1. Bank of New York Mellon

Another feather in Alexander Hamilton’s tricorn cap: The founding father to whom we owe the Federalist papers, the U.S. Coast Guard and Broadway’s hottest musical also started the oldest company on the Fortune 500—Bank of New York Mellon (No. 179). He founded the bank and wrote its constitution in 1784, a time when New York lay in ruins after the Revolutionary War.

2. Cigna

The health insurer (No. 79) traces its roots back to Philadelphia 1792, when a group of entrepreneurs—one aptly named Ebenezer Hazard—formed the Insurance Company of North America. Its first policies were nautical: covering ships and cargo, and life insurance for ship captains.

3. JP Morgan Chase

Founded as The Manhattan Company in 1799 by Aaron Burr—oddly enough with the help of his later duel-mate Alexander Hamilton—the first iteration of J.P. Morgan Chase (No. 23) was ostensibly a water company, formed to fight yellow fever by piping clean water to the residents of New York City. Burr, who had been locked out of the city’s banking industry by rival Federalists, had other motives as well: he slipped into the bank’s charter a clause that allowed the institution to use excess capital in any Constitutionally-acceptable way. Burr’s company never delivered on its water plans, but it was a thriving bank within a few years.

4. DuPont

Run out of revolutionary France, E.I. DuPont, the son of a Parisian watchmaker and printer, moved to the U.S. and began to make explosives in 1802. He had the help of French investors and deep expertise in chemistry and gun powder manufacturing, on which he wrote his first paper at age 14. The business got a boost during the War of 1812 and by 1820, Delaware-based DuPont (no. 101 in 2016) was the leading gun powder supplier to the U.S. government. Later, of course, the company introduced the world to nylon and a wide range of synthetic chemicals.

5. Colgate-Palmolive

Colgate (No. 174) started as a “soap, starch and candle” company in a Manhattan shop house. It began selling toothpaste—in jars—in 1873. In 1896, the company introduced toothpaste in a tube. Today, the company’s brands include Murphy’s Oil, Ajax, and Lady Speed Stick.

6. Hartford Financial Services Group

Founded in 1810 as a fire insurance company, the Connecticut-based insurer (No. 152 this year) initially used its own fire department to protect customers. The company insured Yale—the first policy ever written for such an institution—in 1825, and later counted both Abe Lincoln and Robert E. Lee as customers.