda-trained hijackers crashed jetliners into New York’s World Trade Center, the Pentagon and a field in Pennsylvania, killing some 3,000 people.

A pair of ethnic Chechen brothers killed three people and injured more than 260 with a pair of homemade pressure-cooker bombs at the Boston Marathon in April 2013

Asked if the FBI suspected the gunman might have had inclinations toward militant Islam, including a possible sympathy for Islamic State, Ronald Hopper, an assistant FBI agent in charge, told reporters: “We do have suggestions that the individual may have leanings toward that particular ideology. But right now we can’t say definitively.”