• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia

Trendingnow

1

'Dr. Doom' Nouriel Roubini says we're headed for universal basic income or 'some form of socialism' as AI revolutionizes work—He calls that optimistic

2

Power companies are using eminent domain to seize land for data centers as 70% of Americans say not in my backyard

3

Red Lobster’s 37-year-old CEO waited tables before joining the C-suite—he says it was a crash course in managing ‘difficult people and situations’

1

'Dr. Doom' Nouriel Roubini says we're headed for universal basic income or 'some form of socialism' as AI revolutionizes work—He calls that optimistic

2

Power companies are using eminent domain to seize land for data centers as 70% of Americans say not in my backyard

3

Red Lobster’s 37-year-old CEO waited tables before joining the C-suite—he says it was a crash course in managing ‘difficult people and situations’
HealthBiotech

Moderna Had the Biggest Biotech IPO Ever. Here’s What That Says About the Industry’s Future

By
Sy Mukherjee
Sy Mukherjee
Down Arrow Button Icon
By
Sy Mukherjee
Sy Mukherjee
Down Arrow Button Icon
December 8, 2018, 1:30 PM ET
Add Fortune on Google for similar content.

Amid a rocky market that’s whipsawed on a near-daily basis, Moderna Therapeutics pulled off the improbable late Thursday: An historic IPO in which it raised more than $600 million. At a price of $23 per share, Moderna sold more than 26 million shares, setting up an approximately $7.5 billion valuation (although, amid the overall market turbulence and some important questions about the company, Moderna stock still fell nearly 20% in Friday afternoon trading).

Moderna’s $604 million IPO raise is the biggest in biotech history (the firm had originally aimed for a $500 million raise before upping the ante last week). The massive $1.4 billion market value drop on its first trading day on the Nasdaq has raised some recriminations. But the more important longer-term question is: Can Moderna follow through on its ambitious drug development plans, given that it has no products on the market? And what does the case study suggest about the future of biotech IPOs generally?

On the first front: It’s certainly not rare for American biotech companies to go public before having a commercialized product on hand. In fact, money raised in public offerings is often seen as essential by the industry to fund expensive R&D and clinical trials which, admittedly, may end in failure. (I.e., high risk, high reward.)

Moderna’s pipeline is based on something called “mRNA” technology. To put it very simply, this kind of approach could essentially turn the body’s very cells into drug making factories that can then tackle a number of diseases, including cancer, infectious diseases like Zika, the flu, heart disease, and multiple other conditions. Moderna has more than 20 experimental candidates in its pipeline, with the most advanced one in phase 2 clinical trials and the others in phase 1.

The fact that the company has raised so much money, including well before its IPO, without much in the way of evidence that its proposed technology actually works has understandably fostered some criticism. But it’s also indicative of a new age in public biotech investing—one in which companies and investors alike may be more shielded from the risk of devastating clinical trial failures by experimental stage biotechs.

“It used to be that biotechs were a lottery ticket,” Jordan Saxe, head of health care listings at Nasdaq (on which Moderna and the vast majority of newly public biotechs have IPO’d), tells Fortune in an interview. “So what you’d do is buy a portfolio of these companies that are bundled up. So the investor wouldn’t necessarily feel the pain of one company’s failure, the risk was mostly on the company side.”

But the rise of what Saxe calls the “third wave” of biotech IPOs, wherein public companies’ technology has evolved to the point of providing personalized medicine backed by wide-ranging biological platforms (that is, underlying tech that can be used to produce an eclectic mix of drugs across the disease spectrum), has given both drug makers and investors more cover.

“Because of the platform company approach, these biotechs have ten or 12 different assets, not just one,” says Saxe. That means one catastrophic failure doesn’t necessarily spell doom; other products can make up for a miss—if the underlying technology platform (in Moderna’s case, mRNA therapies), actually pans out.

Whether or not that will happen is the multi-billion dollar question. But Saxe expects that public offerings my platform companies will continue to thrive in 2019.

Subscribe to Brainstorm Health Daily, our newsletter about the most exciting health innovations.

About the Author
By Sy Mukherjee
See full bioRight Arrow Button Icon
Add Fortune on Google for similar content.

Latest in Health

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025

Most Popular

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Fortune Secondary Logo
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • World's Most Admired Companies
  • See All Rankings
  • Lists Calendar
Sections
  • Finance
  • Fortune Crypto
  • Features
  • Leadership
  • Health
  • Commentary
  • Success
  • Retail
  • Mpw
  • Tech
  • Lifestyle
  • CEO Initiative
  • Asia
  • Politics
  • Conferences
  • Europe
  • Newsletters
  • Personal Finance
  • Environment
  • Magazine
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
  • Group Subscriptions
About Us
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • Facebook icon
  • Twitter icon
  • LinkedIn icon
  • Instagram icon
  • Pinterest icon

Latest in Health

Ferran Torres
SuccessWorld Cup
Spain’s Ferran Torres scored the winning goal in the World Cup—but just four years ago, he was in therapy and stuck in a ‘bottomless pit’
By Emma BurleighJuly 20, 2026
4 hours ago
FDA walks back positive lab test while lettuce recall continues
HealthFood and drink
FDA walks back positive lab test while lettuce recall continues
By Bloomberg, Kristina Peterson, Jessica Nix and Daniela SirtoriJuly 20, 2026
5 hours ago
Pharmacy technician Brandy Leroy fills a TPN bag using the ExactaMix Pro Automated Compounding System
Startups & VentureTerm Sheet
The FDA’s peptide vote could create telehealth’s next multibillion-dollar market
By Lily Mae LazarusJuly 20, 2026
8 hours ago
A decade after the ‘Godfather of AI’ said radiologists were obsolete, their salaries are up to $571K and demand is growing fast
AIthe future of work
A decade after the ‘Godfather of AI’ said radiologists were obsolete, their salaries are up to $571K and demand is growing fast
By Marco Quiroz-GutierrezJuly 19, 2026
1 day ago
How United’s ‘premiumization’ strategy got passengers to swallow higher airfares without a fight
HealthAirline industry
How United’s ‘premiumization’ strategy got passengers to swallow higher airfares without a fight
By Phil WahbaJuly 19, 2026
2 days ago
Diarrhea-causing lettuce may have spread as wide as 27 states, Taylor Farms recall suggests
HealthFood and drink
Diarrhea-causing lettuce may have spread as wide as 27 states, Taylor Farms recall suggests
By Savannah Peters and The Associated PressJuly 18, 2026
2 days ago

Most Popular

'Dr. Doom' Nouriel Roubini says we're headed for universal basic income or 'some form of socialism' as AI revolutionizes work—He calls that optimistic
AI
'Dr. Doom' Nouriel Roubini says we're headed for universal basic income or 'some form of socialism' as AI revolutionizes work—He calls that optimistic
By Jason MaJuly 18, 2026
2 days ago
Power companies are using eminent domain to seize land for data centers as 70% of Americans say not in my backyard
AI
Power companies are using eminent domain to seize land for data centers as 70% of Americans say not in my backyard
By Aaron Walayat and The ConversationJuly 19, 2026
1 day ago
Red Lobster’s 37-year-old CEO waited tables before joining the C-suite—he says it was a crash course in managing ‘difficult people and situations’
Success
Red Lobster’s 37-year-old CEO waited tables before joining the C-suite—he says it was a crash course in managing ‘difficult people and situations’
By Preston ForeJuly 19, 2026
2 days ago
‘I want to die broke’: Billionaire philanthropist Denny Sanford dies after giving away $4 billion
Success
‘I want to die broke’: Billionaire philanthropist Denny Sanford dies after giving away $4 billion
By Sydney LakeJuly 20, 2026
6 hours ago
Warren Buffett says his $147 billion investing career was an accident: ‘I may be one of the 10 luckiest in the world’
Future of Work
Warren Buffett says his $147 billion investing career was an accident: ‘I may be one of the 10 luckiest in the world’
By Sarah GlodekJuly 20, 2026
12 hours ago
It’s not just Taco Bell lettuce and possible glass in Pillsbury rolls: Food and drink recall events reached a 6-year year-over-year high
Retail
It’s not just Taco Bell lettuce and possible glass in Pillsbury rolls: Food and drink recall events reached a 6-year year-over-year high
By Sasha RogelbergJuly 20, 2026
10 hours ago

© 2026 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.