The government-wide reduction-in-force initiative that began Friday roiled the massive U.S. Department of Health and Human Services just six months after it went through an earlier round of cuts and as many staffers already were disconnected from work because of the shutdown.

The situation turned even more chaotic over the weekend, when more than half of the U.S. Centers for Disease Control and Prevention employees who’d gotten layoff notices learned they received them in error and were still employed with the agency.

HHS, through its agencies, is responsible for tracking health trends and disease outbreaks, conducting and funding medical research, and monitoring the safety of food and medicine, as well as for administering health insurance programs for nearly half the country. Among the HHS agencies facing staff cuts were the CDC, the Substance Abuse and Mental Health Services Administration, or SAMHSA, and the Administration for Strategic Preparedness and Response, or ASPR, according to current and laid-off employees who spoke with The Associated Press.

Former staffers and health professionals said they were concerned the layoffs could have negative health impacts and make it difficult for HHS agencies to fulfill their obligations set by Congress.

HHS spokesperson Andrew Nixon said the laid off employees were deemed nonessential. He added the agency is working to “close wasteful and duplicative entities, including those that are at odds with the Trump administration’s Make America Healthy Again agenda.”

Nixon declined to share which HHS agencies saw layoffs or how many HHS employees were affected. However, a Friday court filing from the Trump administration gave an estimate, saying about 1,100 to 1,200 of the nearly 80,000 staffers at HHS were receiving dismissal notices.

CDC is hit with layoffs — and reversals

About 600 workers at the CDC remained fired Monday in conjunction with the federal government shutdown after hundreds more had originally been targeted, according to the American Federation of Government Employees Local 2883, which represents CDC employees in Atlanta.

Of more than 1,300 CDC employees who received reduction-in-force notices Friday, about 700 later received emails revoking their terminations, the union said.

The AFGE Local 2883 called the action a “politically-motivated stunt” to illegally fire agency workers.

“These reckless actions are disrupting and destroying the lives of everyday working people, who are constantly being used as bargaining chips,” AFGE President Yolanda Jacobs said in a statement Monday.

A federal health official who spoke on condition of anonymity because they were not authorized to discuss the matter with the media said the incorrect RIF notices resulted from a glitch in the system.

Among those targeted for dismissal and then reinstated were the CDC’s Epidemic Intelligence Service officers, the “disease detectives” who are deployed to respond to outbreaks that threaten public health, said Dr. Anne Schuchat, former principal deputy director of the CDC, who said she was in touch with EIS officers in that situation.

“These are people who go into really scary places,” Schuchat said. “Usually you think it’s nature that’s going to be giving you a hard time, the viruses, not the government.”

Mental health services cut in sweeping dismissals at agency

SAMHSA, an agency within HHS devoted to addressing mental illness and addiction, also saw cuts, according to two employees of the agency with knowledge of the layoffs who weren’t authorized to speak publicly.

While the full scope of the firings wasn’t clear, some of the departments affected included the agency’s Office of Communications and the Center for Mental Health Services, where dozens were let go from multiple areas, according to one of the employees.

Within CMHS, one of two branches that oversaw millions of dollars in grants for community health clinics was mostly terminated, the employees said.

Dakota Jablon, a public health analyst and former employee of SAMHSA, said the loss of more staff at SAMHSA, primarily a grantmaking agency, would have “devastating ripple effects across the behavioral health field.”

“Even if the grants continue, the loss of experienced staff means those who remain will be stretched far too thin, often outside their areas of expertise,” she said.

Dr. Eric Rafla-Yuan, a psychiatrist and the chair of the Committee to Protect Public Mental Health, said staff cuts at SAMHSA could put state safety nets for people with mental illness at risk, because the agency provides significant funding and support to state programs.

Latest layoffs build on earlier cuts as HHS looks to restructure

The mass layoffs come six months after thousands of researchers, scientists, doctors, support staff and senior leaders were either laid off from HHS or took early retirement or volunteer separation offers.

The department’s staff was listed at just under 80,000 employees in a contingency plan before the government shutdown began, down more than 2,000 from its staffing level earlier in the year.

The cuts are part of Health Secretary Robert F. Kennedy Jr.’s sweeping effort to remake the department by consolidating agencies that oversee billions of dollars for addiction services and community health centers under a new office called the Administration for a Healthy America. The plan has been delayed amid ongoing legislation and congressional pushback.

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Aleccia reported from Southern California. AP medical writer Mike Stobbe contributed to this report.