• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia

Trendingnow

1

'We didn’t see this coming': Wall Street eats its forecasts as stocks sell off globally on fear of AI bubble ahead of SpaceX IPO

2

Gen Zers are arriving at college unable to even read a sentence—professors warn it could lead to a generation of anxious and lonely graduates

3

Trump, who has repeatedly called climate change fake, is now threatening Brazil with tariffs over the deforestation of the Amazon

1

'We didn’t see this coming': Wall Street eats its forecasts as stocks sell off globally on fear of AI bubble ahead of SpaceX IPO

2

Gen Zers are arriving at college unable to even read a sentence—professors warn it could lead to a generation of anxious and lonely graduates

3

Trump, who has repeatedly called climate change fake, is now threatening Brazil with tariffs over the deforestation of the Amazon
Health

The History of the Flu Shot and Some Common Misconceptions

By
Grace Donnelly
Grace Donnelly
Down Arrow Button Icon
By
Grace Donnelly
Grace Donnelly
Down Arrow Button Icon
January 19, 2018, 11:17 AM ET

Nearly 6% of all Americans seeking medical care now have flu symptoms and at least 22 children have been killed by the influenza virus so far this year. The flu kills about 12,000 Americans in a mild year and up to 56,000 in particularly severe years, according to estimates from the Centers for Disease Control.

But in the 13 years that the CDC has used its current flu-tracking system, this is the first season that flu activity has been so widespread across the entire U.S., according to Dan Jernigan, director of the influenza division at the national Center for Immunization and Respiratory Diseases.

“Flu is everywhere in the U.S. right now,” Jernigan said, “This is the first year we have had the entire continental U.S. be the same color on the graph, meaning there is widespread activity in all of the continental U.S. at this point.”

The state of Alabama declared a public health emergency due to the size of the outbreak there and 34 people in San Francisco died from flu-related causes during the last week of 2017.

Experts have said we may be at peak volume for flu cases, but it’s not too late to get a flu shot.

Although the flu vaccine varies in effectiveness from year to year and works best when administered in the fall before the season ramps up, flu shots can still save lives even when they don’t prevent people from contracting the virus. Here’s why it’s important that everyone take advantage of this modern medicine during flu season.

How was the flu vaccine created?

Scientists had a working flu vaccine by the 1940s, after the influenza virus was first discovered in the early 1930s.

Soldiers fighting in World War II were the first patients to receive the flu vaccine when it was approved for military use in 1945 and civilian use was approved the following year.

Thomas Francis Jr., MD, and Jonas Salk, MD, who are more famously known for developing a vaccine for polio, were both integral to developing the flu vaccine.

Thomas Francis;Jonas E. Salk
Inventor of the polio vaccine Dr. Jonas E. Salk (C) standing with Thomas Francis (L) during a press conference. (Photo by Al Fenn/The LIFE Picture Collection/Getty Images)Al Fenn/The LIFE Picture Collection/Getty Images
Al Fenn—The LIFE Picture Collection/Getty Images

The earliest flu shots protected against a single strain of the disease, influenza A. In 1942, after the discovery of influenza B, a bivalent vaccine, which protected against influenza A and influenza B, was produced. As scientists learned more about the virus and the ways it mutates, the World Health Organization (WHO) developed a more rigorous process for targeting the strains that affect the most people which was instituted in 1973.

How effective are flu shots?

Today, flu shots contain three strains of the virus. The WHO determines which strains to include based on how the virus has mutated over the past year and where it is spreading. The trivalent vaccine combines two strains of the influenza A virus and one strain of influenza B in order to prompt your immune system to develop antibodies for all three versions of the flu.

It takes about two weeks after you get a flu shot for your body to build immunity.

But it’s still a guessing game. There are four species of the flu virus — A, B, C, and D — with the most common being strains of A or B viruses. Most years the flu shots produced are between 40% and 60% effective.

A doctor with his syringe makes ready to give anti-flu vaccine to Margaret Ayre, who plays Snow White and the rest of th
A doctor with his syringe makes ready to give anti-flu vaccine to Margaret Ayre, who plays Snow White and the rest of the cast at the City Varieties, Leeds in December 1969.WATFORD/Mirrorpix/Mirrorpix via Getty Images
Watford—Mirrorpix via Getty Images

“The holy grail is to target a piece of the virus by antibody or t cell,” Tom Evans, the CEO of a company called Vaccitech that is working on a universal vaccine they hope can be used to treat all strains of influenza A, told National Geographic.

Typically two A strains are the most common during peak flu season: H1N1 and H3N2. This year, the H3N2 strain is particularly nasty and prevalent — more than 80% of all cases this season involve this type of flu virus, according to CDC data.

“H3N2 is a bad virus,” Jernigan, the CDC official, said. “We hate H3N2.”

To make matters worse, the 2017 vaccine doesn’t combat this more severe strain of H3N2 very well. It’s still too soon to know for sure, but public health experts predict the current flu shot will only have 10% to 30% efficacy.

What is the flu vaccine made of?

The flu vaccine contains a cocktail of three or four strands of either the inactivated influenza virus or particles designed to look like those viruses to your immune system. Early versions of the flu shot were not as purified as modern vaccines which sometimes contributed to side effects like fever, aches, and fatigue.

just finished his vaccination
a boy just had his vaccination, and show me the position on the arm.D.Jiang/Getty Images
D.Jiang—Getty Images

This likely led to the misconception that you can contract the flu from the flu shot, but that simply isn’t true. Some people do still experience side effects like headache, fever, and nausea after getting vaccinated, but it’s not possible to contract the influenza virus from the shot, according to the CDC.

Another common concern is that flu shots contain mercury. The flu vaccine does contain a preservative called thimerosal, which breaks down to ethylmercury once inside the body. However this is not the form of the element that causes mercury toxicity. That, in case you’re wondering, is methylmercury.

About the Author
By Grace Donnelly
See full bioRight Arrow Button Icon

Latest in

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025

Most Popular

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Fortune Secondary Logo
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • World's Most Admired Companies
  • See All Rankings
  • Lists Calendar
Sections
  • Finance
  • Fortune Crypto
  • Features
  • Leadership
  • Health
  • Commentary
  • Success
  • Retail
  • Mpw
  • Tech
  • Lifestyle
  • CEO Initiative
  • Asia
  • Politics
  • Conferences
  • Europe
  • Newsletters
  • Personal Finance
  • Environment
  • Magazine
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
  • Group Subscriptions
About Us
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • Facebook icon
  • Twitter icon
  • LinkedIn icon
  • Instagram icon
  • Pinterest icon

Latest in

Best Workplaces in New York
Best Small and Medium Workplaces in New York
By FortuneJune 9, 2026
27 minutes ago
Best Workplaces in New York
Best Large Workplaces in New York
By FortuneJune 9, 2026
27 minutes ago
noah
SuccessMedia
This CEO keeps going viral for thirst-trapping journalists with $200,000 jobs to be head of content. Yes, he’s trying to prove a point
By Nick LichtenbergJune 9, 2026
27 minutes ago
Boris Cherny, head of Claude Code at Anthropic and Fortune's AI Editor Jeremy Kahn on June 8, 2026 at the Fortune Brainstorm Tech conference in Aspen.
NewslettersCFO Daily
The man behind Claude Code says you’re comparing AI costs to the wrong thing
By Sheryl EstradaJune 9, 2026
50 minutes ago
The Big Story: SpaceX IPO means more to the Gulf than you might expect
NewslettersFortune Gulf Brief
The Big Story: SpaceX IPO means more to the Gulf than you might expect
By Melissa HancockJune 9, 2026
51 minutes ago
‘We expect it to leak’: OpenAI is frontrunning the narrative around its $1 trillion IPO
AIMarkets
‘We expect it to leak’: OpenAI is frontrunning the narrative around its $1 trillion IPO
By Jim EdwardsJune 9, 2026
1 hour ago

Most Popular

'We didn’t see this coming': Wall Street eats its forecasts as stocks sell off globally on fear of AI bubble ahead of SpaceX IPO
Economy
'We didn’t see this coming': Wall Street eats its forecasts as stocks sell off globally on fear of AI bubble ahead of SpaceX IPO
By Jim EdwardsJune 8, 2026
1 day ago
Gen Zers are arriving at college unable to even read a sentence—professors warn it could lead to a generation of anxious and lonely graduates
Success
Gen Zers are arriving at college unable to even read a sentence—professors warn it could lead to a generation of anxious and lonely graduates
By Preston ForeJune 7, 2026
2 days ago
Trump, who has repeatedly called climate change fake, is now threatening Brazil with tariffs over the deforestation of the Amazon
Environment
Trump, who has repeatedly called climate change fake, is now threatening Brazil with tariffs over the deforestation of the Amazon
By Sasha RogelbergJune 8, 2026
15 hours ago
Current price of oil as of June 8, 2026
Personal Finance
Current price of oil as of June 8, 2026
By Joseph HostetlerJune 8, 2026
22 hours ago
'The golden years are not golden': Boomers are hoarding most of America's wealth and power because they're terrified of outliving their money
Economy
'The golden years are not golden': Boomers are hoarding most of America's wealth and power because they're terrified of outliving their money
By Nick LichtenbergJune 7, 2026
2 days ago
Current price of silver as of Monday, June 8, 2026
Personal Finance
Current price of silver as of Monday, June 8, 2026
By Joseph HostetlerJune 8, 2026
22 hours ago

© 2026 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.