• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia
NewslettersTerm Sheet

Term Sheet Next: How a16z crypto’s Arianna Simpson has navigated the blockchain rollercoaster

By
Leo Schwartz
Leo Schwartz
Former Senior Writer
Down Arrow Button Icon
By
Leo Schwartz
Leo Schwartz
Former Senior Writer
Down Arrow Button Icon
September 8, 2025, 7:02 AM ET
Arianna Simpson, general partner at Andreessen Horowitz.
Arianna Simpson, general partner at Andreessen Horowitz.Nathan Laine—Getty Images
Add Fortune on Google for similar content.

When Arianna Simpson was 22 years old, she plowed her savings into Bitcoin. She had left her college job and traveled with a friend through Zimbabwe, witnessing firsthand the consequences of hyperinflation. When she returned, she became enamored with the idea of crypto as a potential salve. 

Recommended Video

Aside from investing the contents of her bank account, Simpson started a blockchain lunch meetup at her next post, Facebook. She wrote a blog post on multisignature wallets that landed her a job at the infrastructure startup BitGo, where she became the third employee. (More than 10 years later, BitGo is set to go public, though Simpson sadly left before her shares vested.) 

Instead of sticking it out in the early crypto startup trenches, Simpson moved into venture, first working at a friend’s generalist firm before starting her own crypto fund, Autonomous Partners, which raised from Brian Armstrong, David Sacks’ Craft Ventures, and Steve Cohen’s family office. This was 2017, when crypto was beginning to explode into the mainstream, and Simpson invested in companies like Talos and Mythical Games. Through Armstrong, she also met Katie Haun, a Department of Justice prosecutor-turned-a16z investor, who convinced Simpson to come on board. 

Simpson joined a16z crypto as a deal partner in 2020. She liked that the firm had stayed in blockchain during the quiet times, which isn’t the case for many of the larger venture operations (even today, blue-chip names like Accel and Bessemer have mostly stayed away since the 2022 collapse). “I had a lot of respect and appreciation for the fact that the firm, despite being like an institution, had taken this category seriously,” Simpson says. 

It turned out to be a prudent decision. Simpson came on right at the start of the boom years, which included a16z crypto’s landmark $2.2 billion third fund in 2021 and $4.5 billion fourth fund in 2022. And amid power players like Chris Dixon and Haun, she made a name for herself investing early in companies like Blackbird, the dining rewards startup created by Resy cofounder Ben Leventhal, and Phantom, the crypto wallet recently valued at $3 billion. 

Now a general partner, Simpson’s approach has been to target founders, rather than just thematic areas, understanding that the best builders will be drawn to the most promising technology at the moment, whether it’s stablecoins or the intersection of crypto and AI. “It’s more about following the trends of entrepreneurs than it is unilaterally trying to decide what’s interesting,” she says. “As an investor, your job is to shift your attention to find it.”

See you tomorrow,

Leo Schwartz
X:
@leomschwartz
Email: leo.schwartz@fortune.com

Submit a deal for the Term Sheet newsletter here.

Joey Abrams curated the deals section of today’s newsletter. Subscribe here.

VENTURE DEALS

- Shift5, a Rosslyn, Va.-based operational intelligence company designed for defense and transportation systems, raised $75 million in Series C funding. Hedosophia led the round and was joined by Insight Partners, Center 15 Capital, 645 Ventures, Moore Strategic Ventures, Booz Allen Ventures, and others.

- Euclid Power, a New York City-based operating system for renewable energy project operations, raised $20 million in Series A funding. Venrock led the round and was joined by HSBC Asset Management, Spero Ventures, Toba Capital, Designer Fund, and Commonweal Ventures.

- Isotopes.AI, a Palo Alto, Calif.-based agentic AI company, raised $20 million in seed funding from NTTVC.

- Tobe Energy, a Oklahoma City, Okla.-based green hydrogen company, raised $1.8 million in seed funding. Cortado Ventures led the round and was joined by 46 VC, Techstars, and others.

PRIVATE EQUITY

- UltraViolet Cyber, backed by Achieve Partners, acquired the Application Security Testing business of Black Duck Services, a Burlington, Mass.-based application security platform. Financial terms were not disclosed.

EXITS

- Vision agreed to acquire Marcolin, a Longarone, Italy-based eyewear company, from PAI Partners. Financial terms were not disclosed.

FUNDS + FUNDS OF FUNDS

- Platinum Equity, a Los Angeles, Calif.-based private equity fund, raised $2.28 billion for its second small cap fund focused on the lower middle market companies.

PEOPLE

- Invidia Capital Management, a New York City-based private equity firm, hired Shaunak Parikh as a partner. He was formerly with EW Healthcare Partners.

This is the web version of Term Sheet, a daily newsletter on the biggest deals and dealmakers in venture capital and private equity. Sign up for free.
About the Author
By Leo SchwartzFormer Senior Writer
LinkedIn iconTwitter icon

Leo Schwartz is a former Fortune senior writer. He covered fintech, crypto, venture capital, and financial regulation.

See full bioRight Arrow Button Icon
Add Fortune on Google for similar content.

Latest in Newsletters

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025

Most Popular

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Fortune Secondary Logo
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • World's Most Admired Companies
  • See All Rankings
  • Lists Calendar
Sections
  • Finance
  • Fortune Crypto
  • Features
  • Leadership
  • Health
  • Commentary
  • Success
  • Retail
  • Mpw
  • Tech
  • Lifestyle
  • CEO Initiative
  • Asia
  • Politics
  • Conferences
  • Europe
  • Newsletters
  • Personal Finance
  • Environment
  • Magazine
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
  • Group Subscriptions
About Us
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • Facebook icon
  • Twitter icon
  • LinkedIn icon
  • Instagram icon
  • Pinterest icon

Latest in Newsletters

Brinker’s CIO spent years rebuilding restaurant tech. Now, the Chili’s operator is ready to explore more AI
NewslettersCIO Intelligence
Brinker’s CIO spent years rebuilding restaurant tech. Now, the Chili’s operator is ready to explore more AI
By John KellJune 17, 2026
17 hours ago
The Professional Women’s Hockey League is ready for its breakout moment
NewslettersMPW Daily
The Professional Women’s Hockey League is ready for its breakout moment
By Emma HinchliffeJune 17, 2026
19 hours ago
An executive team together in a conference meeting room in contemporary modern office.
NewslettersCFO Daily
CFO pay surged 8% last year—and long-term incentives now account for 63% of the average package
By Sheryl EstradaJune 17, 2026
22 hours ago
OpenAI’s balance sheet remains the most mysterious—and consequential—in business
NewslettersTerm Sheet
OpenAI’s balance sheet remains the most mysterious—and consequential—in business
By Allie GarfinkleJune 17, 2026
23 hours ago
TIAA CEO Thasunda Brown Duckett is undertaking a retirement revolution—with $1.5 trillion to back it up
NewslettersCEO Daily
TIAA CEO Thasunda Brown Duckett is undertaking a retirement revolution—with $1.5 trillion to back it up
By Alyson ShontellJune 17, 2026
1 day ago
Cursor co-founder and CEO Michael Truell speaking at Fortune Brainstorm AI 2025 in San Francisco, California. (Photo: Stuart Isett/Fortune)
NewslettersFortune Tech
SpaceX will officially acquire Cursor for $60 billion
By Andrew NuscaJune 17, 2026
1 day ago

Most Popular

Current price of oil as of June 17, 2026
Personal Finance
Current price of oil as of June 17, 2026
By Joseph HostetlerJune 17, 2026
21 hours ago
'Work hard, stay loyal, and the system will reward you': the Boomer credo is a Gen X betrayal and a Millennial pipe dream
Success
'Work hard, stay loyal, and the system will reward you': the Boomer credo is a Gen X betrayal and a Millennial pipe dream
By Nick LichtenbergJune 16, 2026
2 days ago
Hundreds of Stanford students walked out of their grad ceremony to protest Google CEO’s commencement speech. It wasn’t all about AI
Big Tech
Hundreds of Stanford students walked out of their grad ceremony to protest Google CEO’s commencement speech. It wasn’t all about AI
By Tristan BoveJune 15, 2026
3 days ago
Exclusive: Universal beat Disney as Hollywood's maker of the most expensive movie of all time 
Arts & Entertainment
Exclusive: Universal beat Disney as Hollywood's maker of the most expensive movie of all time 
By Christian SyltJune 17, 2026
23 hours ago
The affordability crisis is so bad that, for the first time ever, both mom and dad are working full-time in most American families
Economy
The affordability crisis is so bad that, for the first time ever, both mom and dad are working full-time in most American families
By Jacqueline MunisJune 17, 2026
13 hours ago
Current price of silver as of Wednesday, June 17, 2026
Personal Finance
Current price of silver as of Wednesday, June 17, 2026
By Joseph HostetlerJune 17, 2026
21 hours ago

© 2026 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.