This New Nanotechnology Could Become the Next Major Cancer Breakthrough

Tampa Florida To Host Republican National Convention
TAMPA, FL - JULY 13: John Winskas, a student in the nanotechnology research and education center at the University of South Florida, looks through a microscope on July 13, 2012 in Tampa, Florida. Tampa has opportunities for employers and employees in such high tech industry as agritechnology, aerospace, digital media, energy technologies, life sciences and medical technologies. The city will host the 2012 Republican National Convention at the Tampa Bay Times Forum August 27-30 where the party is expected to officially nominate former Massachusetts Gov. Mitt Romney as their nominee to face President Barack Obama in November in the general election. The convention will host 2,286 delegates and 2,125 alternate delegates from all 50 states, the District of Columbia and five territories as well as scores of journalists, guests and protesters. (Photo by Joe Raedle/Getty Images)
Photograph by Joe Raedle—via Getty Images

A breakthrough technology that harnesses manmade nanoparticles could one day become an important new weapon in the fight against cancer.

The technique, which appeared to successfully stop the spread of breast cancer in mice, was unveiled by scientists from the Cold Spring Harbor Laboratory, Dana-Farber Cancer Institute, Stony Brook University, and a host of other research institutions in the journal Science Translational Medicine on Wednesday.

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Next-generation cancer fighting therapies on the market today use the body’s immune system to combat tumors, as does experimental technology like CRISPR gene-editing. But the new nanotech has a different target: The cells that actually help cancer metastasize and spread throughout the body.

These immune cells, which are meant to ward off infections, create structures called neutrophil extracellular traps (NETs) that help them fight bacteria. But NETs can actually wind up helping spread the cancer by creating tissue openings that cancerous cells can exploit, study co-author Mikala Egeblad explained to Vice.

So the researchers created a new particle coated with a special enzyme that can kill these cells before the cancer can use them to metastasize. The results were modest, but promising: Three out of the nine mice given the nanoparticle showed no evidence of breast cancer progression, while all mice in the control group continued to worsen.

Still, there are important questions about how effective such a technique might be in humans. NETs are meant to combat bacteria, after all, and destroying them might make cancer patients whose immune systems are already compromised even more vulnerable to infection.

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