• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia

Trendingnow

1

After 40 investors rejected Jeff Bezos’ Amazon pitch, his parents offered $245,573 of their retirement savings

2

China now makes up a record 40% of all global container exports—and it’s a sign Trump’s tariffs meant to punish Chinese firms have fallen flat

3

Billionaire Nike cofounder Phil Knight gives $1 billion to his alma mater: ‘This is no time to abandon’ higher education

1

After 40 investors rejected Jeff Bezos’ Amazon pitch, his parents offered $245,573 of their retirement savings

2

China now makes up a record 40% of all global container exports—and it’s a sign Trump’s tariffs meant to punish Chinese firms have fallen flat

3

Billionaire Nike cofounder Phil Knight gives $1 billion to his alma mater: ‘This is no time to abandon’ higher education

The venture capital surprise

By
Dan Primack
Dan Primack
Down Arrow Button Icon
By
Dan Primack
Dan Primack
Down Arrow Button Icon
July 11, 2011, 1:19 PM ET
Google source logo
Add Fortune on Google for similar content.

New research on the VC industry turns conventional wisdom on its head.



In the world of venture capital, tech is the movie star and life sciences the second banana. The champion and the also-ran. Just look at the most recent Forbes Midas List, in which the first life sciences investor doesn’t appear until #16 (Bryan Roberts of Venrock).

But new research suggests that this hierarchy has quietly reversed itself over the past decade.

Venture capitalists Bruce Booth (Atlas Venture) and Bijan Salehizadeh (Highland Capital Partners) recently analyzed the past 10 years of returns from nearly 1,300 VC firms, on a deal-by-deal basis. What they found was that VC investments into U.S. life sciences companies between 2000 and 2010 yielded a gross pooled mean IRR of 15% for realized deals and 7.4% once unrealized deals were included. This compares to a 3% IRR for realized IT deals over the same time period, a 4.1% IRR for realized software deals.

Moreover, each sub-category of life sciences deals came in at least 2x better than did realized results of IT sub-categories. All of this is a complete reversal of the 1990s, when IT deal performance absolutely dominated life sciences deal performance. And it holds even if you remove deals done in 2000, which was just before the dotcom bubble burst.

“There is a widely-held perception among both GPs and LPs that life sciences is venture capital’s ugly stepchild compared to tech,” says Booth. “So we were surprised to find what we did.”

Four notes on the study:

  1. 1. The data is based on deals, not on funds. As such, it does not necessarily mean that funds dedicated to life sciences outperform funds dedicated to IT. Some of the strongest life sciences deals may have come from generalist firms.
  2. 2. The data only goes through the end of 2010, so does not include this year’s big tech IPOs like LinkedIn, Pandora, etc.
  3. 3. Some readers complained about selection bias in a prior piece I wrote utilizing Cambridge Associates data. Please remember that CA data is based on fund financial statements (not surveys), and often comes from CA’s LP clients (i.e., not GP-directed).
  4. 4. Booth and Salehizadeh have published their entire paper in the new issue of Nature Biotechnology, out today.



About the Author
By Dan Primack
See full bioRight Arrow Button Icon

Latest in


Most Popular

Fortune Secondary Logo
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • World's Most Admired Companies
  • See All Rankings
  • Lists Calendar
Sections
  • Finance
  • Fortune Crypto
  • Features
  • Leadership
  • Health
  • Commentary
  • Success
  • Retail
  • Mpw
  • Tech
  • Lifestyle
  • CEO Initiative
  • Asia
  • Politics
  • Conferences
  • Europe
  • Newsletters
  • Personal Finance
  • Environment
  • Magazine
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
  • Group Subscriptions
About Us
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • Facebook icon
  • Twitter icon
  • LinkedIn icon
  • Instagram icon
  • TikTok icon
  • YouTube icon

    Latest in


    Most Popular

    © 2026 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
    FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.