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Vaccines

An FDA panel has endorsed 2 RSV vaccines for older Americans. Here’s when they might be available

By
Erin Prater
Erin Prater
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By
Erin Prater
Erin Prater
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March 2, 2023, 3:43 PM ET
Updated March 3, 2023, 11:54 AM ET
A U.S. Food and Drug Administration panel Wednesday voted to endorse GlaxoSmithKline's RSV vaccine for older adults, after voting to endorse one from Pfizer earlier in the week.
A U.S. Food and Drug Administration panel Wednesday voted to endorse GlaxoSmithKline's RSV vaccine for older adults, after voting to endorse one from Pfizer earlier in the week.Getty Images

Key takeaways

  • A U.S. Food and Drug Administration panel endorsed 2 RSV vaccines for older adults this week.
  • RSV kills between 6,000 and 10,000 elderly adults in the U.S. each year.
  • Shots are for adults 60 and older and could be available as soon as this summer.

A U.S. Food and Drug Administration panel Wednesday voted to endorse GlaxoSmithKline’s RSV vaccine for older adults, after voting to endorse one from Pfizer earlier in the week.

The panel voted unanimously to recommend GSK’s vaccine against the common winter respiratory virus, sometimes severe in the elderly and the young. It voted 7-4 Tuesday to recommend one from Pfizer. 

Both jabs would be available for adults 60 and older—and they could be ready as soon as this summer, Dr. Ali Alhassani, head of clinical at Summer Health, tells Fortune.

The panel’s recommendations are usually adopted by the FDA. If approved by the FDA, the U.S. Centers for Disease Control and Prevention will issue an immunization schedule.

Pfizer is also seeking approval for an RSV vaccine for pregnant individuals, to provide protection for infants from birth through the first six months of life. It showed 82% effectiveness through 90 days of life, and 69% effectiveness through six months, Pfizer announced in November, citing Phase III clinical trial data. The FDA is set to review the vaccine by August, according to the company.

RSV, or respiratory syncytial virus infection, is a common illness that usually presents as a mild cold. Almost everyone has been infected with it by age 2, according to the CDC. 

But RSV isn’t mild for everyone. The virus hospitalizes tens of thousands of infants, young children, and elderly adults each year in the U.S. And it kills between 6,000 and 10,000 elderly adults in the U.S. each year, according to the national public health agency.

Symptoms can range from cold-like ailments such as sneezing, sore throat, fever, and stuffy nose, to bronchiolitis and pneumonia, the latter of which can prove fatal. What’s more, patients can quickly take a turn for the worse. 

RSV can also exacerbate the symptoms of people with chronic health problems like asthma, chronic obstructive pulmonary disease (COPD), or congestive heart failure, according to the CDC.

Those at highest risk of a severe outcome from RSV, according to the CDC, include:

  • Older adults 65+
  • Infants 6 months and younger
  • Prematurely born infants
  • Older adults and children younger than 2 with chronic heart or lung disease
  • Older adults and children with weakened immune systems
  • Children with neuromuscular disorders, such as those who have difficulty swallowing or clearing mucus

Cases of RSV are leveling out after a spike in November. The virus, along with COVID and flu, was part of what some public health officials called a “tripledemic” late last year that put hospital capacity in jeopardy as viral circulation spiked, likely as a result of the lifting of pandemic restrictions. While the impact on the U.S. health system was significant, other factors like general hospital bed availability and a shortage of health care workers contributed, and levels of RSV were not unusually high, experts say.

While RSV is a common winter virus, it can occur at any time of year. COVID disrupted the seasonal patterns of many viruses, resulting in oddly elevated RSV levels spring through fall of 2021.

Editor’s note: This article was updated at 10:24 a.m. ET March 3, 2023, to reflect that the FDA committee recommended one dose of each company’s vaccine.

About the Author
By Erin Prater
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