• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia
HealthCoronavirus

COVID-19 will soon surpass the Spanish flu as America’s deadliest pandemic

By
Lance Lambert
Lance Lambert
Former Real Estate Editor
Down Arrow Button Icon
By
Lance Lambert
Lance Lambert
Former Real Estate Editor
Down Arrow Button Icon
September 16, 2021, 11:32 AM ET

As of Wednesday, the deaths of 666,816 people in the United States—including 13,600 just over the past week—have been attributed to COVID-19.

That mounting death count will soon render the COVID-19 pandemic as America’s deadliest.

The number of deaths from the coronavirus pandemic have already surpassed those from the 1968 flu ( an estimated 100,000). At their current pace, COVID-related deaths will also surpass the 675,000 estimated U.S. deaths caused by the 1918 Spanish flu pandemic—the deadliest in U.S. history—before the end of September.

While deaths attributed to COVID-19 are likely to surpass those from the Spanish flu, it doesn’t mean the coronavirus pandemic is the deadlier of the two: On a per capita basis, the Spanish flu pandemic—caused by the H1N1 Influenza A virus—killed a much higher percentage of the nation than COVID-19. In 1920, the U.S. population stood at 106 million, compared with 331.5 million in 2020.

Because there was no vaccine or antibiotic treatment for the Spanish flu, there was a higher mortality rate than for COVID-19, affecting, according to the CDC, all age groups over age 5. As the CDC writes: “High mortality in healthy people, including those in the 20–40 year age group, was a unique feature of [the 1918] pandemic.”

While COVID-19 will soon become the deadliest pandemic in U.S. history, it won’t come close globally. In fact, it won’t even surpass the 1918 influenza pandemic: Globally, COVID-19 has claimed nearly 4.7 million lives, according to data collected by John Hopkins University, compared with the estimated 50 million killed globally between 1918 and 1919 by the Spanish flu.

We should note that death counts for both the 1918 Spanish flu and the 1968 flu pandemic are rough estimates. The lack of data reporting, in particular amid the Spanish flu, makes pinning down the number of fatalities very challenging.

More health care and Big Pharma coverage from Fortune:

  • India’s Kerala state was a COVID-19 success story. Now the “Kerala model” appears to be faltering
  • Vaccine mandates pick up steam, but few employers say they’ll fire violators
  • The U.K. terminates its COVID vaccine contract with Valneva—wiping out almost half its market cap
  • Delta used this “negative incentive” strategy to get employees vaccinated
  • Its COVID-19 vaccine bogged down in trials, Sanofi to manufacture BioNTech/Pfizer doses

Subscribe to Fortune Daily to get essential business stories straight to your inbox each morning.

About the Author
By Lance LambertFormer Real Estate Editor
Twitter icon

Lance Lambert is a former Fortune editor who contributes to the Fortune Analytics newsletter.

See full bioRight Arrow Button Icon

Latest in Health

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025

Most Popular

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • Future 50
  • World’s Most Admired Companies
  • See All Rankings
Sections
  • Finance
  • Leadership
  • Success
  • Tech
  • Asia
  • Europe
  • Environment
  • Fortune Crypto
  • Health
  • Retail
  • Lifestyle
  • Politics
  • Newsletters
  • Magazine
  • Features
  • Commentary
  • Mpw
  • CEO Initiative
  • Conferences
  • Personal Finance
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
About Us
  • About Us
  • Editorial Calendar
  • Press Center
  • Work At Fortune
  • Diversity And Inclusion
  • Terms And Conditions
  • Site Map

Latest in Health

Simple App as best intermittent fasting app
HealthDietary Supplements
The Best Nutrition Apps of 2026: Approved by Experts
By Christina SnyderJanuary 7, 2026
23 hours ago
HealthFood and drink
RFK Jr.  is pushing Americans to eat more red meat and dairy as Starbucks, Chipotle, and others cash in on protein craze
By Tristan BoveJanuary 7, 2026
1 day ago
Photo of Sam Altman
AIHealth
OpenAI launches ChatGPT Health in a push to become a hub for personal health data
By Sharon GoldmanJanuary 7, 2026
1 day ago
HealthChatGPT
OpenAI suggests ChatGPT play doctor as millions of Americans face spiking insurance costs: ‘In the U.S., ChatGPT has become an important ally’
By Tristan BoveJanuary 7, 2026
1 day ago
Lonely young woman in office
SuccessWorkplace Wellness
Staff at a major Swedish pharmacy chain are being paid to take time off with friends to combat loneliness—they can even text loved ones during the $100 ‘friendship hour’
By Emma BurleighJanuary 7, 2026
1 day ago
flu season
PoliticsFlu Season
You’re not just imagining it—this flu season is officially severe with 45 states reporting high or very high activity
By Mike Stobbe and The Associated PressJanuary 6, 2026
2 days ago

© 2025 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.


Most Popular

placeholder alt text
Law
Amazon is cutting checks to millions of customers as part of a $2.5 billion FTC settlement. Here's who qualifies and how to get paid
By Sydney LakeJanuary 6, 2026
2 days ago
placeholder alt text
Economy
Mark Cuban on the $38 trillion national debt and the absurdity of U.S. healthcare: we wouldn't pay for potato chips like this
By Nick LichtenbergJanuary 6, 2026
2 days ago
placeholder alt text
Future of Work
AI layoffs are looking more and more like corporate fiction that's masking a darker reality, Oxford Economics suggests
By Nick LichtenbergJanuary 7, 2026
23 hours ago
placeholder alt text
Future of Work
'Employers are increasingly turning to degree and GPA' in hiring: Recruiters retreat from ‘talent is everywhere,’ double down on top colleges
By Jake AngeloJanuary 6, 2026
2 days ago
placeholder alt text
Success
MacKenzie Scott sends millions to nonprofit that supports anti-Israel and pro-Muslim groups, two of which are facing federal probes
By Sydney LakeJanuary 6, 2026
2 days ago
placeholder alt text
Personal Finance
Current price of silver as of Wednesday, January 7, 2026
By Joseph HostetlerJanuary 7, 2026
1 day ago