• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia
NewslettersBrainstorm Health

Big Pharma’s Return on Investment Plummets to a Dismal 10-Year Low

By
Sy Mukherjee
Sy Mukherjee
Down Arrow Button Icon
By
Sy Mukherjee
Sy Mukherjee
Down Arrow Button Icon
December 18, 2019, 5:47 PM ET

This is the web version of Brainstorm Health Daily, Fortune’s daily newsletter on the top health care news. To get it delivered daily to your in-box, sign up here.

Good afternoon, readers.

I know we’re all supposed to be cheery going into the holidays, but I have some bad news: Legacy biopharma companies are still in a rut.

Or at least that’s what the experts over at Deloitte have to say in a new report finding that, for the top 12 biopharma companies, the return on investment for R&D has fallen to a dismal 1.8%.

That’s a decade-long low, and somehow even lower than last year’s 1.9% ROI (for comparison, the number stood at 10.1% in 2010).

The reasons are plentiful. Among them: A tougher regulatory environment and an ever-shifting R&D picture which now favors smaller, leaner firms over the giants of old. And even within that narrative, things are complicated, according to Deloitte’s Neil Lesser.

“The current model is not a sustainable one for success,” Lesser told Fortune in an interview.

But there are some plus points, too.

“Companies continue to see a lot of success with individualized and personalized medications,” said Lesser, adding that the model “hasn’t reached the volumes that the blockbuster model of multi-billion dollar drugs was based on.”

This ROI plummet may help explain, as we’ve previously explored, major drug companies’ insistence on hiking prices and engaging in expensive bolt-on acquisitions.

Read on for the day’s news.

Sy Mukherjee
sayak.mukherjee@fortune.com
@the_sy_guy

DIGITAL HEALTH

Medtronic nabs wearable startup Klue. Medical technology giant Medtronic is adding yet another digital health startup to its roster—Klue, which uses wearable technology in order to suss out certain gestures and behavioral health metrics, according to MobiHealthNews. This is meant to add to Medtronic's portfolio of products for diabetes management by examining and analyzing their eating habits. (MobiHealthNews)

INDICATIONS

FTC challenges Illumina's DNA deal. Shortly after clearing Roche's long-delayed acquisition of Spark Therapeutics, the FTC threw a buzzsaw into genomic sequencing giant Illumina's $1.2 billion quest to acquire PacBio, a rival DNA sequencing firm. Illumina strongly disagreed with the decision, which was based on monopoly concerns. (FierceBiotech)

REQUIRED READING

Unwrapping Christmas With Behavioral Economists, by Shannon Fitzgerald

Retailers Gave You Free Returns and You Ruined It, by Bloomberg

3 Signs You Won't Be Getting Promoted Anytime Soon, by Anne Fisher

Sign up for other Fortune newsletters.

About the Author
By Sy Mukherjee
See full bioRight Arrow Button Icon

Latest in Newsletters

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025

Most Popular

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Fortune Secondary Logo
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • Future 50
  • World’s Most Admired Companies
  • See All Rankings
Sections
  • Finance
  • Fortune Crypto
  • Features
  • Leadership
  • Health
  • Commentary
  • Success
  • Retail
  • Mpw
  • Tech
  • Lifestyle
  • CEO Initiative
  • Asia
  • Politics
  • Conferences
  • Europe
  • Newsletters
  • Personal Finance
  • Environment
  • Magazine
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
About Us
  • About Us
  • Editorial Calendar
  • Press Center
  • Work At Fortune
  • Diversity And Inclusion
  • Terms And Conditions
  • Site Map
Fortune Secondary Logo
  • About Us
  • Editorial Calendar
  • Press Center
  • Work At Fortune
  • Diversity And Inclusion
  • Terms And Conditions
  • Site Map
  • Facebook icon
  • Twitter icon
  • LinkedIn icon
  • Instagram icon
  • Pinterest icon

Latest in Newsletters

NewslettersMPW Daily
These are the female exec moves you need to know this week, from Xbox to Match Group’s board shakeup
By Emma HinchliffeFebruary 27, 2026
2 days ago
Intuit global headquarters in Mountain View, Calif.
NewslettersCFO Daily
Intuit’s CFO isn’t flinching at AI. He says it’s fueling the company’s next growth phase
By Sheryl EstradaFebruary 27, 2026
2 days ago
NewslettersCEO Daily
You’ve lost the CEO succession race. Here’s your multi-million dollar bonus
By Claire ZillmanFebruary 27, 2026
2 days ago
NewslettersTerm Sheet
Exclusive: Flux, backed by 8VC, raises $37 million to vibe code electronics
By Allie GarfinkleFebruary 27, 2026
3 days ago
NewslettersFortune Tech
Salesforce’s Marc Benioff does not fear the ‘SaaS-pocalypse’
By Alexei OreskovicFebruary 27, 2026
3 days ago
AIEye on AI
After months of quiet, Perplexity’s CEO steps into the OpenClaw moment
By Sharon GoldmanFebruary 26, 2026
3 days ago

Most Popular

placeholder alt text
Economy
Your grandparents are the reason the U.S. isn't in a recession right now. That won't last forever
By Eleanor PringleMarch 1, 2026
12 hours ago
placeholder alt text
AI
The week the AI scare turned real and America realized maybe it isn't ready for what's coming
By Nick LichtenbergFebruary 28, 2026
1 day ago
placeholder alt text
Success
Japanese companies are paying older workers to sit by a window and do nothing—while Western CEOs demand super-AI productivity just to keep your job
By Orianna Rosa RoyleFebruary 27, 2026
2 days ago
placeholder alt text
Middle East
Iran is now on 'death ground' amid existential threat from U.S. attacks and could 'go big' in retaliation, former NATO commander warns
By Jason MaFebruary 28, 2026
1 day ago
placeholder alt text
Success
Walmart exec says U.S. workforces needs to take inspiration from China where ‘5 year-olds are learning DeepSeek’
By Preston ForeFebruary 27, 2026
3 days ago
placeholder alt text
Middle East
Dubai’s worst nightmare unfolds as Iran strikes Gulf neighbors
By Dana Khraiche, Fiona MacDonald and BloombergFebruary 28, 2026
1 day ago

© 2026 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.