• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia
Some Fortune Crypto pricing data is provided by Binance.
CompaniesCryptocurrency

From Wall Street to Uniswap: COO Mary-Catherine Lader sees the future of finance decentralized

By
Taylor Locke
Taylor Locke
Down Arrow Button Icon
By
Taylor Locke
Taylor Locke
Down Arrow Button Icon
October 17, 2022, 6:00 AM ET
Mary-Catherine Lader, COO of Uniswap Labs, in May 2022. For some, leaving Wall Street for the freewheeling world of DeFi would be a scary prospect. For Lader, it’s the place to be, even after the recent collapse of Terra.
Mary-Catherine Lader, COO of Uniswap Labs, in May 2022. For some, leaving Wall Street for the freewheeling world of DeFi would be a scary prospect. For Lader, it’s the place to be, even after the recent collapse of Terra. Natalie Keyssar—Bloomberg/Getty Images

Even with the market downturn and proliferation of hacks, Mary-Catherine Lader is among the most bullish on crypto—and has been for a while.

As chief operating officer at Uniswap Labs, the company behind the development of the largest decentralized exchange on Ethereum, Lader sees great value in decentralized protocols specifically. 

To her, not all products within the space are created equal, and that has been seen throughout the ongoing Crypto Winter. Following the Terra stablecoin collapse in May, countless centralized projects and lenders deteriorated, leaving investors at a loss and market sentiment very fearful. But, even still, “leading DeFi protocols like Uniswap are succeeding in these tough markets because the technology is fundamentally better than today’s rails,” Lader, known as “MC,” tells Fortune. 

Her case in point, at least when it comes to Uniswap: Despite an overall decline in crypto VC investment, Uniswap Labs just announced a $165 million Series B funding round, which values the company at $1.66 billion.

Aside from its fresh valuation, what differentiates Uniswap is the technology behind it, according to Lader. Unlike a centralized exchange, the Uniswap protocol operates as a fully noncustodial, permissionless, and self-executing entity through the use of smart contracts—or collections of code that run on a blockchain. 

“This technology can transform markets at a much greater scale,” said Lader, adding that, to her, protocols like Uniswap are “more transparent, and when done right, have reduced risk of operating errors, and lower barriers to access.”

This belief is what drove Lader to leave her Wall Street career behind, noting that “automated market-making and decentralized exchanges have huge potential in capital markets—well beyond its use in crypto today.”

‘Foundational technology’

Prior to Uniswap, Lader held several leadership positions at BlackRock, and at Goldman Sachs before that. Unlike most of her peers at the time, Lader took an interest in crypto very early, starting at a seminar she attended in 2011. From then, she kept blockchain technology in mind throughout her career.

One such time happened to be just two weeks into working at BlackRock. During a companywide town hall in 2015, CEO Larry Fink responded to a few questions from employees, Lader recalled. One question was about blockchain, and, according to Lader, Fink seemed to express that he viewed the technology as being mostly used for money laundering. (Fink has since expressed a different opinion.) 

Lader disagreed, and following the town hall she sent a memo to the head of her group detailing, in her opinion, the opportunity BlackRock would regrettably miss by dismissing the potential of the technology. Her memo was forwarded to the C-suite, Lader said, and to her surprise, it was well received. In return, Lader was given the lead on the firm’s first blockchain working group.

She went on to become COO of the company’s digital wealth business, and then global head of its sustainability business. All the while, “I was paying attention to crypto and felt like there would be a day that I worked in it full-time, but I wanted to make sure I joined a company that was at the application-level—with a product people could use, a fundamental, foundational technology—because I was always interested in where this technology touches real people’s lives.”

Lader felt she found this intersection at Uniswap, which, after nearly six years at BlackRock, she joined in June 2021.

Some might view this move—away from the stability of traditional finance and into very untraditional finance—as a leap of faith. Not Lader, who said it would’ve been “riskier” to stay put.

“One of the things I love about DeFi is that the technology has the potential to remake financial services, which means you have an opportunity to change where points of influence are. You have an opportunity to change and think differently about who you’re serving,” she said. “Most of today’s financial services have been designed by a somewhat homogeneous group of people.”

Obviously, DeFi is far from perfect, with countless issues surrounding crime, among other issues. But Lader sees potential in what the future of “safe and secure DeFi” may bring as it evolves, mentioning the technology’s transparency and the possibility for a new regulatory framework to come into place.

“DeFi teams have to prioritize security and user safety to grow,” she said.

Lader also notes that she has seen more TradFi interest—even after the Terra collapse—than ever before, signaling something potentially positive as the crypto market overall still struggles.

“The clearing that we’re going through now is piquing the interest of people in TradFi and in finance,” she said. “We’ve had a bunch of people reach out to us who just want to see how this works.”

Sign up for the Fortune Features email list so you don’t miss our biggest features, exclusive interviews, and investigations.

About the Author
By Taylor Locke
LinkedIn iconTwitter icon
See full bioRight Arrow Button Icon

Latest in Companies

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025

Most Popular

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Fortune Secondary Logo
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • World's Most Admired Companies
  • See All Rankings
  • Lists Calendar
Sections
  • Finance
  • Fortune Crypto
  • Features
  • Leadership
  • Health
  • Commentary
  • Success
  • Retail
  • Mpw
  • Tech
  • Lifestyle
  • CEO Initiative
  • Asia
  • Politics
  • Conferences
  • Europe
  • Newsletters
  • Personal Finance
  • Environment
  • Magazine
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
  • Group Subscriptions
About Us
  • About Us
  • Lists Calendar
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • About Us
  • Lists Calendar
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • Facebook icon
  • Twitter icon
  • LinkedIn icon
  • Instagram icon
  • Pinterest icon

Latest in Companies

Exclusive: Crypto venture firm CMT Digital raises $136 million for fourth fund
CompaniesVenture Capital
Exclusive: Crypto venture firm CMT Digital raises $136 million for fourth fund
By Ben WeissNovember 5, 2025
6 months ago
A Ferrari race car on a racetrack
CompaniesCryptocurrency
Ferrari to release crypto token to let wealthy fans take part in 499P auction
By Carlos GarciaNovember 3, 2025
6 months ago
Michael Saylor on stage at a Bitcoin conference.
CompaniesBitcoin
Michael Saylor boosts yield, says Strategy is at an ‘inflection point’
By David Pan, Judy Lagrou and BloombergOctober 30, 2025
6 months ago
Crypto founders are getting very rich, very fast—again
CompaniesCryptocurrency
Crypto founders are getting very rich, very fast—again
By Jeff John RobertsOctober 30, 2025
6 months ago
A Mastercard credit card peeking out from a pocket.
CompaniesMastercard
Exclusive: Mastercard poised to acquire crypto startup Zerohash for nearly $2 billion, sources say
By Ben Weiss and Leo SchwartzOctober 29, 2025
6 months ago
Three men stand in front a white backdrop.
CompaniesCryptocurrency
Exclusive: Startup Hercle raises $10 million to build out stablecoin-based global money transfers
By Carlos GarciaOctober 29, 2025
6 months ago

Most Popular

Elon Musk says saving for retirement is irrelevant because AI is going to create a world of abundance: 'It won't matter'
Future of Work
Elon Musk says saving for retirement is irrelevant because AI is going to create a world of abundance: 'It won't matter'
By Marco Quiroz-GutierrezApril 26, 2026
1 day ago
The U.S. military may have already used up half of its most expensive missiles, and it could take up to 4 years to rebuild its stockpiles
Politics
The U.S. military may have already used up half of its most expensive missiles, and it could take up to 4 years to rebuild its stockpiles
By Sasha RogelbergApril 24, 2026
3 days ago
Baby boomers have now 'gobbled up' nearly one-third of America's wealth share, and they're leaving Gen Z and millennials behind
Investing
Baby boomers have now 'gobbled up' nearly one-third of America's wealth share, and they're leaving Gen Z and millennials behind
By Sasha RogelbergApril 26, 2026
1 day ago
More than 90,000 tech workers have been laid off this year. But here’s why companies like Microsoft are offering voluntary buyouts instead
Big Tech
More than 90,000 tech workers have been laid off this year. But here’s why companies like Microsoft are offering voluntary buyouts instead
By Jacqueline MunisApril 26, 2026
1 day ago
'You feel radicalized': A Meta AI exec watched agents beat her top workers. Now she's built a nonprofit to help Gen Z find jobs before they disappear
Future of Work
'You feel radicalized': A Meta AI exec watched agents beat her top workers. Now she's built a nonprofit to help Gen Z find jobs before they disappear
By Jake AngeloApril 26, 2026
2 days ago
This CEO lived on canned soup and took just two days off for his daughter’s birth. Now he admits he lost sight of proper work-life balance
Success
This CEO lived on canned soup and took just two days off for his daughter’s birth. Now he admits he lost sight of proper work-life balance
By Preston ForeApril 25, 2026
3 days ago

© 2026 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.