• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia
HealthCOVID-19 vaccines

The COVID symptoms you get depend on how many vaccine jabs you’ve had, major study says

By
Chloe Taylor
Chloe Taylor
Down Arrow Button Icon
By
Chloe Taylor
Chloe Taylor
Down Arrow Button Icon
October 27, 2022, 8:02 AM ET
A woman holds a COVID-19 rapid self test device, which displays a positive result.
The COVID symptoms you get depend on how many vaccine doses you’ve had, according to a major study. d3sign/Getty Images

If you’ve ever had COVID, there’s a chance you’re all too familiar with symptoms of the virus, which include a cough, tiredness, and headaches.

But as the virus has evolved and new variants like Delta and Omicron have emerged, its most common symptoms have changed—and now, it seems, which ones you get depends on how many vaccine jabs you’ve had.

Getting vaccinated against COVID reduces your risk of severe illness, hospitalization, and death if you do catch the disease—but according to new research, it could also dictate which batch of the milder, more common symptoms of the virus you end up getting. It’s thought that a large proportion of cases are still asymptomatic.

In an update to the ongoing Zoe Health Study, which has collected data from almost 5 million participants since 2020, researchers said they had identified symptoms that had emerged in recent weeks, noting that they appeared to differ depending on vaccination status.

“Generally, we saw similar symptoms of COVID-19 being reported overall in the app by people who had and hadn’t been vaccinated,” the research team said in its update. “However, fewer symptoms were reported over a shorter period of time by those who had already had a jab, suggesting that they were falling less seriously ill and getting better more quickly.”

Symptoms by vaccination status

The most common current symptoms reported in those who were fully vaccinated, ranked by prevalence, were…

  1. Sore throat
  2. Runny nose
  3. Blocked nose
  4. Persistent cough
  5. Headache

“Traditional” symptoms from the early months of the pandemic, such as loss of smell, fever, and shortness of breath, ranked way down the list in those who had received two doses of a vaccine, researchers said, being named the sixth, eighth, and 29th most common COVID symptoms.

“Curiously, we noticed that people who had been vaccinated and then tested positive for COVID-19 were more likely to report sneezing as a symptom compared with those without a jab,” they added.

Among those who had only had one vaccine dose, the most common recent symptoms were slightly different:

  1. Headache
  2. Runny nose
  3. Sore throat
  4. Sneezing
  5. Persistent cough

In people who were unvaccinated, the study said, the symptoms were “more recognizable to the traditional original ranking,” though they acknowledged there had been some changes from when COVID first appeared.

If you haven’t had a dose of a COVID vaccine, the symptoms you’re most likely to get with the virus—according to the Zoe study—are…

  1. Headache
  2. Sore throat
  3. Runny nose
  4. Fever
  5. Persistent cough

“Loss of smell comes in at No. 9 and shortness of breath comes far down the list at No. 30, indicating the symptoms as recorded previously are changing with the evolving variants of the virus,” the research team said.

Being fully vaccinated and boosted against COVID lowers the risk of becoming severely ill with the virus, particularly if you’re also young and healthy.

However, it’s thought that the Omicron variant and its offspring—like BA.5, which is currently America’s dominant strain of the virus—cause milder illness than their predecessors, even in the unvaccinated.

Globally, COVID infections are on the rise, with experts predicting there will be an uptick in deaths as the Northern Hemisphere heads into its winter months.

In August, Dr. Anthony Fauci, the White House’s top medical adviser, urged Americans to get vaccinated or risk “getting into trouble” over the colder seasons.

Sign up for the Fortune Features email list so you don’t miss our biggest features, exclusive interviews, and investigations.

About the Author
By Chloe Taylor
LinkedIn iconTwitter icon
See full bioRight Arrow Button Icon

Latest in Health

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025

Most Popular

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Fortune Secondary Logo
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • Future 50
  • World’s Most Admired Companies
  • See All Rankings
Sections
  • Finance
  • Fortune Crypto
  • Features
  • Leadership
  • Health
  • Commentary
  • Success
  • Retail
  • Mpw
  • Tech
  • Lifestyle
  • CEO Initiative
  • Asia
  • Politics
  • Conferences
  • Europe
  • Newsletters
  • Personal Finance
  • Environment
  • Magazine
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
  • Group Subscriptions
About Us
  • About Us
  • Editorial Calendar
  • Press Center
  • Work At Fortune
  • Diversity And Inclusion
  • Terms And Conditions
  • Site Map
  • About Us
  • Editorial Calendar
  • Press Center
  • Work At Fortune
  • Diversity And Inclusion
  • Terms And Conditions
  • Site Map
  • Facebook icon
  • Twitter icon
  • LinkedIn icon
  • Instagram icon
  • Pinterest icon

Latest in Health

Ivan Espinosa, chief executive officer of Nissan Motor Co
Successwork-life balance
The CEO of $8.5 billion Japanese car giant Nissan plays the drums in a band and hits the tennis courts to destress from the top job
By Emma BurleighApril 16, 2026
18 hours ago
wyle
CommentaryHealth
‘The Pitt’ reveals why healthcare desperately needs a new front door
By Jeremy MorganApril 16, 2026
21 hours ago
walt
Healthcyber
As a small business owner, I never expected to pay $100,000 protecting my business from ransomware
By Walter RowenApril 16, 2026
21 hours ago
health
CommentaryHealth Care Service
Two physicians on ending the waiting-room era: bring care home
By Benjamin Kornitzer and Bill FristApril 16, 2026
22 hours ago
bostrom
CommentaryMedical
Top New York surgeon: Americans have better data for choosing restaurants than surgeons. That has to change
By Mathias P. BostromApril 16, 2026
1 day ago
Germany already told its workers to ditch four-day weeks and work-life balance. Now the government wants to cut their pay for calling in sick, too
SuccessHealth
Germany already told its workers to ditch four-day weeks and work-life balance. Now the government wants to cut their pay for calling in sick, too
By Orianna Rosa RoyleApril 16, 2026
1 day ago

Most Popular

Jeff Bezos pledged $10 billion for climate change. With the 2030 clock ticking, his wife, Lauren Sánchez Bezos, is leading the charge to spend it
Environment
Jeff Bezos pledged $10 billion for climate change. With the 2030 clock ticking, his wife, Lauren Sánchez Bezos, is leading the charge to spend it
By Sydney LakeApril 15, 2026
2 days ago
A world going broke: IMF says America's $39 trillion national debt is actually a global problem—and AI may be the only rescue
Economy
A world going broke: IMF says America's $39 trillion national debt is actually a global problem—and AI may be the only rescue
By Nick LichtenbergApril 16, 2026
14 hours ago
Germany already told its workers to ditch four-day weeks and work-life balance. Now the government wants to cut their pay for calling in sick, too
Success
Germany already told its workers to ditch four-day weeks and work-life balance. Now the government wants to cut their pay for calling in sick, too
By Orianna Rosa RoyleApril 16, 2026
1 day ago
MacKenzie Scott is bypassing the Ivy League and rewriting the $79 billion higher ed playbook by giving to HBCUs and community colleges
Politics
MacKenzie Scott is bypassing the Ivy League and rewriting the $79 billion higher ed playbook by giving to HBCUs and community colleges
By Sydney LakeApril 16, 2026
18 hours ago
Current price of oil as of April 16, 2026
Personal Finance
Current price of oil as of April 16, 2026
By Joseph HostetlerApril 16, 2026
21 hours ago
Billionaire philanthropist MacKenzie Scott has donated again—a week after gifting millions to a college, she's just given $70 million to Meals on Wheels America
Success
Billionaire philanthropist MacKenzie Scott has donated again—a week after gifting millions to a college, she's just given $70 million to Meals on Wheels America
By Emma BurleighApril 13, 2026
4 days ago

© 2026 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.