• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia

Trendingnow

1

Pentagon accuses Alibaba, Baidu and BYD, three of China's biggest companies, of supporting the Chinese military

2

'We are rapidly running out of time': Watchdog sounds Social Security alarm after 22% cut confirmed for 2032

3

Costco CEO Ron Vachris rose from forklift driver to the C-suite without a college degree: ‘Don’t chase a title’ is the career advice that got him there

1

Pentagon accuses Alibaba, Baidu and BYD, three of China's biggest companies, of supporting the Chinese military

2

'We are rapidly running out of time': Watchdog sounds Social Security alarm after 22% cut confirmed for 2032

3

Costco CEO Ron Vachris rose from forklift driver to the C-suite without a college degree: ‘Don’t chase a title’ is the career advice that got him there
HealthBiotech

Moderna Had the Biggest Biotech IPO Ever. Here’s What That Says About the Industry’s Future

By
Sy Mukherjee
Sy Mukherjee
Down Arrow Button Icon
By
Sy Mukherjee
Sy Mukherjee
Down Arrow Button Icon
December 8, 2018, 1:30 PM ET

Amid a rocky market that’s whipsawed on a near-daily basis, Moderna Therapeutics pulled off the improbable late Thursday: An historic IPO in which it raised more than $600 million. At a price of $23 per share, Moderna sold more than 26 million shares, setting up an approximately $7.5 billion valuation (although, amid the overall market turbulence and some important questions about the company, Moderna stock still fell nearly 20% in Friday afternoon trading).

Moderna’s $604 million IPO raise is the biggest in biotech history (the firm had originally aimed for a $500 million raise before upping the ante last week). The massive $1.4 billion market value drop on its first trading day on the Nasdaq has raised some recriminations. But the more important longer-term question is: Can Moderna follow through on its ambitious drug development plans, given that it has no products on the market? And what does the case study suggest about the future of biotech IPOs generally?

On the first front: It’s certainly not rare for American biotech companies to go public before having a commercialized product on hand. In fact, money raised in public offerings is often seen as essential by the industry to fund expensive R&D and clinical trials which, admittedly, may end in failure. (I.e., high risk, high reward.)

Moderna’s pipeline is based on something called “mRNA” technology. To put it very simply, this kind of approach could essentially turn the body’s very cells into drug making factories that can then tackle a number of diseases, including cancer, infectious diseases like Zika, the flu, heart disease, and multiple other conditions. Moderna has more than 20 experimental candidates in its pipeline, with the most advanced one in phase 2 clinical trials and the others in phase 1.

The fact that the company has raised so much money, including well before its IPO, without much in the way of evidence that its proposed technology actually works has understandably fostered some criticism. But it’s also indicative of a new age in public biotech investing—one in which companies and investors alike may be more shielded from the risk of devastating clinical trial failures by experimental stage biotechs.

“It used to be that biotechs were a lottery ticket,” Jordan Saxe, head of health care listings at Nasdaq (on which Moderna and the vast majority of newly public biotechs have IPO’d), tells Fortune in an interview. “So what you’d do is buy a portfolio of these companies that are bundled up. So the investor wouldn’t necessarily feel the pain of one company’s failure, the risk was mostly on the company side.”

But the rise of what Saxe calls the “third wave” of biotech IPOs, wherein public companies’ technology has evolved to the point of providing personalized medicine backed by wide-ranging biological platforms (that is, underlying tech that can be used to produce an eclectic mix of drugs across the disease spectrum), has given both drug makers and investors more cover.

“Because of the platform company approach, these biotechs have ten or 12 different assets, not just one,” says Saxe. That means one catastrophic failure doesn’t necessarily spell doom; other products can make up for a miss—if the underlying technology platform (in Moderna’s case, mRNA therapies), actually pans out.

Whether or not that will happen is the multi-billion dollar question. But Saxe expects that public offerings my platform companies will continue to thrive in 2019.

Subscribe to Brainstorm Health Daily, our newsletter about the most exciting health innovations.

About the Author
By Sy Mukherjee
See full bioRight Arrow Button Icon

Latest in Health

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025

Most Popular

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Fortune Secondary Logo
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • World's Most Admired Companies
  • See All Rankings
  • Lists Calendar
Sections
  • Finance
  • Fortune Crypto
  • Features
  • Leadership
  • Health
  • Commentary
  • Success
  • Retail
  • Mpw
  • Tech
  • Lifestyle
  • CEO Initiative
  • Asia
  • Politics
  • Conferences
  • Europe
  • Newsletters
  • Personal Finance
  • Environment
  • Magazine
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
  • Group Subscriptions
About Us
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • Facebook icon
  • Twitter icon
  • LinkedIn icon
  • Instagram icon
  • Pinterest icon

Latest in Health

worm
HealthFood and drink
The pest that could devastate the American cattle industry was in Texas, but now it’s in New Mexico, too
By Jeffrey Collins and The Associated PressJune 9, 2026
20 hours ago
A man put a drink in front of Trump
HealthFood and drink
A Biden-era study told Americans to drink less alcohol. The Trump admin ‘sidelined’ the research facing pressure from the alcohol lobby
By Laura Ungar, Ali Swenson and The Associated PressJune 9, 2026
20 hours ago
Kaged Pre-Workout Review (2026): Athlete Approved
HealthDietary Supplements
Kaged Pre-Workout Review (2026): Athlete Approved
By Christina SnyderJune 8, 2026
2 days ago
Liquid IV Review (2026): Our Personal Experience
HealthDietary Supplements
Liquid IV Review (2026): Our Personal Experience
By Christina SnyderJune 8, 2026
2 days ago
Biotics 8 Review (2026): Expert Tested
HealthDietary Supplements
Biotics 8 Review (2026): Expert Tested
By Emily PharesJune 8, 2026
2 days ago
Jacked Factory Authentic Whey Protein Review (2026)
HealthDietary Supplements
Jacked Factory Authentic Whey Protein Review (2026)
By Emily PharesJune 8, 2026
2 days ago

Most Popular

Pentagon accuses Alibaba, Baidu and BYD, three of China's biggest companies, of supporting the Chinese military
Asia
Pentagon accuses Alibaba, Baidu and BYD, three of China's biggest companies, of supporting the Chinese military
By Kate O'Keeffe and BloombergJune 8, 2026
1 day ago
'We are rapidly running out of time': Watchdog sounds Social Security alarm after 22% cut confirmed for 2032
Economy
'We are rapidly running out of time': Watchdog sounds Social Security alarm after 22% cut confirmed for 2032
By Nick LichtenbergJune 9, 2026
18 hours ago
Costco CEO Ron Vachris rose from forklift driver to the C-suite without a college degree: ‘Don’t chase a title’ is the career advice that got him there
Success
Costco CEO Ron Vachris rose from forklift driver to the C-suite without a college degree: ‘Don’t chase a title’ is the career advice that got him there
By Preston ForeJune 8, 2026
2 days ago
Current price of oil as of June 9, 2026
Personal Finance
Current price of oil as of June 9, 2026
By Joseph HostetlerJune 9, 2026
22 hours ago
Trump, who has repeatedly called climate change fake, is now threatening Brazil with tariffs over the deforestation of the Amazon
Environment
Trump, who has repeatedly called climate change fake, is now threatening Brazil with tariffs over the deforestation of the Amazon
By Sasha RogelbergJune 8, 2026
2 days ago
Current price of silver as of Tuesday, June 9, 2026
Personal Finance
Current price of silver as of Tuesday, June 9, 2026
By Joseph HostetlerJune 9, 2026
22 hours ago

© 2026 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.