• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia

Trendingnow

1

U.S. Treasury has borrowed $155 billion every month of this fiscal year—and is now paying $24 billion a week in interest on its debts

2

Top Iranian officials admitted to the supreme leader that the U.S. naval blockade was crushing the economy, report says, as Trump eyes reimposing it

3

Billionaire MacKenzie Scott just donated $20 million to support America’s youth mental health, as a fifth of teens struggle with suicidal thoughts

1

U.S. Treasury has borrowed $155 billion every month of this fiscal year—and is now paying $24 billion a week in interest on its debts

2

Top Iranian officials admitted to the supreme leader that the U.S. naval blockade was crushing the economy, report says, as Trump eyes reimposing it

3

Billionaire MacKenzie Scott just donated $20 million to support America’s youth mental health, as a fifth of teens struggle with suicidal thoughts
dementia

Millions of Americans have ‘mild cognitive impairment’ and don’t know it, experts say. How the condition relates to Alzheimer’s—and what you can do about it

By
Erin Prater
Erin Prater
Down Arrow Button Icon
By
Erin Prater
Erin Prater
Down Arrow Button Icon
October 24, 2023, 10:00 PM ET
Nearly 7.5 million older Americans are likely living with mild cognitive impairment and unaware, researchers say. It’s a problem they’d like to solve for a couple of reasons: MCI isn’t a part of the normal aging process. And recently approved drugs may help preserve cognitive function in patients in the early stages of decline—but not in later stages.
Nearly 7.5 million older Americans are likely living with mild cognitive impairment and unaware, researchers say. It’s a problem they’d like to solve for a couple of reasons: MCI isn’t a part of the normal aging process. And recently approved drugs may help preserve cognitive function in patients in the early stages of decline—but not in later stages.Getty Images
Add Fortune on Google for similar content.

Nearly 7.5 million older Americans are predicted to have mild cognitive impairment (MCI)—a potential early sign of Alzheimer’s disease—but don’t know it.

Recommended Video

That’s according to new research from the University of Southern California, whose researchers have recently published two papers on the topic. 

In the first, published in Alzheimer’s Research & Therapy, researchers analyzed data from 40 million Medicare beneficiaries ages 65 and older and compared the number diagnosed with the condition to the number they would expect to be diagnosed. About 8 million Americans in that group likely have MCI, they predicted—about 13% of the country’s senior population or 1 in 7 seniors. But only 600,000 had received a proper medical diagnosis.

A second study, published Tuesday in The Journal of Prevention of Alzheimer’s Disease, also found that MCI is “vastly underdiagnosed,” with 99.9% of U.S. primary care clinicians not sufficiently catching cases. Only about 8% of U.S. residents with the condition have been diagnosed, researchers concluded after crunching the numbers on data from nearly 250,000 U.S. doctors.

Nearly 7.5 million older Americans are likely living with MCI unaware, researchers say. It’s a problem they’d like to solve for a couple of reasons: Contrary to popular belief, MCI isn’t a part of the normal aging process. And recently approved drugs may help preserve cognitive function in patients in the early stages of decline—but not in later stages.

While detection of the condition is generally poor in the U.S., it’s even worse among patients from historically disadvantaged groups—including Black and Hispanic Americans, and those with less education. Not only that, but the risk of developing the condition is also higher in such groups as well, researchers say.

And that’s a tragedy. Because in cases of MCI caused by Alzheimer’s disease, “the earlier you treat, the better the outcomes,” Dr. Soeren Mattke, director of the Center for Improving Chronic Illness Care at the University of Southern California and a co-author on both studies, tells Fortune. “This means even though the disease may be slowly progressing, every day counts.”

What to do if you’re concerned about MCI

Those who have memory concerns—who sense they’re becoming more forgetful, having difficulty keeping track of time, and/or getting lost more often—should bring the subject up to their primary care provider. Those who are a caregiver of someone experiencing such changes should schedule an appointment for their loved one and attend, Mattke says.

Primary care providers can perform a quick assessment and decide whether you or your loved one should be referred to a specialist, like a neurologist or geriatrician, who can perform more in-depth cognitive testing. 

It takes a bit of preparation for a primary care provider to perform a preliminary cognitive assessment. So if you’re seeking one, let your doctor’s office know when you schedule instead of springing it on them at the appointment, Mattke recommends.

If you’re middle-aged or younger, you likely don’t have MCI, which is “very aging-related,” he adds. The number of those in those in their 50s with MCI “is still pretty low.” It’s generally found among those 65 and older.

MCI’s connection to Alzheimer’s disease

MCI is a symptom set, and the cause isn’t always Alzheimer’s disease, Mattke said. Still, about half of cases of MCI are due to early Alzheimer’s. And now that there are U.S. Food and Drug Administration-approved treatments to slow disease progression, it’s more crucial than ever to see a doctor if you’re concerned.

Before this summer, when lecanemab (Leqembi) was approved by the FDA, doctors often wouldn’t perform the physical tests needed to diagnose early Alzheimer’s—like a PET scan or cerebral spinal fluid analysis—on patients with MCI because even if they had the disease, doctors couldn’t slow the progression.

Now that the drug has been approved, patients who were previously diagnosed with MCI should return to their doctors and ask if tests for Alzheimer’s should be run, with the goal of starting treatment, if appropriate, Mattke recommends.

Lecanemab is like “Drano for the brain” and involves an IV infusion performed at a medical center—perhaps as frequently as every two weeks, he said. While it can’t reverse the condition—lost brain cells don’t regenerate—it can clear amyloid plaques and tau tangles from the brain, slowing the progression of the disease.

While the treatment isn’t a cure, it may allow some Alzheimer’s patients to “live out their biological lifespan and still recognize their spouse when they go to bed in the evening.”

It’s incredibly important that patients facing a potential Alzheimer’s disease diagnosis realize that “we have a treatment,” Mattke said—but “time is not on your side.”

About the Author
By Erin Prater
See full bioRight Arrow Button Icon
Add Fortune on Google for similar content.

Latest in

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025

Most Popular

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Fortune Secondary Logo
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • World's Most Admired Companies
  • See All Rankings
  • Lists Calendar
Sections
  • Finance
  • Fortune Crypto
  • Features
  • Leadership
  • Health
  • Commentary
  • Success
  • Retail
  • Mpw
  • Tech
  • Lifestyle
  • CEO Initiative
  • Asia
  • Politics
  • Conferences
  • Europe
  • Newsletters
  • Personal Finance
  • Environment
  • Magazine
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
  • Group Subscriptions
About Us
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • Facebook icon
  • Twitter icon
  • LinkedIn icon
  • Instagram icon
  • Pinterest icon

Latest in

How SK Hynix just pulled off the second-largest U.S. share sale by quietly powering the AI boom
AsiaIPOs
How SK Hynix just pulled off the second-largest U.S. share sale by quietly powering the AI boom
By Nicholas GordonJuly 11, 2026
1 hour ago
A $5 hair tie, a sold-out dress, cake and a fast-food order: How fans chase closeness to Erling Haaland, Taylor Swift and other celebrities
Arts & EntertainmentWorld Cup
A $5 hair tie, a sold-out dress, cake and a fast-food order: How fans chase closeness to Erling Haaland, Taylor Swift and other celebrities
By Mia OsmonbekovJuly 11, 2026
2 hours ago
Why the 2026 IPO boom is about to broaden beyond AI mega-deals
InvestingFinance
Why the 2026 IPO boom is about to broaden beyond AI mega-deals
By Sheryl EstradaJuly 11, 2026
2 hours ago
Ulta is betting $400 million that an NYC megastore will help it compete with Sephora—and that flagships still work
C-SuiteRetail
Ulta is betting $400 million that an NYC megastore will help it compete with Sephora—and that flagships still work
By Phil WahbaJuly 11, 2026
3 hours ago
Apple accuses OpenAI, and former design star Jony Ive’s io Products firm, of stealing hardware trade secrets in blockbuster lawsuit
Big TechApple
Apple accuses OpenAI, and former design star Jony Ive’s io Products firm, of stealing hardware trade secrets in blockbuster lawsuit
By Sebastian HerreraJuly 10, 2026
11 hours ago
OpenAI CEO Sam Altman sitting next to U.S. President Donald Trump at the G7 Meeting in Evian, France.
AIOpenAI
OpenAI’s latest AI model likely has similar cyber vulnerabilities to one that led to U.S. export controls on Anthropic’s Fable, British agency says
By Emily Forlini and Jeremy KahnJuly 10, 2026
11 hours ago

Most Popular

U.S. Treasury has borrowed $155 billion every month of this fiscal year—and is now paying $24 billion a week in interest on its debts
Economy
U.S. Treasury has borrowed $155 billion every month of this fiscal year—and is now paying $24 billion a week in interest on its debts
By Eleanor PringleJuly 10, 2026
24 hours ago
Top Iranian officials admitted to the supreme leader that the U.S. naval blockade was crushing the economy, report says, as Trump eyes reimposing it
Middle East
Top Iranian officials admitted to the supreme leader that the U.S. naval blockade was crushing the economy, report says, as Trump eyes reimposing it
By Jason MaJuly 10, 2026
18 hours ago
Billionaire MacKenzie Scott just donated $20 million to support America’s youth mental health, as a fifth of teens struggle with suicidal thoughts
Success
Billionaire MacKenzie Scott just donated $20 million to support America’s youth mental health, as a fifth of teens struggle with suicidal thoughts
By Emma BurleighJuly 9, 2026
2 days ago
Farm groups saved Bayer in court over RoundUp cancer claims. Five days later, Bayer called for tariffs on the ingredient farmers rely on
Economy
Farm groups saved Bayer in court over RoundUp cancer claims. Five days later, Bayer called for tariffs on the ingredient farmers rely on
By Mia OsmonbekovJuly 9, 2026
2 days ago
Wyoming officials say Meta’s 715,000-square-foot data center is responsible for contaminating its water system with a rare bacterium
Environment
Wyoming officials say Meta’s 715,000-square-foot data center is responsible for contaminating its water system with a rare bacterium
By Sasha RogelbergJuly 10, 2026
19 hours ago
Self-made multimillionaire says Canadians 'give no money away' compared with Americans—research shows U.S. giving is more than twice as high
Success
Self-made multimillionaire says Canadians 'give no money away' compared with Americans—research shows U.S. giving is more than twice as high
By Preston ForeJuly 9, 2026
2 days ago

© 2026 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.