• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia

Trendingnow

1

'Work hard, stay loyal, and the system will reward you': the Boomer credo is a Gen X betrayal and a Millennial pipe dream

2

Current price of oil as of June 16, 2026

3

Hundreds of Stanford students walked out of their grad ceremony to protest Google CEO’s commencement speech. It wasn’t all about AI

1

'Work hard, stay loyal, and the system will reward you': the Boomer credo is a Gen X betrayal and a Millennial pipe dream

2

Current price of oil as of June 16, 2026

3

Hundreds of Stanford students walked out of their grad ceremony to protest Google CEO’s commencement speech. It wasn’t all about AI
HealthEli Lilly

Eli Lilly to Continue Breakthrough Breast Cancer Drug Trial Despite Failed Test

By
Reuters
Reuters
Down Arrow Button Icon
By
Reuters
Reuters
Down Arrow Button Icon
August 11, 2016, 11:37 AM ET
Eli Lilly & Co Chief Executive Officer John Lechleiter Interview
John Lechleiter, chairman, president and chief executive officer of Eli Lilly & Co., speaks during a Bloomberg Television interview in San Francisco, U.S., on Wednesday, Jan. 13, 2016. Lechleiter discussed lost patents, late stage drug pipeline, and clarity on drug pricing. Photographer: David Paul Morris/Bloomberg via Getty ImagesPhoto by David Paul Morris/Bloomberg via Getty Images
Add Fortune on Google for similar content.

U.S. drugmaker Eli Lilly (LLY) on Wednesday said it would continue a late-stage trial of its experimental breast cancer drug in combination with a widely used treatment even though an independent panel determined the combination therapy failed to meet its interim effectiveness goal.

The independent data monitoring committee recommended the trial continue without modification through the first half of 2017 despite the fact that its interim look at the data suggested the combination treatment was not delaying progression of the disease.

Lilly shares were down 1.2% in morning trading.

Leerink analyst Seamus Fernandez said continuation of the study, called Monarch 2, would allow Lilly to better understand abemaciclib, which is also being tested in a variety of other trials.

 

The Monarch 2 study included 669 patients who had previously failed to benefit from anti-estrogen treatment for metastatic breast cancer. It compared combined use of abemaciclib and anti-estrogen therapy fulvestrant with fulvestrant alone.

These Are the Most Promising Experimental Cancer Drugs

Lilly’s drug is from the same new class of breast cancer treatments as Pfizer’s (PFE) recently approved Ibrance, which brought in more than half a billion dollars in second-quarter sales. They work through a new mechanism, by blocking the proteins CDK 4 and CDK 6.

Lilly is evaluating abemaciclib as a single agent in breast cancer patients who have not derived enough benefit from prior treatments. Three other studies are testing abemaciclib with other drugs.

Abemaciclib, which was granted the U.S. Food and Drug Administration’s (FDA) breakthrough therapy status for breast cancer last year, is also being tested for use in lung cancer.

What You Need to Know About the World’s Biggest Cancer Conference

After skin cancer, breast cancer is the most common cancer among women in the United States, according to the U.S. Centers for Disease Control and Prevention (CDC).

About 40,000 of the 220,000 American women diagnosed with breast cancer die each year, the CDC estimates.

About the Author
By Reuters
See full bioRight Arrow Button Icon
Add Fortune on Google for similar content.

Latest in Health

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025

Most Popular

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Fortune Secondary Logo
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • World's Most Admired Companies
  • See All Rankings
  • Lists Calendar
Sections
  • Finance
  • Fortune Crypto
  • Features
  • Leadership
  • Health
  • Commentary
  • Success
  • Retail
  • Mpw
  • Tech
  • Lifestyle
  • CEO Initiative
  • Asia
  • Politics
  • Conferences
  • Europe
  • Newsletters
  • Personal Finance
  • Environment
  • Magazine
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
  • Group Subscriptions
About Us
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • Facebook icon
  • Twitter icon
  • LinkedIn icon
  • Instagram icon
  • Pinterest icon

Latest in Health

Needles used to detect breast cancer in shortage from recall
Healthbreast cancer
Needles used to detect breast cancer in shortage from recall
By Annika Inampudi, Anna Edney and BloombergJune 17, 2026
1 hour ago
Best Father’s Day Gifts (2026): Make Dad’s Day Special
HealthDietary Supplements
Best Father’s Day Gifts (2026): Make Dad’s Day Special
By Christina SnyderJune 17, 2026
2 hours ago
Abhinav Agarwal and Jenny Duan
Startups & VentureBiotech
Exclusive: A 21-year-old Stanford grad just raised $11 million to put a hormone lab on your wrist
By Lily Mae LazarusJune 17, 2026
9 hours ago
He fled Iran for the American Dream, became a millionaire, and could have retired—instead, he built the health tech that saved his father from cancer
SuccessFortune The Good Life
He fled Iran for the American Dream, became a millionaire, and could have retired—instead, he built the health tech that saved his father from cancer
By Orianna Rosa RoyleJune 17, 2026
15 hours ago
‘It’s on us’: Luigi Mangione’s hearing delayed after DA failed to request him from jail
Lawcourts
‘It’s on us’: Luigi Mangione’s hearing delayed after DA failed to request him from jail
By Michael R. Sisak and The Associated PressJune 16, 2026
1 day ago
Infant mortality in the U.S. fell to an all-time low in 2025 thanks to antibody shots and RSV vaccines
Healthlife expectancy
Infant mortality in the U.S. fell to an all-time low in 2025 thanks to antibody shots and RSV vaccines
By Mike Stobbe and The Associated PressJune 16, 2026
1 day ago

Most Popular

'Work hard, stay loyal, and the system will reward you': the Boomer credo is a Gen X betrayal and a Millennial pipe dream
Success
'Work hard, stay loyal, and the system will reward you': the Boomer credo is a Gen X betrayal and a Millennial pipe dream
By Nick LichtenbergJune 16, 2026
1 day ago
Current price of oil as of June 16, 2026
Personal Finance
Current price of oil as of June 16, 2026
By Joseph HostetlerJune 16, 2026
1 day ago
Hundreds of Stanford students walked out of their grad ceremony to protest Google CEO’s commencement speech. It wasn’t all about AI
Big Tech
Hundreds of Stanford students walked out of their grad ceremony to protest Google CEO’s commencement speech. It wasn’t all about AI
By Tristan BoveJune 15, 2026
2 days ago
Exclusive: Universal beat Disney as Hollywood's maker of the most expensive movie of all time 
Arts & Entertainment
Exclusive: Universal beat Disney as Hollywood's maker of the most expensive movie of all time 
By Christian SyltJune 17, 2026
11 hours ago
Current price of oil as of June 17, 2026
Personal Finance
Current price of oil as of June 17, 2026
By Joseph HostetlerJune 17, 2026
9 hours ago
Melinda French Gates' advice to new IPO millionaires: 'Give half your money away'
Startups & Venture
Melinda French Gates' advice to new IPO millionaires: 'Give half your money away'
By Emma HinchliffeJune 13, 2026
4 days ago

© 2026 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.