• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia
LifestyleBrain

What happens to your brain when you work too many hours, according to new research

By
Alexa Mikhail
Alexa Mikhail
Senior Reporter, Fortune Well
Down Arrow Button Icon
By
Alexa Mikhail
Alexa Mikhail
Senior Reporter, Fortune Well
Down Arrow Button Icon
May 21, 2025, 5:26 AM ET
New research finds an association between working too many hours and the brain's structure.
New research finds an association between working too many hours and the brain's structure. Tero Vesalainen—Getty Images

We all know that working long hours leaves us exhausted. But overworking has far-reaching effects on our health. It’s linked to an increase in stress, lack of sleep, and lower emotional well-being. 

Recommended Video

Now, new research published in the journal Occupational & Environmental Medicine suggests that working long hours can even change the brain’s physical structure. 

To conduct the study, researchers from Korea reviewed the working hours and MRIs of over 100 health care workers between 2021 and 2023. Those who worked 52 hours or more per week were classified as overworkers. 

The researchers discovered changes in the brain structure of overworkers, particularly in regions that account for emotional processing and executive functioning. The results suggest that “the increased brain volumes observed in overworked individuals may reflect neuroadaptive responses to chronic occupational stress, although the exact mechanisms remain speculative,” wrote the researchers. 

One explanation for the brain changes is that overworking can disrupt sleep, which can, in turn, heighten the stress response and increase the risk for mental health conditions like anxiety and depression. 

“Overwork is a combination of physical and emotional overexertion and a lack of rest. Overuse and lack of rest can negatively affect the brain,” the researchers conclude. 

However, the researchers note that their conclusions are “preliminary” and call for further research, such as whether these structural changes can affect the brain into old age and cause changes in decision making and emotional regulation.

“Future research should explore the long-term implications of these structural brain changes and whether they lead to cognitive decline or mental health disorders,” the paper concludes. 

For now, people can take steps to help protect their brain health even if work feels like a slog, like sleeping at least seven hours a night, limiting screen time, and taking micro breaks during the workday. 

Join us at the Fortune Workplace Innovation Summit May 19–20, 2026, in Atlanta. The next era of workplace innovation is here—and the old playbook is being rewritten. At this exclusive, high-energy event, the world’s most innovative leaders will convene to explore how AI, humanity, and strategy converge to redefine, again, the future of work. Register now.
About the Author
By Alexa MikhailSenior Reporter, Fortune Well
LinkedIn iconTwitter icon

Alexa Mikhail is a former senior health and wellness reporter for Fortune Well, covering longevity, aging, caregiving, workplace wellness, and mental health.

See full bioRight Arrow Button Icon

Latest in Lifestyle

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025

Most Popular

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Fortune Secondary Logo
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • Future 50
  • World’s Most Admired Companies
  • See All Rankings
Sections
  • Finance
  • Fortune Crypto
  • Features
  • Leadership
  • Health
  • Commentary
  • Success
  • Retail
  • Mpw
  • Tech
  • Lifestyle
  • CEO Initiative
  • Asia
  • Politics
  • Conferences
  • Europe
  • Newsletters
  • Personal Finance
  • Environment
  • Magazine
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
  • Group Subscriptions
About Us
  • About Us
  • Editorial Calendar
  • Press Center
  • Work At Fortune
  • Diversity And Inclusion
  • Terms And Conditions
  • Site Map
  • About Us
  • Editorial Calendar
  • Press Center
  • Work At Fortune
  • Diversity And Inclusion
  • Terms And Conditions
  • Site Map
Fortune Secondary Logo
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • Future 50
  • World’s Most Admired Companies
  • See All Rankings
Sections
  • Finance
  • Fortune Crypto
  • Features
  • Leadership
  • Health
  • Commentary
  • Success
  • Retail
  • Mpw
  • Tech
  • Lifestyle
  • CEO Initiative
  • Asia
  • Politics
  • Conferences
  • Europe
  • Newsletters
  • Personal Finance
  • Environment
  • Magazine
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
  • Group Subscriptions
About Us
  • About Us
  • Editorial Calendar
  • Press Center
  • Work At Fortune
  • Diversity And Inclusion
  • Terms And Conditions
  • Site Map
  • About Us
  • Editorial Calendar
  • Press Center
  • Work At Fortune
  • Diversity And Inclusion
  • Terms And Conditions
  • Site Map
  • Facebook icon
  • Twitter icon
  • LinkedIn icon
  • Instagram icon
  • Pinterest icon

Latest in Lifestyle

long lines TSA
North AmericaAirline industry
War, oil, and an unpaid TSA: The perfect storm of travel chaos feels like the pandemic all over again
By Catherina GioinoMarch 19, 2026
7 hours ago
Dua Lipa poses
Arts & EntertainmentNestle
Nespresso’s Dua Lipa era marks a shift from George Clooney’s activism to Gen Z aspiration 
By Jacqueline MunisMarch 19, 2026
10 hours ago
Stephan Winkelmann, wearing a dark blue suit, speaks in front of a black background with the Lamborghini logo on it.
RetailAutos
Lamborghini is selling a record number of cars—but tariffs are eating its profits
By Sasha RogelbergMarch 19, 2026
19 hours ago
HealthDietary Supplements
The Best Shampoos for Thinning Hair of 2026: Tester Approved
By Christina SnyderMarch 18, 2026
1 day ago
Alan Bergman, Josh D'Amaro and Dana Walden pose
C-SuiteDisney
Today’s Bob Iger’s last day leading Disney. Here’s what comes next at the company worth $176 billion
By Jacqueline MunisMarch 18, 2026
1 day ago
Josh D'Amaro
SuccessCareers
Disney’s new CEO Josh D’Amaro once planned to be a sculptor. He admits ‘I don’t know’ is one of the most important phrases in his career
By Preston ForeMarch 18, 2026
1 day ago

Most Popular

placeholder alt text
Success
Less than 10 out of 250 billionaires have kept their promise to give away their fortune—and a philanthropy CEO says Elon Musk is right about why
By Orianna Rosa RoyleMarch 18, 2026
2 days ago
placeholder alt text
Law
DOGE cancelled a $349,000 grant to replace a museum’s HVAC after ChatGPT flagged it as DEI, court documents show
By Sasha RogelbergMarch 19, 2026
8 hours ago
placeholder alt text
Economy
Jerome Powell says you're right to blame data centers for making your bills more expensive: 'probably pushing inflation up'
By Eva RoytburgMarch 19, 2026
12 hours ago
placeholder alt text
Economy
Social Security has 6 years left. The fix that sounds cruelest may be the smartest
By Nick LichtenbergMarch 19, 2026
8 hours ago
placeholder alt text
Economy
The national debt just crossed $39 trillion—almost doubling since Trump vowed to erase it
By Nick LichtenbergMarch 18, 2026
1 day ago
placeholder alt text
Commentary
The U.S. attacked Iran to show its power but the war is already lost. Epic Fury looks like an Epic Fail
By Guillaume LongMarch 18, 2026
1 day ago

© 2026 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.