• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia
TechAI

Anthropic hired president Daniela Amodei’s husband to work on the company’s AI safety strategy

By
Jessica Mathews
Jessica Mathews
and
Sharon Goldman
Sharon Goldman
Down Arrow Button Icon
By
Jessica Mathews
Jessica Mathews
and
Sharon Goldman
Sharon Goldman
Down Arrow Button Icon
February 13, 2025, 4:11 PM ET
Daniela Amodei, co-founder and president of Anthropic
Daniela Amodei, co-founder and president of Anthropic

Anthropic, the fast-growing AI company currently valued at $60 billion, has quietly hired the husband of cofounder and president Daniela Amodei to help craft safety strategy, adding another family connection to the startup helmed by brother and sister Daniela and CEO Dario Amodei.

Recommended Video

Holden Karnofksy, Daniela Amodei’s husband, joined Anthropic last month as a member of the startup’s “technical staff,” a company spokesperson confirmed. The company had not announced Karnofsky’s hiring, but Karnofsky recently updated his LinkedIn profile to reflect his new position. 

Karnofsky is an AI safety researcher and philanthropist closely associated with Effective Altruism, a philanthropical movement whose focuses include AI’s existential risks, and which has garnered both influence and controversy in recent years. Karnofsky also once served on OpenAI’s board.

Karnofsky is working on Anthropic’s “Responsible Scaling Policy,” which is the company’s set of protocols to manage public and societal risk around powerful AI models, according to two people with direct knowledge of the matter and confirmed by Anthropic. Both sources, whose identity is known to Fortune, were granted anonymity because they were not authorized to discuss company matters.

Anthropic confirmed that  Karnofsky is working on trust and safety issues, describing his title only as “a member of the technical staff” reporting to Chief Science Officer Jared Kaplan. 

“He is working on the responsible scaling policy and other aspects around safety planning ahead of highly advanced AI systems,” the spokesperson said.

With Karnofsky’s addition to the company, Anthropic now has three close family members holding influential roles at the company. Siblings Dario and Daniela Amodei were part of a group of early OpenAI employees who left the company in late 2020 to found Anthropic, in part because they were concerned that OpenAI under the leadership of CEO Sam Altman was becoming too focused on commercial products while deemphasizing AI safety research. 

Anthropic also recently hired Niki Parmar, the sole female member of the Google AI research team that in 2017 developed the Transformer, a kind of neural network design on which all of today’s generative AI models are based.  

Parmar had previously cofounded Adept AI, a startup working on AI agents for work, but left before a majority of that company’s team was hired by Amazon last year. She went on to cofound another AI startup, Essential AI, with Ashish Vaswani, who was one of her coauthors on the landmark Transformer research. Vaswani is still CEO of the AI model and product startup – which emerged from stealth in December 2023 with close to $65 million in funding from investors including Google, Nvidia and AMD.

The new hires come around the same time as Anthropic’s new $2 billion funding round, which valued the company at $60 billion in January. The generative AI industry has become exceedingly competitive as rival OpenAI launches a $500 billion initiative, known as the Stargate project, to build AI data centers around the United States, and as other rivals like Elon Musk’s xAI raise billions in capital to train their own models.

Anthropic is under pressure to move quickly and continue to improve its own large language model, Claude, as quickly as possible. The company has yet to release a “reasoning model” similar to OpenAI’s o1 and o3 models, and Chinese AI company DeepSeek’s R1 model, that use a step-by-step “thinking” process to produce more accurate answers for math, coding, and logic questions.

Karnofsky, who served on OpenAI’s board between 2017 and 2021, co-founded Open Philanthropy with Facebook co-founder Dustin Moskowitz and his wife Cari Tuna in 2017. Open Philanthropy is one of the largest funders associated with the Effective Altruism (EA) movement, which came under scrutiny after the collapse of Sam Bankman-Fried’s cryptocurrency exchange FTX.

The movement is known for its focus on existential risks, including the danger that powerful AI could one day wipe out humanity, and Bankman-Fried backed a number of efforts aimed at trying to mitigate this danger. FTX had invested $500 million into Anthropic, and its stake in the AI company was sold off last year for $884 million, with the proceeds going to repaying FTX customers who lost money in the exchange’s collapse. 

Long before officially joining Anthropic, Karnofsky and the Amodei siblings already had close connections. Karnofsky and Dario Amodei were former roommates, and while Karnofsky and Daniela Amodei were engaged, the couple lived with Dario Amodei. 

Clarification: This story has updated to note that “member of technical staff” is Karnofsky’s actual title, according to Anthropic.

Join us at the Fortune Workplace Innovation Summit May 19–20, 2026, in Atlanta. The next era of workplace innovation is here—and the old playbook is being rewritten. At this exclusive, high-energy event, the world’s most innovative leaders will convene to explore how AI, humanity, and strategy converge to redefine, again, the future of work. Register now.
About the Authors
Jessica Mathews
By Jessica MathewsSenior Writer
LinkedIn iconTwitter icon

Jessica Mathews is a senior writer for Fortune covering startups and the venture capital industry.

See full bioRight Arrow Button Icon
Sharon Goldman
By Sharon GoldmanAI Reporter
LinkedIn icon

Sharon Goldman is an AI reporter at Fortune and co-authors Eye on AI, Fortune’s flagship AI newsletter. She has written about digital and enterprise tech for over a decade.

See full bioRight Arrow Button Icon

Latest in Tech

Carl Rinsch
Big TechCrime
Netflix’s $11 million funding for a director’s sports cars and luxury mattresses—not a show—leads to fraud conviction
By The Associated PressDecember 12, 2025
15 minutes ago
Sarandos
CommentaryAntitrust
Netflix, Warner, Paramount and antitrust: Entertainment megadeal’s outcome must follow the evidence, not politics or fear of integration
By Satya MararDecember 12, 2025
30 minutes ago
Elon Musk, wearing a black DOGE hat, looks forward. He is standing in the Oval Office.
PoliticsDOGE
DOGE isn’t dead—it’s been absorbed into the bloodstream of the government, federal employees say
By Sasha RogelbergDecember 12, 2025
35 minutes ago
InvestingMarkets
Retail investors drive stocks to a pre-Christmas all-time high—and Wall Street sees a moment to sell
By Jim EdwardsDecember 12, 2025
1 hour ago
NewslettersTerm Sheet
Disney plus OpenAI: What could possibly go wrong?
By Alexei OreskovicDecember 12, 2025
1 hour ago
Disney CEO Bob Iger in Los Angeles, California on November 20, 2025.(Photo: Unique Nicole/AFP/Getty Images)
NewslettersFortune Tech
Disney and OpenAI do a deal
By Andrew NuscaDecember 12, 2025
2 hours ago

Most Popular

placeholder alt text
Success
At 18, doctors gave him three hours to live. He played video games from his hospital bed—and now, he’s built a $10 million-a-year video game studio
By Preston ForeDecember 10, 2025
2 days ago
placeholder alt text
Investing
Baby boomers have now 'gobbled up' nearly one-third of America's wealth share, and they're leaving Gen Z and millennials behind
By Sasha RogelbergDecember 8, 2025
4 days ago
placeholder alt text
Success
Palantir cofounder calls elite college undergrads a ‘loser generation’ as data reveals rise in students seeking support for disabilities, like ADHD
By Preston ForeDecember 11, 2025
21 hours ago
placeholder alt text
Economy
‘We have not seen this rosy picture’: ADP’s chief economist warns the real economy is pretty different from Wall Street’s bullish outlook
By Eleanor PringleDecember 11, 2025
1 day ago
placeholder alt text
Uncategorized
Transforming customer support through intelligent AI operations
By Lauren ChomiukNovember 26, 2025
16 days ago
placeholder alt text
Economy
‘Be careful what you wish for’: Top economist warns any additional interest rate cuts after today would signal the economy is slipping into danger
By Eva RoytburgDecember 10, 2025
2 days ago
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • Future 50
  • World’s Most Admired Companies
  • See All Rankings
Sections
  • Finance
  • Leadership
  • Success
  • Tech
  • Asia
  • Europe
  • Environment
  • Fortune Crypto
  • Health
  • Retail
  • Lifestyle
  • Politics
  • Newsletters
  • Magazine
  • Features
  • Commentary
  • Mpw
  • CEO Initiative
  • Conferences
  • Personal Finance
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
About Us
  • About Us
  • Editorial Calendar
  • Press Center
  • Work At Fortune
  • Diversity And Inclusion
  • Terms And Conditions
  • Site Map

© 2025 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.