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Pope Leo wades into business regulation, preaching the idea of an ethical AI framework to tech executives

Marco Quiroz-Gutierrez
By
Marco Quiroz-Gutierrez
Marco Quiroz-Gutierrez
Reporter
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Marco Quiroz-Gutierrez
By
Marco Quiroz-Gutierrez
Marco Quiroz-Gutierrez
Reporter
Down Arrow Button Icon
June 20, 2025, 2:57 PM ET
Pope Leo XIV has made advocating for ethical AI a priority of his papacy.
Pope Leo XIV has made advocating for ethical AI a priority of his papacy.Stefano Costantino—SOPA Images/LightRocket/Getty Images
  • Pope Leo XIV sent a letter to Vatican officials and tech leaders at the Holy See’s conference on AI this week. Leo has made AI a priority of his papacy and has advocated for an “ethical framework” for the governance of AI. 

Despite the Vatican’s lack of regulatory power, Pope Leo XIV is increasingly advocating for ethical AI oversight on the part of governments and companies, just a month into his papacy.

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The pontiff, who was elected in May following the death of Pope Francis, sent a message dated Tuesday to Silicon Valley executives and Vatican officials on Friday at the Holy See’s second annual conference on AI, ethics, and corporate governance held at the Apostolic Palace in Vatican City.

In his message, published by the Vatican, Leo said AI technology is a great tool but also could be misused and cause harm, especially to developmentally vulnerable children and young people. AI must take into account the uniqueness of the human person in order to operate ethically, he added.

“AI, especially generative AI, has opened new horizons on many different levels, including enhancing research in health care and scientific discovery, but also raises troubling questions on its possible repercussions on humanity’s openness to truth and beauty, on our distinctive ability to grasp and process reality,” he said.

Although the Vatican doesn’t have explicit regulatory power, Sacred Heart University Catholic studies professor Daniel Rober said the Holy See often lobbies foreign governments to advance its agenda.

By making ethical AI regulation a priority, Leo is also sending a message to individual Catholics and Catholic business leaders to take the idea seriously. 

“Acknowledging and respecting what is uniquely characteristic of the human person is essential to the discussion of any adequate ethical framework for the governance of AI,” Leo said in the message.

Leo has made ethical AI a priority of his papacy, mentioning it just two days after he became pope in his inaugural address to the College of Cardinals. He is building on the legacy of Pope Francis, who during his time as pontiff established the conference on AI held at the Vatican this week.

Leo is also following in the footsteps of his namesake, Leo XIII, who advocated for better working conditions during a period of rapid industrialization in the late 19th century and early 20th century.

“He took the name because he wants to be somebody who is commenting on the way in which technology, both AI and other things, are changing society, and wanting the church to be a voice advocating for humanity and for the human good in those circumstances,” Rober told Fortune.

While Leo advocates for ethical AI—and could be preparing to write a future encyclical (or formal letter to all Catholic bishops) on the subject, according to Rober—the debate on how much to regulate AI rages on worldwide. 

In the U.S., the absence of federal AI regulation has opened the door to state laws concerning AI, including on intellectual property rights and AI transparency. Still, the Trump administration’s budget bill passed by the House of Representatives in May includes a 10-year moratorium on the enforcement of state and local AI regulation, which threatens the patchwork of laws passed up to now.

Fortune Brainstorm AI returns to San Francisco Dec. 8–9 to convene the smartest people we know—technologists, entrepreneurs, Fortune Global 500 executives, investors, policymakers, and the brilliant minds in between—to explore and interrogate the most pressing questions about AI at another pivotal moment. Register here.
About the Author
Marco Quiroz-Gutierrez
By Marco Quiroz-GutierrezReporter
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Role: Reporter
Marco Quiroz-Gutierrez is a reporter for Fortune covering general business news.

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