• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia

Trendingnow

1

Pentagon accuses Alibaba, Baidu and BYD, three of China's biggest companies, of supporting the Chinese military

2

'We are rapidly running out of time': Watchdog sounds Social Security alarm after 22% cut confirmed for 2032

3

Costco CEO Ron Vachris rose from forklift driver to the C-suite without a college degree: ‘Don’t chase a title’ is the career advice that got him there

1

Pentagon accuses Alibaba, Baidu and BYD, three of China's biggest companies, of supporting the Chinese military

2

'We are rapidly running out of time': Watchdog sounds Social Security alarm after 22% cut confirmed for 2032

3

Costco CEO Ron Vachris rose from forklift driver to the C-suite without a college degree: ‘Don’t chase a title’ is the career advice that got him there
FinanceFortune 500

Apple was the most profitable company on the Fortune 500 list this year. These are the biggest profit generators, and what that means about American business.

Will Daniel
By
Will Daniel
Will Daniel
Down Arrow Button Icon
Will Daniel
By
Will Daniel
Will Daniel
Down Arrow Button Icon
May 24, 2022, 2:05 PM ET

American companies had a huge year in 2021. 

Together, the corporations on this year’s Fortune 500 list generated a record $1.8 trillion in profits on $16.1 trillion in revenue. 

The story of the top 10 most profitable U.S. companies reveals some major trends in the current American business landscape: Tech continues to dominate, energy companies remain in a secular decline despite a rebound in 2021, and a strong economy lifts all boats. 

Tech remains dominant

Apple once again took the top spot on Fortune’s list of the most profitable American companies in 2021. The tech giant raked in $94.7 billion in profits last year on revenues of $365.8 billion.

In the past, oil producers and even car companies like Ford were common sights at the top of the most profitable companies list, but these days, tech companies reign supreme. Tech giants represented three out of the top five most profitable companies in the U.S. in 2021 and half of the top 10.

Apple has also taken the top spot on the Fortune 500 most profitable list for seven out of the last eight years, only being eclipsed once by Warren Buffet’s Berkshire Hathaway in 2019.

Other tech profit generators in the top ten included Meta Platforms, Amazon, Microsoft, and Google’s parent company Alphabet.

Fossil fuel’s secular decline continues

The waning dominance of fossil fuel companies has been an ongoing trend over the past decade, and only one company, Exxon Mobil, nabbed a top spot in the most profitable list. 

But that doesn’t tell the whole story. 

Rising oil and gas prices lifted many energy companies to new heights in 2021, increasing the sector’s presence in this year’s Fortune 500. 

Still, from 2000 to 2015, Exxon Mobil earned the top spot as the most profitable U.S. firm 12 times, while this year it only managed the number nine slot. It was also the only company that didn’t post a double-digit year-over-year increase in profits compared to 2020.

A strong economy lifts banks, mortgage lenders

A strong economy and a record year for stocks meant big business for America’s banks and investment managers in 2021. 

U.S. banks pulled in $279.1 billion in profits last year, a $132 billion jump compared with 2020, FDIC data shows. Both JP Morgan Chase and Bank of America made it on this year’s top 10 most profitable U.S. firms list, while Citigroup, Goldman Sachs, and Wells Fargo came in at the 13th, 14th, and 15th spots, respectively.

Low-interest rates and a strong housing market in 2021 also pushed the Federal National Mortgage Association, a.k.a Fannie Mae, into the list of most profitable firms. The mortgage lender nearly doubled its profits compared to 2020 as the red-hot housing market raged, but with the market showing signs of a slowdown as mortgage rates rise, 2022 may be a different story.

Finally, Warren Buffet’s Berkshire Hathaway saw a record year in 2021, bolstered by rising stock prices in two of its largest holdings, Apple and Bank of America. Increasing profits in the conglomerate’s railroad, utilities and energy businesses and a turnaround in its insurance-underwriting operations also helped boost results.

Here’s a look at the top 10 most profitable firms in the U.S.

Apple

Revenue: $365.8 billion

Profit: $94.7 billion

Year-over-year change in profit: 64.9%

Berkshire Hathaway

Revenue: $276.1 billion

Profit: $89.8 billion

Year-over-year change in profit: 111.2%

Alphabet

Revenue: $257.6 billion

Profit: $76 billion

Year-over-year change in profit: 88.8%

Microsoft

Revenue: $168.1 billion

Profit: $61.3 billion

Year-over-year change in profit: 38.4%

JP Morgan Chase

Revenue: $127.2 billion

Profit: $48.3 billion

Year-over-year change in profit: 65.9%

Meta Platforms

Revenue: $117.9 billion

Profit: $39.4 billion

Year-over-year change in profit: 35.1%

Amazon

Revenue: $469.8

Profit: $33.4 billion

Year-over-year change in profit: 56.4%

Bank of America

Revenue: $93.8 billion

Profit: $32 billion

Year-over-year change in profit: 78.7%

Exxon Mobil

Revenue: $285.6 billion

Profit: $23 billion

Year-over-year change in profit: 0%

Fannie Mae

Revenue: $101.5 billion

Profit: $22.2 billion

Year-over-year change in profit: 87.9%

Sign up for the Fortune Features email list so you don’t miss our biggest features, exclusive interviews, and investigations.

About the Author
Will Daniel
By Will Daniel
LinkedIn iconTwitter icon
See full bioRight Arrow Button Icon

Latest in Finance

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025

Most Popular

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Fortune Secondary Logo
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • World's Most Admired Companies
  • See All Rankings
  • Lists Calendar
Sections
  • Finance
  • Fortune Crypto
  • Features
  • Leadership
  • Health
  • Commentary
  • Success
  • Retail
  • Mpw
  • Tech
  • Lifestyle
  • CEO Initiative
  • Asia
  • Politics
  • Conferences
  • Europe
  • Newsletters
  • Personal Finance
  • Environment
  • Magazine
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
  • Group Subscriptions
About Us
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • Facebook icon
  • Twitter icon
  • LinkedIn icon
  • Instagram icon
  • Pinterest icon

Latest in Finance

‘I love the inflation’: Trump is ‘not concerned’ about inflation hitting 4% for the first time since 2023. ‘The numbers were great’
EconomyDonald Trump
‘I love the inflation’: Trump is ‘not concerned’ about inflation hitting 4% for the first time since 2023. ‘The numbers were great’
By The Associated Press and Christopher RugaberJune 10, 2026
30 minutes ago
A man guides a ship in the water.
EnergyOil
Analysts expected oil to surge above $200 but China has quietly kept prices half of that—and can’t for much longer
By Sasha RogelbergJune 10, 2026
1 hour ago
Meryl Streep says she was ‘ready to retire’ when the call for ‘Devil Wears Prada 2’ came—so she demanded they double her salary or nothing
SuccessThe Promotion Playbook
Meryl Streep says she was ‘ready to retire’ when the call for ‘Devil Wears Prada 2’ came—so she demanded they double her salary or nothing
By Orianna Rosa RoyleJune 10, 2026
5 hours ago
Kevin Warsh (L) shakes hands with U.S. President Donald Trump after being sworn in as the new Chairman of the Federal Reserve in the East Room of the White House on May 22, 2026 in Washington, DC.
EconomyInflation
Inflation is back above 4% for the first time since 2023—but Kevin Warsh might catch a break
By Eva RoytburgJune 10, 2026
6 hours ago
swiss
EuropeImmigration
Switzerland to cast world’s first ever vote on whether to cap population
By Jamey Keaten and The Associated PressJune 10, 2026
6 hours ago
Top CD rates from major banks on June 10, 2026: Chase CDs, Bank of America CDs, Citibank CDs, and more
Personal FinanceCertificates of Deposit (CDs)
Top CD rates from major banks on June 10, 2026: Chase CDs, Bank of America CDs, Citibank CDs, and more
By Joseph HostetlerJune 10, 2026
6 hours ago

Most Popular

Pentagon accuses Alibaba, Baidu and BYD, three of China's biggest companies, of supporting the Chinese military
Asia
Pentagon accuses Alibaba, Baidu and BYD, three of China's biggest companies, of supporting the Chinese military
By Kate O'Keeffe and BloombergJune 8, 2026
2 days ago
'We are rapidly running out of time': Watchdog sounds Social Security alarm after 22% cut confirmed for 2032
Economy
'We are rapidly running out of time': Watchdog sounds Social Security alarm after 22% cut confirmed for 2032
By Nick LichtenbergJune 9, 2026
1 day ago
Costco CEO Ron Vachris rose from forklift driver to the C-suite without a college degree: ‘Don’t chase a title’ is the career advice that got him there
Success
Costco CEO Ron Vachris rose from forklift driver to the C-suite without a college degree: ‘Don’t chase a title’ is the career advice that got him there
By Preston ForeJune 8, 2026
2 days ago
Current price of oil as of June 9, 2026
Personal Finance
Current price of oil as of June 9, 2026
By Joseph HostetlerJune 9, 2026
1 day ago
Wall Street dumped nearly $1 trillion in tech stocks by midday—then clawed it back and bought peanut butter and paint
Investing
Wall Street dumped nearly $1 trillion in tech stocks by midday—then clawed it back and bought peanut butter and paint
By Eva RoytburgJune 9, 2026
22 hours ago
Current price of silver as of Tuesday, June 9, 2026
Personal Finance
Current price of silver as of Tuesday, June 9, 2026
By Joseph HostetlerJune 9, 2026
1 day ago

© 2026 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.