• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia
HealthCoronavirus

Why you have COVID symptoms and a negative test: You may not be doing it right, experts say

By
Erin Prater
Erin Prater
Down Arrow Button Icon
By
Erin Prater
Erin Prater
Down Arrow Button Icon
September 9, 2023, 5:15 AM ET
People are asking the wrong question of at-home COVID tests, one expert tells Fortune.
People are asking the wrong question of at-home COVID tests, one expert tells Fortune.Getty Images

It seems everyone has a “summer cold” these days. If you have hallmark COVID symptoms—headache, runny nose, sore throat, sneezing, cough—but your at–home test says you’re negative, what do you believe: your body or the test?

There are a few possibilities in this scenario, experts tell Fortune. At-home COVID tests “work as well as they always have”—even on new variants like “Pirola” BA.2.86, “Eris” EG.5.1, and “Fornax” FL.1.5.1, Dr. Amesh Adalja, an infectious disease specialist and senior scholar at the Johns Hopkins Center for Health Security, tells Fortune. 

Your test may have given you a false negative, which are far more common than false positives, experts say.

Or you may be performing the test wrong—or at the wrong time.

Are you performing your COVID test wrong?

One reason you might be testing negative when you aren’t: When you performed your nasal swab, you might have sampled a patch of nose that didn’t contain the virus. Or perhaps the patch included the virus, but not enough of it.

“When we sample the nose, we’re grabbing one little patch—a tiny little surface area—when the virus could definitely be replicating somewhere else in the body,” Dr. Stuart Ray, vice chair of medicine for data integrity and analytics at Johns Hopkins’ Department of Medicine, previously told Fortune. 

“The nose is one of the portals through which the virus enters and lives, but it’s also in the mouth and could be harbored deep in the lungs.”

Are you performing your COVID test at the wrong time?

At-home COVID tests not working is a common complaint these days, Raj Rajnarayanan—assistant dean of research and associate professor at the New York Institute of Technology campus in Jonesboro, Ark., and a top COVID variant tracker—tells Fortune.

That’s because you may be testing too early at home. At both the beginning of an infection and at the end, viral loads are not always significant enough to turn a test positive.

Most people with symptoms who test negative initially “test positive after a day or two,” Rajnarayanan says.

What question are you asking your COVID test?

The problem for many people is that they’re asking the wrong question of their at-home COVID test, Adalja says.

Such tests can tell you if you’re able to spread COVID or not—a positive means you are able to, a negative means you’re not able to. But a negative test doesn’t mean you don’t have COVID, Adalja says. It simply means you’re not yet contagious or not contagious anymore, or you may have a different infection causing your symptoms. If you test negative, you may need to test again.

Some additional tips for testing, from the U.S. Centers for Disease Control and Prevention:

  • If you have COVID symptoms, test immediately.
  • If you test negative using an at-home test, repeat the test again in 48 hours.
  • If you were exposed to COVID, test at least 5 full days after exposure.
  • If you test negative using an at-home test, repeat the test again in 48 hours.
  • If you still test negative, wait 48 more hours and test for a final time.
  • In both cases, if you’d rather not wait, you can obtain a PCR, or polymerase chain reaction, test at a doctor’s office. These are more sensitive and tend to be more accurate.
The Fortune 500 Innovation Forum will convene Fortune 500 executives, U.S. policy officials, top founders, and thought leaders to help define what’s next for the American economy, Nov. 16-17 in Detroit. Apply here.
About the Author
By Erin Prater
See full bioRight Arrow Button Icon

Latest in Health

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025

Most Popular

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Fortune Secondary Logo
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • World's Most Admired Companies
  • See All Rankings
  • Lists Calendar
Sections
  • Finance
  • Fortune Crypto
  • Features
  • Leadership
  • Health
  • Commentary
  • Success
  • Retail
  • Mpw
  • Tech
  • Lifestyle
  • CEO Initiative
  • Asia
  • Politics
  • Conferences
  • Europe
  • Newsletters
  • Personal Finance
  • Environment
  • Magazine
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
  • Group Subscriptions
About Us
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • Facebook icon
  • Twitter icon
  • LinkedIn icon
  • Instagram icon
  • Pinterest icon

Latest in Health

A pile of shredded plastic in Vietnam
Healthfertility
Toxic chemicals are raising infertility in humans, fish, birds, and insects: ‘A whisper that is powerful enough to redirect a hurricane’
By Tristan BoveApril 27, 2026
22 hours ago
Meet the founder who started over at 50 and worked 20-hour days to build a multimillion dollar cookie dough empire—and still won’t take a day off
EuropeFortune The Good Life
Meet the founder who started over at 50 and worked 20-hour days to build a multimillion dollar cookie dough empire—and still won’t take a day off
By Orianna Rosa RoyleApril 26, 2026
2 days ago
Hallucinogenics are illegal under federal law but that isn’t stopping the FDA from fast tracking 3 psychedelic drugs to treat mental health
PoliticsFDA
Hallucinogenics are illegal under federal law but that isn’t stopping the FDA from fast tracking 3 psychedelic drugs to treat mental health
By Matthew Perrone and The Associated PressApril 24, 2026
4 days ago
smart glasses
AILondon
AI smart glasses are helping visually impaired runners take on the London Marathon
By The Associated Press and Mustakim HasnathApril 24, 2026
4 days ago
Gainful Protein Review (2026): Expert Tested and Approved
HealthDietary Supplements
Gainful Protein Review (2026): Expert Tested and Approved
By Christina SnyderApril 24, 2026
4 days ago
Exclusive: Michael Boes talks being named the first-ever chief MAHA officer. ‘Nothing’s been off the table’
C-SuiteHealth
Exclusive: Michael Boes talks being named the first-ever chief MAHA officer. ‘Nothing’s been off the table’
By Catherina GioinoApril 24, 2026
4 days ago

Most Popular

Apple cofounder Ronald Wayne—whose stake would be worth up to $400 billion had he not sold it in 1976—says that at 91, he has no regrets
Success
Apple cofounder Ronald Wayne—whose stake would be worth up to $400 billion had he not sold it in 1976—says that at 91, he has no regrets
By Preston ForeApril 27, 2026
24 hours ago
Current price of silver as of Monday, April 27, 2026
Personal Finance
Current price of silver as of Monday, April 27, 2026
By Joseph HostetlerApril 27, 2026
1 day ago
Current price of oil as of April 27, 2026
Personal Finance
Current price of oil as of April 27, 2026
By Joseph HostetlerApril 27, 2026
1 day ago
The U.S. military may have already used up half of its most expensive missiles, and it could take up to 4 years to rebuild its stockpiles
Politics
The U.S. military may have already used up half of its most expensive missiles, and it could take up to 4 years to rebuild its stockpiles
By Sasha RogelbergApril 24, 2026
4 days ago
Current price of gold as of April 27, 2026
Personal Finance
Current price of gold as of April 27, 2026
By Danny BakstApril 27, 2026
1 day ago
Elon Musk says saving for retirement is irrelevant because AI is going to create a world of abundance: 'It won't matter'
Future of Work
Elon Musk says saving for retirement is irrelevant because AI is going to create a world of abundance: 'It won't matter'
By Marco Quiroz-GutierrezApril 26, 2026
2 days ago

© 2026 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.