Debra Crew

After two years running Reynolds American’s largest subsidiary, Crew became the company’s CEO in January, succeeding former chief Susan Cameron in the first female-to-female chief transfer of power in the S&P 500 since 2012. Crew’s move to the corner office, however, came in the midst of the company’s ­acquisition by British American Tobacco. Crew now ­reports to BAT’s CEO, though she remains at the helm of Reynolds, which becomes BAT’s largest profit center—with net income up 87% to $6.1 billion last year.