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F500-2023-040-Johnson-and-Johnson

The health care company is best known for household items like baby shampoo and Tylenol, but pharmaceuticals and medical technology are its big revenue drivers, bringing in $52.5 billion and $27.4 billion respectively, compared to $14.9 billion in the consumer health segment. 
<ul> 
 	<li>Revenue inched up 1.2% to $94.9 billion in 2022, but profits fell 14.1% to $17.9 billion.</li> 
 	<li>The U.S. government phased out Johnson &amp; Johnson’s one-shot COVID vaccine, hurting the company’s pharmaceutical division.</li> 
 	<li>In April 2023, the company settled a decade-long legal dispute in which consumers accused J&amp;J’s iconic baby powder of causing cancer. The company agreed to pay $8.9 billion to tens of thousands of plaintiffs but has not admitted wrongdoing. Before the settlement is final, a court must accept a controversial bankruptcy filing by a subsidiary that Johnson &amp; Johnson created to shield its corporate assets from litigation. A court rejected an earlier bankruptcy filing aimed at reaching a settlement, which allowed thousands of related cases against J&amp;J to go ahead.</li> 
</ul>

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WMAC-2022-17-Johnson and Johnson

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WMAC 2021-15-Johnson & Johnson

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G500-2021-094-Johnson & Johnson

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G500-2020-104-JJ

The sprawling 134-year-old health conglomerate eked out 0.6% sales growth in 2019 thanks to the strong performance of its pharmaceutical business, and particularly its immunology and oncology drugs. J&amp;J’s consumer business—with a portfolio that includes Neutrogena, Tylenol, and Listerine—was boosted by the acquisition of Zarbee’s, a purveyor of naturally based over-the-counter remedies. The company continued its push into the robotic surgery market in an effort to revive its struggling medical device business. J&amp;J is also mired in litigation surrounding its opioid and baby powder products. (In May, it announced it would stop selling talc-based baby powder.) While COVID-19 has dinged sales of some of its products—like contact lenses and artificial knees and hips—the company is one of the frontrunners in the race for a vaccine; J&amp;J has said it hopes to begin late-stage human trials by the end of September.

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F500-2020-035-Johnson and Johnson

The sprawling 134-year-old health conglomerate eked out 0.6% sales growth in 2019 thanks to the strong performance of its pharmaceutical business, and particularly its immunology and oncology drugs. J&amp;J’s consumer business—with a portfolio that includes Neutrogena, Tylenol, and Listerine—was boosted by the acquisition of Zarbee’s, a purveyor of naturally based over-the-counter remedies. The company continued its push into the robotic surgery market in an effort to revive its struggling medical device business. J&amp;J is also mired in litigation surrounding its opioid and baby powder products. No surprise, the company has been impacted by COVID-19 in various ways; while its pharma division is racing to develop a vaccine, sales of products like artificial knees and hips are down due to the cancellation of elective surgeries during the pandemic.

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Global business is back. After limping through a worldwide financial crisis and economic slowdown, the 500 largest companies ranked by revenues shattered all sorts of performance records in 2013: They racked up combined revenues of $31.1 trillion, up 2.5% from 2012, and profits soared 27% to nearly $2 trillion. China’s 95 companies (up from 89 last year) posted $5.8 trillion in revenues. The U.S. has four fewer companies on the list than last year but remains (for now) the country leader, with 128 corporations on the list—including No. 1 Wal-Mart Stores—reporting $8.6 trillion in revenues. 

Wal-Mart stayed on top as its sales crept closer to half-a-trillion dollars. Apple moved into the top five. And UnitedHealth Group continued its steady climb. 

Best Companies To Work For Europe

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Johnson &amp; Johnson, founded in 1886, is among the world’s largest and most influential health care companies. It is involved in the research, development, manufacture, and distribution of innovative medicines and medical technologies. The company’s innovative medicine business operates in areas including oncology, immunology, neuroscience, and cardiopulmonary treatment. In medtech, the company is focused on developing and delivering cardiovascular, orthopedics, surgery, and vision solutions.

Q2 2026

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Johnson & Johnson (JNJ): Company Profile, Stock Price, News, Rankings

legacy

Johnson & Johnson

johnson & johnson

Good morning. Welcome to Johnson & Johnson's second quarter 2026 earnings conference call. All participants will be in a listen-only mode until the question-and-answer session of the conference. This call is being recorded. If anyone has any objections, you may disconnect at this time. If you experience technical difficulties during the conference, you may press star zero to reach the operator. I will now turn the conference call over to Johnson & Johnson. You may begin.

Hello, everyone. This is Ryan Koors, Vice President of Investor Relations for Johnson & Johnson. I'm excited to be here today and to lead the Investor Relations team moving forward. Welcome to our company's review of business results for the second quarter of 2026 and our financial outlook for the full year. First, a few logistics. As a reminder, today's presentation and associated schedules are available on the Investor Relations section of the Johnson & Johnson website at investor.jnj.com. Please note that this presentation contains forward-looking statements regarding, among other things, the company's future operating and financial performance, market position, and business strategy. You are cautioned not to rely on these forward-looking statements, which are based on the current expectations of future events using the information available as of the date of this recording.

They are subject to certain risks and uncertainties that may cause the company's actual results to differ materially from those projected. The description of these risks, uncertainties, and other factors can be found in our SEC filings, including our 2025 Form 10-K, which is available at investor.jnj.com and on the SEC's website. Additionally, several of the products and compounds discussed today are being developed in collaboration with strategic partners or licensed from other companies. This slide acknowledges those relationships. Moving to today's agenda. Joaquin Duato, our Chairman and CEO, will discuss our business performance and growth drivers. I will then review the second quarter sales and P&L results. Joe Wolk, our CFO, will close by sharing an overview of our capital allocation priorities and updated guidance for 2026.

Jennifer Taubert, Executive Vice President, Worldwide Chairman, Innovative Medicine; John Reed, Executive Vice President, Innovative Medicine Research and Development; and Tim Schmid, Executive Vice President, Worldwide Chairman, MedTech, will be joining us for Q&A. To ensure we provide enough time to address your questions, we anticipate the webcast will last approximately 60 min. With that, I will now turn the call over to Joaquin.

Thank you, Ryan, and welcome to your new role. I'm pleased to share the top-line results from our strong second quarter. We said 2026 would be a year of accelerated growth and impact for Johnson & Johnson, and with our Q2 beat on the top and bottom line and raised guidance, we are delivering. Across oncology, immunology, neuroscience, cardiovascular surgery ambition, the strength of our business is built on our unique combination of scientific expertise, scale, and disciplined execution. We have the strongest portfolio and pipeline in our 140 yr history, with 28 products and platforms that each deliver more than $1 billion in annual sales. In Q2, we reported operational sales growth of 5.6%. Excluding STELARA, we grew double digits in the quarter.

With sales in the quarter of more than $25 billion, we are on track to meet our 2026 target of more than $100 billion in annual revenue for the first time in our company's 140 yr history. We are pleased with the progress of our new launches, including ICOTYDE, INLEXZO, and RYBREVANT, instilling confidence that momentum will accelerate into 2027 and beyond, with line of sight to double-digit growth by the end of the decade. ICOTYDE, in particular, has significant early launch momentum, with uptake accelerating and performance outpacing competitors at comparable points in their launches. Since launch, more than 10,000 patients have initiated therapy on ICOTYDE, underscoring the unmet need for patients seeking first-line systemic treatment with a unique combination of efficacy, safety, and the simplicity of a once-daily pill. In Innovative Medicine, we delivered operational sales growth of 6.8% in the quarter, with eight brands growing double digits.

In oncology, our commitment to transform patient outcomes has never been stronger. We are on track to be the number one oncology company by 2030, with sales projected to exceed $50 billion. Leading the way in Q2 is DARZALEX, the foundational treatment for multiple myeloma, which continues to be our largest product. Once again, DARZALEX delivered sales of more than $4 billion, growing close to 18%. When we talk about the depth of our portfolio, nowhere is that more evident than in multiple myeloma. We have treatments in every line of therapy, with 80% of patients receiving one or more of our medicines during their treatment journey. CARVYKTI, TECVAYLI, and TALVEY continue to deliver high double-digit growth.

We are not standing still, with the new data this quarter showing the combination of TALVEY and DARZALEX delivered deep and durable responses with more than 80% of patients progression-free at two years and overall survival up to 89%. In solid tumors, we continue to see strong performance from ERLEADA and RYBREVANT. We shared important new data for both at ASCO that could change clinical practice. For ERLEADA, we opened the ASCO plenary with our phase III PROTEUS study, showing that treatment before and after surgery significantly reduces the risk of metastasis or death in high-risk localized prostate cancer. With RYBREVANT, we demonstrated durable responses in head and neck cancer, an area with limited options, and have submitted a filing to the FDA to build on existing lung cancer indications.

While we are not yet reporting quarterly sales for INLEXZO in bladder cancer, we are encouraged by the early momentum. During the second quarter, nearly one in three eligible patients started on an INLEXZO regimen, and new patient insertions grew approximately 75% versus prior quarter. Building on our recent acquisition of Halda Therapeutics, we also announced plans to acquire Firefly Bio, adding another antibody platform that strengthens our leadership in next-generation oncology innovation. We expect the transaction to close during the third quarter. In immunology, we have built one of the deepest and most differentiated portfolios in the industry. TREMFYA remains the fastest-growing advanced therapy in both Crohn's disease and ulcerative colitis, delivering exceptional overall sales growth of 71% in the quarter. With a dual powerhouse of TREMFYA and ICOTYDE in psoriasis, we now have a complementary portfolio of both first-line biologic and first-line systemic treatments.

We continue to see strong uptake of IMAAVY in generalized myasthenia gravis and recently received FDA priority review status in warm autoimmune hemolytic anemia. In neuroscience, we are developing treatments to transform care for complex brain and nervous system disorders. SPRAVATO and CAPLYTA both performed strongly in the quarter. CAPLYTA new patient starts were up 122% versus prior year, significantly outpacing the market leader. With FDA approval for the prevention of relapse in schizophrenia, we anticipate continued momentum. Now let's turn to MedTech, where we delivered Q2 operational sales growth of 3.6%. In cardiovascular, we are the global leaders in electrophysiology, circulatory restoration, and heart recovery. VARIPULSE, our pulsed field ablation platform for atrial fibrillation, continues to build momentum with more than 85,000 AFib patients now treated worldwide.

In Q2, our position was further strengthened with the debut of CARTOSOUND SONATA, bringing new AI-powered imaging and mapping capabilities to electrophysiology. We also received FDA authorization for our Dual-Energy THERMOCOOL SMARTTOUCH SF Platform, which integrates pulsed field and radiofrequency energy in a single system to give physicians greater flexibility in tailoring ablation treatments for patients. In circulatory restoration, the Q2 global launch of Shockwave C2 Aero expanded our ability to treat more complex coronary disease and broadens the reach of our intravascular lithotripsy platform. In heart recovery, while Abiomed growth slowed in Q2 as a result of increased physician selectivity weighing on procedural volumes, we are working to strengthen the confidence in our extensive clinical evidence and real-world experience. In surgery, we are unlocking a new era powered by robotics and digital innovation.

We are progressing towards potential FDA authorization of OTTAVA, the world's first table-integrated robotic surgical system. This is one of the most significant MedTech innovations we will bring to market this decade. OTTAVA's unique architecture, automated features, and next-generation robotic instruments help address surgeons and med needs, while integration with our Polyphonic open digital ecosystem provides data-driven insights and analytics to better support surgical teams. This quarter, we also received CE mark approval for the ETHICON 4000 Stapler, the latest advancement in our line of surgical technologies. In vision, we have a bold ambition to make vision possible for more than 40 million people each year. In Q2, we announced the expanded U.S. availability of TECNIS PureSee as we accelerate the rollout of this extended depth of focus intraocular lens. Our ACUVUE portfolio delivered strong quarterly growth across all regions.

As a part of our $55 billion U.S. commitment, we recently announced an investment of more than $1 billion to scale our U.S. Vision manufacturing, packaging, and distribution capabilities as we expand capacity to meet growing demand for these products. Our progress in Q2 reflects what makes Johnson & Johnson unique, a company innovating across the full spectrum of healthcare, delivering strong performance today while building a pipeline that will transform care for patients tomorrow. As we look ahead, our confidence is rooted in the breadth of our innovation, from transformational medicines to next-generation medical technologies. That combination of science, scale, and disciplined execution is what uniquely positions Johnson & Johnson to lead the next wave of healthcare innovation. I will now turn the call back over to Ryan.

Thank you, Joaquin. Moving to our financial results. Unless otherwise stated, the percentages quoted represent operational results and therefore exclude the impact of currency translation. Starting with Q2 2026 sales results. Worldwide sales were $25.3 billion for the quarter. Sales increased 5.6% despite an approximate 460 basis point headwind from STELARA. Excluding STELARA, Johnson & Johnson grew double digits for the quarter. Growth in the U.S. was 7.3% and 3.4% outside of the U.S. Acquisitions and divestitures had a net negative impact on worldwide growth of 10 basis points. Now turning to earnings. For the quarter, net earnings were $5.5 billion and diluted earnings per share were $2.27 versus $2.29 a year ago. Adjusted net earnings for the quarter were $7.1 billion and adjusted diluted earnings per share were $2.90, representing an increase of 5.7% and 4.7% respectively compared to the second quarter of 2025.

I will now comment on business sales results in the quarter, focusing on the six key areas where meaningful innovation and strong commercial execution are driving our performance and fueling long-term growth. Beginning with Innovative Medicine, where our financial results reflect the depth of our expertise and innovation in areas of high unmet need across oncology, immunology, and neuroscience. Worldwide sales of $16.4 billion increased 6.8%, despite an approximate 760 basis point headwind from STELARA, which underscores the continued strength of our key brands and new launches. Growth in the U.S. was 8.9% and 3.6% outside of the U.S. Divestitures had a negative impact of 10 basis points on worldwide growth. In oncology, starting with multiple myeloma, DARZALEX growth was 17.6%, primarily driven by strong share gains of five points across all lines of therapy with nearly 11 points in the frontline setting as well as continued market growth.

CARVYKTI achieved growth of 47.7%, driven by share gains and continued site expansion. TECVAYLI growth was 56.1%, with worldwide sequential growth of 29.2% and impressive U.S. sequential growth of 46.2%, driven by launch uptake and share gains across earlier lines of therapy following last quarter's approval in the U.S. for TECVAYLI plus DARZALEX FASPRO and from expansion in the community setting. TALVEY growth was 62.6%, driven by share gains due to increased depth of prescribing in the community setting. In lung cancer, RYBREVANT plus LAZCLUZE delivered growth of 61.6%, driven by continued launch uptake in all regions, share gains in the first and second lines with rapid uptake in RYBREVANT FASPRO. In prostate cancer, ERLEADA delivered growth of 7.6% with continued share gains and market growth, partially offset by unfavorable patient mix and inventory dynamics.

Within immunology, TREMFYA delivered impressive growth of 71% as the IBD launch is driving significant momentum and we continue to see share gains across all indications as well as continued market growth. STELARA declined 55.7%, driven by share loss due to biosimilar competition, increasing adoption of novel classes, and unfavorable patient mix. Growth in other immunology is driven by U.S. new product launches, IMAAVY and ICOTYDE. In neuroscience, SPRAVATO grew 40%, driven by continued strong demand from physicians and patients and strong sequential growth of 24.8%. CAPLYTA showed significant growth of 70.9%, driven by strong continued launch momentum in adjunctive major depressive disorder. Moving to MedTech, where we delivered growth across each of our key focus areas, cardiovascular, surgery, and vision. Worldwide sales of $8.9 billion increased 3.6% with growth of 3.9% in the U.S. and 3.2% outside the U.S.

Acquisitions and divestitures had a net negative impact of 10 basis points on worldwide growth. Overall, cardiovascular grew 3.1%, which is lower than our recent trend, primarily due to headwinds in electrophysiology and Abiomed. In electrophysiology, growth of 3.1% was driven by procedure growth, commercial execution, and new product performance, partially offset by competitive PFA pressures. There was also a negative impact from China inventory, which we estimate to be 400 basis points. Abiomed saw a decline of 2% due to pressures on U.S. procedures driven by usage patterns. The downturn came as physicians evaluated the results of a recent external clinical trial, which increased selectivity within the quarter, particularly in the U.S. The decline was partially offset by continued OUS growth, including sustained adoption of Impella 5.5. Shockwave grew double digits at 14.7%, driven by continued adoption of coronary and peripheral products, as well as new product launches.

Surgery grew 2.3%, including a negative impact of approximately 40 basis points from divestitures. Growth was driven by strength of the portfolio and commercial execution in biosurgery and wound closure, partially offset by VBP in China and surgery transformation across the portfolio, as well as competitive pressures in energy and endo cutters. Vision growth was 5.6%, driven by premium innovation, strong execution, and global reach. Contact lenses and other products had a strong quarter with 6% growth, driven by strong performance in the ACUVUE OASYS 1-Day family of products, further solidifying our leadership position. Surgical vision grew 4.7%, driven by new product innovations, robust demand for premium IOLs, and strong commercial execution, partially offset by competitive pressures in the U.S. Orthopedics growth for the quarter was 4.2%, primarily driven by new product launches such as VOLT in Trauma and strong commercial execution across the portfolio.

Turning to our consolidated statement of earnings for the second quarter of 2026. I'd like to highlight a few noteworthy items that have changed compared to the same quarter of last year. Cost of goods sold leveraged by 30 basis points, driven by favorable operational drivers and currency, partially offset by unfavorable product mix in the Innovative Medicine business, as well as the impact of tariffs in the MedTech business. Selling, marketing, and administrative expenses deleveraged by 60 basis points, driven by increased investments in our new product launches. Research & Development leveraged by 40 basis points, primarily driven by expense phasing in the Innovative Medicine business, partially offset by increased investment in MedTech. Interest income and expense was a net expense of $62 million, as compared to $48 million of expense in the second quarter of 2025.

Other income and expense was a net expense of $331 million, as compared to $107 million of expense in the second quarter of 2025, with the change primarily driven by higher litigation expense, restructuring-related asset impairments, and orthopedic separation-related costs, partially offset by higher gains on securities. For taxes on a GAAP basis, the effective rate in the second quarter of 2026 was 18%, compared to 14.7% in the second quarter of 2025. More information can be found in our upcoming 10-Q for changes in taxes. Lastly, I'll direct your attention to the box section of the slide where we also have provided our income before tax, net earnings, and earnings per share adjusted to exclude the impact of intangible amortization expense and special items. Let's look at adjusted income before tax by segment for the quarter.

Innovative Medicine margin declined from 42.7% to 42.5%, primarily driven by unfavorable mix and heavier investments in new product launches, partially offset by expense phasing in research and development. MedTech margin declined from 22.2% to 22%, primarily driven by commercial investments, increased research and development, and the increased impact of tariffs, partially offset by favorable operational drivers in currency and cost of products sold. As a result, adjusted income before tax for the enterprise as a percentage of sales decreased from 34.5% to 34.2%. This concludes the sales and earnings portion of the call. I will now turn the call over to Joe.

Thank you, Ryan. Congratulations on your first earnings call. Your experience across all parts of Johnson & Johnson's business will be a real asset to our company as well as the investment community. We're glad you're in the role. Hello, everyone. Thank you for joining us today. As Joaquin highlighted earlier, we delivered a solid quarter, supported by the depth of our in-market portfolio and strong execution across our new product launches, with particularly good growth in Innovative Medicine. In MedTech, results were not to our standards in cardiovascular, primarily heart recovery. However, we remain confident in our long-term projections for the MedTech business. A quarter like this, I believe, underscores the strength of Johnson & Johnson. Even with a notable headwind, we still delivered performance that exceeded your expectations and enabled us to confidently raise our full year 2026 financial outlook.

We are not dependent on one or two products. We have a broad, durable portfolio that has 28 platforms, each generating more than $1 billion in annual revenue that we are intent on adding to in the coming years. It is that foundation that gives us clear line of sight to double-digit growth by the end of the decade. Turning to results with our cash position. We ended the second quarter with approximately $21 billion of cash and marketable securities and approximately $49 billion of debt, for a net debt position of approximately $28 billion. You may recall in Q1 that free cash flow was light. As expected, we had significant improvement in the second quarter with year to date totaling approximately $8.7 billion and are on track for our full year free cash flow outlook approaching $21 billion. Our capital allocation priorities remain unchanged.

We continue to prioritize investments with a focus on supporting our commercial launches and advancing future innovation. As stated previously, acquisitions are an enabler of growth, but they are not a requirement to deliver on our near and long-term objectives. Our financial strength allows us to continue investing in R&D while pursuing opportunities where our scientific and commercial capabilities can accelerate innovation and create differentiated value. A good example of that is the recently announced agreement to acquire Firefly Bio. The planned acquisition, expected to close in the third quarter of 2026, will add a proprietary platform designed to target KRAS-driven solid tumors, which are typically more difficult to treat and further diversifies our oncology pipeline. We also remain committed to returning capital directly to shareholders, primarily through our dividend. Turning to full-year guidance for 2026.

As always, our outlook reflects what we know today regarding foreign exchange rates, tariffs, the broader macroeconomic environment, and other external factors. Driven by second quarter performance and uptake of new product launches, we are increasing operational sales growth by $400 million, now expecting operational sales growth for the full year to be in the range of 6.5%-7.1%, with a midpoint of $100.6 billion. As a reminder, our financial calendar in 2026 includes a 53rd week, which provides a benefit of approximately 100 basis points in 2026. We do not speculate on future currency movements. Last quarter, we utilized a euro spot rate to the U.S. dollar of 1.17. As of last week, the euro spot rate to the U.S. dollar was 1.14. Based on all major currency movements, we estimate a negative total foreign currency impact of $100 million versus prior guidance.

As a result, we now expect reported sales growth of 7.0%-7.6%, with a midpoint of $101.1 billion or 7.3%. As we look at the remainder of the year, based on year-to-date performance and updated guidance, we anticipate operational sales growth to improve in the second half of the year. As a reminder, fourth quarter growth should be higher due to the benefit from the 53rd week. Turning to other notable items on the P&L. At the beginning of the year, we guided to more than a 50 basis point improvement in adjusted pre-tax operating margin. We now expect approximately a 75 basis point improvement, supported by continuing operating efficiencies and anticipated reduction and recoupment of certain tariff-related costs based on the latest rulings.

This pre-tax operating margin improvement also considers the expected costs from the 53rd week of operations and the previously announced agreement with the U.S. government to improve access to medicines and lower costs to U.S. patients. For net interest expense, we now project $250 million-$300 million, slightly lower than previous guidance. Our effective tax rate is now expected to be lower in a range of 17.0%-18.0% for the full year based on year-to-date results. Turning to earnings per share. We are pleased to increase our adjusted operational earnings per share range to $11.50-$11.65, which equates to an increase of $0.18 at the midpoint. This represents a year-on-year adjusted operational EPS growth of 7.3%. Reported earnings per share is projected to be $11.60-$11.75, or $11.68 at the midpoint, which represents an 8.2% increase over the prior year.

The updated earnings per share guidance range includes a $0.05 reduction of favorable currency when compared to prior guidance. Our current outlook does not include the impact of any pending acquisitions such as Firefly Bio. We have several meaningful pipeline catalysts in the second half of the year. We anticipate FDA regulatory approval for IMAAVY as the first-ever treatment for patients with warm autoimmune hemolytic anemia, a rare and serious autoantibody disease. We also have important data readouts across our Innovative Medicine pipeline, including TECVAYLI in combination with TALVEY for patients with relapsed refractory multiple myeloma who have received one to four prior lines of therapy. Pasritamig, a first-in-class bispecific antibody in patients with advanced prostate cancer who have progressed after multiple lines of therapy. J&J-6143, an investigational first-in-class, once-daily oral therapy for metastatic castration-resistant prostate cancer.

This will be the first clinical readout from an ongoing study from our recent Halda acquisition. We are also expecting data readouts for INLEXZO in high-risk non-muscle invasive bladder cancer, ICOTYDE in psoriatic arthritis, and CAPLYTA in bipolar mania. Turning to MedTech, there are several important catalysts that we expect to generate momentum. In cardiovascular, we expect launches for the Dual Energy THERMOCOOL SMARTTOUCH SF Platform, as well as the Shockwave C2 Aero and Aero Fly IVL catheters. In electrophysiology, we expect continued adoption of CARTOSOUND SONATA cardio mapping in the U.S. and VARIPULSE Pro in EMEA, with anticipated approval of VARIPULSE Pro in the U.S. later this year. In surgery, we anticipate FDA approval for the OTTAVA robotic surgical system and the EMEA launch of ETHICON 4000.

In vision, we continue to expand availability of TECNIS PureSee intraocular lens for cataract and presbyopia while driving adoption of ACUVUE OASYS MAX lenses. Finally, the orthopedics business under Namal Nawana's leadership had another quarter of improvement. We continue to evaluate all separation options that create shareholder value and set the DePuy Synthes business up for success long term. We are pleased with the progress made, are on track for a mid-2027 separation, and look forward to sharing updates later this year. To wrap up before we take your questions, our first half performance illustrates the strength and resilience of our portfolio, the momentum we are building behind our new products, and the steady progress we are making across our pipeline. Strategic focus, scale, and financial flexibility to invest in opportunities we believe will create the greatest value for patients should translate into meaningful value for shareholders.

We look forward to sharing more on strategy, growth catalysts, and a longer-term outlook at our enterprise business review on December 8th. To our colleagues around the world, thank you. Your dedication and disciplined execution are what make our performance possible, and you continue to deliver meaningful innovation to more patients, improve outcomes, and raise the standard of care. With that, we are pleased to take your questions. Kevin, can you please open the call for Q&A?

Certainly. Ladies and gentlemen, if you'd like to ask a question at this time, please press star then one on your telephone keypad. If you'd like to withdraw your question, you can press star then two. Please limit your questions to one question only. Our first question is coming from Chris Schott from JPMorgan. Your line is now live.

Great. Thanks so much for the question. Congrats on all the progress. Maybe just, Joe, if you could dive a little bit more into the $400 million increase in operational sales guidance. I guess I was just looking for a little bit more color of the balance of pharma versus the MedTech components to this. I guess just bigger picture, is it fair to think about pharma moving higher here, maybe partially offset by a bit lower MedTech growth assumptions? Just any directional color there would be helpful. Thank you.

Yeah. Good morning, Chris. Thank you for the question. I would say that's probably a fair characterization. As you know, we always had a little bit better revenue growth projected in the second half of the year, irrespective of the extra week of sales that will occur in the fourth quarter. When you think about products that are really in their infancy with respect to ICOTYDE, INLEXZO, and just the emergence of TREMFYA continuing to do well with the IBD indications that were received over the last 18 months, there was always that projection. I think really maybe to the heart of your question is, we do expect MedTech to grow better in the second half than the first half as well. We have tempered expectations around the Abiomed business with respect to that.

We see that recovery happening, but probably as we leave this year into next year. Not declines, but more modest growth until our PROTECT IV data comes out, which I'm sure Tim will have an answer to in a future question to expand upon. Hopefully that helps, Chris.

Thank you. Our next question today is coming from Asad Haider from Goldman Sachs. Your line is now live.

Great. Thanks for taking the question. Maybe for Jennifer or John on ICOTYDE. The launch seems to be progressing well. You noted 10,000 patients have now initiated therapy. Just wondering if you can provide any update on prescriber count relative to the last update of 4,500 prescribers that you called out in June. What can you tell us about sampling and free drugs that you're providing and where you are with formulary negotiations? When can we expect to see you break out sales? Then maybe just a second part on that, how are you positioning TREMFYA and ICOTYDE together to the dermatologist community in psoriasis? Are there any synergies or advantages that you're seeing emerge from having both options? Thank you.

Great. Well, thanks, Asad. This is Jennifer. Good morning, everybody. I really want to start with a big thank you to all of our Innovative Medicine colleagues around the world for an outstanding quarter of delivering for patients. Over $16 billion in sales, our first $16 billion quarter. 6.8% operational growth. It's also worth noting, STELARA was only 4% of our Innovative Medicine business in the second quarter. If you exclude that, the 96% of our business, 96%, actually grew over 14%. This really based on the strong growth across our main key brands as well as our must-win launches. The team has really done an outstanding job around the world on that. Glad to have the opportunity to talk about ICOTYDE because we are really thrilled with the launch and how it's progressing.

I think as we noted last time, we feel really good about the differentiated label that we got. ICOTYDE is the first and only targeted oral peptide that precisely blocks the IL-23 inhibitor. We talk about the U.S. launch and get into some of the details that you asked, it's really off to a strong start. As a reminder, we were ready day one, and in fact, the first patient prescribed received ICOTYDE on that launch day, and early physician and patient enthusiasm has been really great. We get into numbers on it, to date, over 18,000 prescriptions have been written for a total of now 11,000 patients. That's an update from the 10,000 just shortly. There are 6,000 unique prescribers, and if you take a look at those, over 50% are actually advanced practice providers.

About 40% are dermatologists, and the rest are our primary care physicians and others. That tells us that there's really good confidence in the product, in both the efficacy and safety profile, as well as the simplicity of the simple once-daily pill. We're already seeing a number of writers who are repeat. We're seeing patients getting repeat prescriptions. As we take a look at the payer coverage, within 90 days, we already have over 50% of commercial coverage, we think that's great. That's actually a little bit ahead of our projections. Teams making really great progress on the payer coverage there. In total, we think the launch is going very well. You asked about ICOTYDE and TREMFYA, and I think really, really important to note, we've got this great uptick in ICOTYDE. This has not slowed down TREMFYA in psoriatic disease at all.

TREMFYA in psoriatic disease, psoriasis, and PSA, that growth and market share gains has actually continued well above the market and notable in the second quarter that we got approval for inhibition of structural damage for TREMFYA in psoria and PSA. In terms of really co-positioning, ICOTYDE is the first-choice systemic treatment. All those patients who've been cycling on topicals who really need to have advanced therapy, we think ICOTYDE fits right in that sweet spot as that first-choice systemic. For TREMFYA, we think it's the first-choice biologic, particularly for patients that have potential for or have any psoriatic arthritis involvement, and many, many patients, a significant percentage with psoriasis actually progress to psoriatic arthritis as well. We think really distinct and unique positions for both, and well reflected in the results that we saw in the quarter with both products doing really well.

Additionally, we are investing to win on ICOTYDE. This is one of our must-win launches. In addition to what you've seen, we actually also started our direct-to-consumer advertising yesterday. Those of you who are watching World Cup or baseball had a chance to see that. We think this is even going to further bring more patients in to talk to their providers about new options for psoriasis.

Maybe one quick addition, John Reed here. We do expect to have pivotal data later this year for ICOTYDE in psoriatic arthritis, and as Jennifer pointed out, there's overlap in the psoriasis and psoriatic arthritis populations as psoriasis, the skin manifestations are often a comorbidity for patients with psoriatic arthritis. Our phase III studies in ulcerative colitis and Crohn's are in full steam now, we're moving ICOTYDE forward as a possible frontline therapy there as well.

Thank you. Our next question is coming from Larry Biegelsen from Wells Fargo. Your line is now live.

Good morning. Thanks for taking the question. Tim, I'm sure you know there continue to be concerns about procedure growth in the U.S. What did you see in Q2, and how are you thinking about procedure growth the rest of the year? Regarding J&J, I heard Joe say the second half J&J MedTech growth would be better than the first half, which was 4.2%, I believe. Do you still expect MedTech to grow faster in 2026, excluding the extra week? Thank you.

Larry, thank you so much for the question. Let me, before I get into procedure volume, and certainly given the news we've heard from hospital providers this week, I know it's a hot topic, but I'd like to put really our second quarter performance in context for you and for others. When we step back and we look across the full portfolio, the underlying picture remains solid. Procedure volumes continue to be stable, and we're not seeing evidence of a broad-based slowdown in demand. To be clear, Larry, three of our four businesses, surgery, vision, and orthopedics, all accelerated in the quarter and performed above expectations. Surgery growth was driven by continued strong performance in wound closure and almost double-digit growth in biosurgery. Vision, you would've noticed, delivered meaningful acceleration in contact lens and continued momentum in IOLs.

In orthopedics, as you heard already from Joe, we continue to see that business go from strength to strength, reflecting stronger execution and the impact of multiple new products. I would like to turn quickly to CV, and let me first acknowledge that our Q2 growth is not where you wanted it, and frankly, it's not where we wanted it. That said, we know what happened, and we know exactly what we're doing about it. In full transparency, CV growth was more muted this quarter in both EP and heart recovery, partially offset by continued double-digit growth in Shockwave. In EP, as you already heard, we continue to see strong underlying demand. However, we did have an inventory dynamic in China, which impacted our growth by about 400 basis points that would've taken global growth up to north of 7%.

In heart recovery, due to a recent neutral clinical trial in the U.K., Impella usage has slowed. We see this as a near-term dynamic, and we're actively engaging physicians and their teams to reinforce appropriate patient selection, leveraging the significant depth of our clinical evidence base. Again, to put it all in context, three out of our four businesses performed well, and we're confidently addressing the fourth, and nothing we see changes our conviction in the long-term growth thesis for both our CV business as well as J&J MedTech at large. To your question about procedure volumes. From our perspective, when we look across the breadth of our portfolio, we see that volumes are generally in line with market trends, and we're not currently seeing any evidence of a broad-based slowdown in activity.

Demand remains consistent with what we would expect given the fundamentals of these markets, which, as you know, continue to be driven by themes such as aging populations, increasing disease prevalence, and ongoing innovation that is expanding our access to more patients. We are acutely aware of the recent data that has been provided by a number of large U.S. hospital operators, highlighting pressure on certain procedure volumes, particularly in more elective areas of care. While we're monitoring these trends very closely, they are not reflected in what we're seeing across our portfolio today. As you know, our business is diversified across a broad range of categories, many of which are less dependent on discretionary elective procedures. From our perspective, overall procedure trends remain consistent in the quarter with our expectations.

I will also point to, there has been a bunch of chatter about the potential impact of the ACA subsidy removals. Based on what we're seeing, we haven't observed any meaningful impact on procedure volumes across our portfolio related to the ACA. While we expect that the expiration of the Affordable Care Act subsidies may create some affordability pressures for a small cohort of patients, we do not expect this to translate into a material impact on demand for MedTech and procedures. To be clear, we would not attribute our MedTech performance in Q2 to a systemic slowdown in procedures.

As already mentioned, we do expect acceleration of our performance in the second half, driven by continued performance of our businesses in Vision, in Orthopedics, and in Surgery, and certainly improvement on the back of our efforts to drive greater performance within Cardiovascular. Thanks, Larry, and looking forward to seeing you next week at SRS.

Thank you. Our next question today is coming from Terence Flynn from Morgan Stanley. Your line is now live.

Great. Thanks so much for taking the questions. Congrats on the quarter. I was just wondering, Jennifer, if you could expand on what you are seeing with TECVAYLI. Obviously, some important new data that has been added to the label recently. Just wondering how that is impacting the growth dynamics, and then maybe you could expand on what you are seeing in terms of academic versus community use. Thank you.

Good morning, Terence. We had a great quarter for TECVAYLI, with sales of $260 million, up 56% versus prior year. That was driven by significant launch uptake and share gains across the earlier lines of therapy based on the approval that we got in the U.S. for TECVAYLI plus DARZALEX, and also continued expansion in the community setting. We are real excited about the approval of the combination regimen there. It is the first and only steroid-free, readily available, immediate immunotherapy option that really has that best-in-class efficacy and the potential for cure for patients in that second-line setting. As a reminder on that data, because we think it is truly extraordinary, at three years, 83% of patients remained alive and progression-free. This is really resonating with physicians.

In terms of U.S. uptake, we are seeing really strong early U.S. demand following the rapid approval that we had for TECVAYLI plus DARZALEX. If you take a look quarter-to-quarter, like first quarter to second quarter, we saw a 29% increase in sequential growth there. That is in terms of patients that were initiated in TECVAYLI, and this is really due to new account adoption and increasing depth of prescribing. Furthermore, the vast majority of patients now with TECVAYLI plus DARZALEX are starting in that second to third-line setting, and we continue to see increases in community site really set up an expansion in the U.S. They had a 25% quarter-over-quarter increase in community sites expansion there. We are feeling really good about what we are seeing in terms of TECVAYLI and TECVAYLI growth along with DARZALEX in that second and third-line setting.

Thank you. Our next question today is coming from Joanne Wuensch from Citibank. Your line is now live.

Good morning, and thank you for taking the question. You have a fairly robust robotics portfolio that should be rolling out over the next couple of quarters. You did mention SRS. Could you please sort of give us an update of the lay of the land and what we might expect next week? Thank you.

Joanne, thank you for the question and certainly your interest in our robotics program. As you know, we have been worldwide leaders in open and laparoscopic surgery. Certainly we are excited and very much committed to being a major player in the area of surgical robotics. I think you know that we are eagerly awaiting approval of OTTAVA, which we submitted late last year. We are actively working on our second clinical trial, specifically focused on inguinal hernia. We will provide much more detail around our exciting launch plans once approvals have been secured. That said, we are committed to the launch of two, assuming approvals come our way, which we're very confident about.

We are committed to two large robotic launches this year, both the launch of OTTAVA, which we believe is truly differentiated against the existing incumbent, and of course, the launch of MONARCH for Urology, which will be a first of kind opportunity in that particular area. We will provide more information about those two launches, some more information next week. We'll also provide some updates certainly on the FORTE trial, which was our clinical trial, which was actually presented at the ASMBS conference about a month and a half ago. I actually had the opportunity to attend a meeting out in California with about 70 world-renowned robotic surgeons and got to see firsthand our surgeons not only listen to the specialists about the trial but also to actually drive the robot.

Frankly, just seeing the looks on their faces, the feedback we received gives me even more confidence that we have a device that will absolutely compete against the current incumbent. More to come on that. Thank you again, Joanne.

To be clear, Joanne, this is Joaquin. We see our robotics platform, both OTTAVA and MONARCH, being a meaningful contributor to MedTech growth by the end of the decade.

Thank you. Our next question today is coming from Vamil Divan from Guggenheim Securities. Your line is now live.

Great. Thanks for taking my question. Maybe following up on similar to the other question on ICOTYDE, I was hoping to get a little more color on INLEXZO and the progress you're making there. I know you said sort of one in three eligible patients now receiving it, and inflation's up, I think you said 75%. Maybe you can just give a little more color on where you're seeing utilization to differentiate between the community setting, academic setting, what sorts of patients are getting the products? I do not know if you can share anything around patient numbers or prescriber numbers. The other part was just around, you have the SunRISe-5 data coming out, you said later this year. Maybe you can just set expectations on what you're hoping to see from that data. Thank you.

Great. Good morning. Thanks for the question on INLEXZO. As a reminder, bladder cancer is the sixth most common type of cancer. There's over 600,000 new patients that are diagnosed globally each year and another 400,000 that are recurrent, so for a total of 1 million patients. This really helps us have great confidence this is an extraordinary opportunity for us with INLEXZO and then ultimately with our erdafitinib device as well. The launch of INLEXZO is going really well in the U.S. We have got the J-code now, I think that's probably what you're interested in hearing how it's going post J-code. In the U.S., INLEXZO is outperforming all of the recent competitive launches. As you noted, one in three eligible patients are now starting on an INLEXZO regimen.

This is an uptick versus first quarter, where it was one in four last quarter. It's now one in three, and it's leading all of the novel agents in terms of new patient share. In terms of new patients and new patient insertions, those grew 75% quarter-over-quarter, and this was post the permanent J-code, giving a lot of confidence to providers in terms of that reimbursement. Importantly, INLEXZO is included in the NCCN guidelines with a Category 2A designation, and they've been updated to expand the opportunity to include the papillary population, which represents about 80% of the BCG unresponsive patients. While we don't report sales on this yet, please know that we confidently beat consensus for the quarter, and we more than doubled sales in second quarter versus first quarter. We believe that we're really on a very good track with this.

You mentioned I'll turn it to John in a second. We do have our SunRISe program right now. INLEXZO is based on the SunRISe-1 population in BCG unresponsive patients. That's about 3,000 patients in the U.S. SunRISe-5 is the BCG experienced patients, largely high-risk papillary. That's about 10,000-15,000 patients. The biggest opportunity is the SunRISe-3 population. That's the BCG naive. That's about 40,000-50,000 patients in the U.S. That's our program, and that's before we even get to the erdafitinib piece. John.

I think Jennifer covered the SunRISe program well. Recognize that the approval in this so-called CIS or carcinoma in situ population, that's only about 5% of the eligible population. We really see a lot of growth potential ahead as we round out to the papillary cancers and then move from the second-line BCG experienced into the front line with our ambitious head-to-head program. I would just remind again that INLEXZO delivered the highest complete response rates that had ever been seen in this population, this second-line BCG non-responsive population with high-risk muscle, non-muscle invasive bladder cancer. Really a lot of excitement around it. Right on the heels of that is coming our erdafitinib, a targeted therapy in a novel device that offers not three weeks like INLEXZO, but three months of sustained delivery of the medicine.

That's being positioned for the intermediate risk non-muscle invasive bladder cancer, which is a very large population and is targeted at the FGF receptor mutant cancers, which is the most common genetic lesion in bladder cancer. Really excited about where the portfolio's going in the near term. Beyond that, we expect to have other payloads and other devices that will continue to elevate the standard of care for patients struggling with bladder cancer to keep their bladder. Very excited for that million patients a year that are diagnosed with non-muscle invasive bladder cancer.

Thank you. Our next question today is coming from Alex Hammond from Wolfe Research. Your line is now live.

Thanks for taking the question. A few on milvexian. Can you remind us of your confidence level in AFib? I guess given the size and breadth of the milvexian program, it seems like there's potentially a wide set of outcomes between a clean win and miss. Is the trial still on track for later this year? I did not see it on the slide deck. Thank you.

Okay. Sorry, I misunderstood part of the question. On milvexian, these are event-driven studies. They're fully recruited. We really can't give you very much insight into when they might read out. Could be towards the end of this year, beginning of next year, but because they're event driven, we'll just have to wait for the events. We remain confident that for the atrial fibrillation indication, which is the largest of those opportunities, that we have the right dose and schedule based on the careful work done in phase II, based on the biomarker we're following, the TPP, that gives us confidence that we've achieved a healthy level of anticoagulation. Our data monitoring committee continues to look at the data.

They keep saying, "Go full steam ahead." We're cautiously optimistic but are waiting for the endpoints to the events to occur so that we can read out the full study results.

Alex, we're really excited about the milvexian opportunity. We think there is significant opportunity in the market for a product that's got the better bleeding profile than the current anticoagulants that are out there today. Maybe as a reminder, about 40% of AFib patients who are eligible are currently not receiving oral anticoagulants as they should or at the right level because there's concerns about potential bleeding. We think that a product that represents the potential of the milvexian profile, what we're hoping to demonstrate really could be a game changer for patients and significant opportunity in the market. We're really excited to see the results of the study when they come. As John noted, it's event-driven study, we're going to have to wait and see what they are. Once we know, you guys will know too, right?

Yeah. Maybe just building quick on that. It's estimated that there are eight million people in this country alone who are taking an oral anticoagulant, but it's thought that there may be as many as 18 million who should be taking one, but because of the bleeding risk of the current agents are unable. We're really excited about the possibility to offer this, both the efficacy along with the safety profile that milvexian promises.

Johnson & Johnson (JNJ) Q2 2026 Earnings Call Transcript

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