Sarah London

When Sarah London became CEO of Centene in March 2022 at 41 years old, she was the youngest woman to take the helm of a Fortune 500 company—and she hasn’t been dethroned yet. Over the past four years, she’s steered the nation’s largest Medicaid insurer through one of the most turbulent periods in the history of American health care. From $900 billion in cuts to Medicaid over 10 years to reduced eligibility for Affordable Care Act Marketplace plans, federal budget cuts were just one challenge for the $195-billion-in-revenue company. It posted a $6.7 billion loss last year amid this new reality, mostly owing to a one-time write-down. London had to pull earnings guidance last year—and the company’s stock fell 40% in one day (though it has started to recover). Investors seem confident in London’s leadership through the choppy waters. Read more: The youngest-ever female CEO of a Fortune 500 company is fighting Trump’s cuts to keep Medicaid strong