5 Best NAD supplements of 2025: Expert Reviewed and Tested

We worked with a certified nutrition coach to evaluate and select the top NAD+ supplements of 2025, providing a list of clinically backed and third-party tested options for beginners and advanced users of NAD+ alike.

Best NAD+ Supplements of 2025

• Best NAD+ Supplement Overall: Nutricost NAD+
• Best NAD+ Supplement for Men: Doublewood Supplements NAD+
• Best NAD+ Supplement for Women: Ageless Rx
• Best NAD+ Supplement for Energy: Innerbody Labs NAD+ Support
• Best Powder NAD+ Supplement: IM8 Daily Ultimate Longevity

Why Trust Fortune

Our team of expert testers has tried hundreds of the most popular supplements on the market today, using our comprehensive supplement testing methodology to find the best products for all folks.

Best NAD+ Supplements Comparison Table

Best NAD+ Supplement Overall: Nutricost NAD+

Our Thoughts on Nutricost NAD+

Nutricost NAD+ is our pick for the best overall NAD+ supplement because it has a straightforward, minimalist formula and effective dosage of 1,000 milligrams per serving. It’s also vegan and gluten-free. And it’s manufactured in an NSF Certified, GMP compliant, and FDA registered facility. Plus, each bottle contains 60 servings, so you can shop less frequently.

Pete tested Nutricost’s NAD+ supplement, rating it a 5 out of 5 for his first impression. “It’s a white plastic bottle with a blue screw top lid that opens and closes easily. The label has a matte finish that’s easy to read. The container is small enough to be travel friendly,” he said. The directions were simple and easy to follow, and Pete rated them a 5 out of 5 in this category. 

Unfortunately, he did have to rate the swallowability of Nutricost’s NAD+ as a 3 out of 5. The capsules are standard size, Pete said, about one inch in length and one centimeter in diameter and are clear with a white powder inside. The serving size is two capsules per day but they weren’t the most convenient to swallow. That said, Pete did find the capsules to be tasteless and odorless when testing them, which was a plus. 

After trying these NAD+ supplements a few times, he didn’t experience any side effects, rating it a 5 out of 5 in this category. Though, he didn’t necessarily feel immediate benefits either. 

Our team also loved the dosage this product provides. Nutricost’s NAD provides 1,000 milligrams of NAD per serving, which is large compared to other options. “This is a higher dosage than most NAD supplements on the market,” Pete said. “They’re typically between 250 and 500 milligrams per serving.”

Best NAD+ Supplement for Men: Doublewood Supplements NAD+

Our Thoughts on Doublewood Supplements NAD+

Doublewood Supplements NAD+ is our pick for the best NAD+ supplement for men not because it’s a gender-specific formula, but because its purity, third-party testing, and minimalist design appeal to those who value transparency and simplicity. Men may particularly appreciate its straightforward composition—high-quality NAD+ with no unnecessary fillers—making it a quality daily choice for supporting energy metabolism, endurance, and cognitive health.

Doublewood’s NAD comes in a small white plastic container with a screw lid top that’s easy to open and close. Pete tested this NAD+ supplement, rating his first impressions a 5 out of 5. “The label isn’t flashy, it’s simple and easy to read. It’s something I would expect to see in a chiropractic office, not a GNC,” he said. The directions were easy to understand and follow; Pete rated them a 5 out of 5. 

The capsules are clear with white powder inside. “They’re smaller than a typical capsule, about three-quarters of an inch in length and one centimeter in diameter,” he said. Pete rated swallowability a 3 out of 5. The capsules were tasteless and odorless. 

Of the overall 500 milligrams dose of NAD+, Pete says, “This is an effective dose based on clinical research, in terms of increasing the amount of NAD+ in the blood.” That said, this isn’t the highest dose you can find in an NAD supplement. If you’re looking for more, we recommend Nutricost’s NAD.

Best NAD+ Supplement for Women: Ageless Rx

Our Thoughts on Ageless Rx

AgelessRx NAD+ Face Cream is our pick for the best NAD+ supplement for women because it delivers pure, pharmaceutical-grade NAD+ to the skin, not just niacinamide or NMN derivatives. It doesn’t include any superfluous ingredients, is vegan and cruelty-free, and is compounded fresh by a certified pharmacy each month for potency and purity. 

While this isn’t necessarily a gender-specific product, women’s skincare routines tend to be a bit more extensive than men’s, so we think women may want to try a topical NAD+ supplement. Regardless of gender, though, this is our best NAD+ supplement for skin and can be used by anyone.

Gwen tested this face cream, rating it a 5 out of 5 for her first impression. The container is simple, and has a prescription label like you would find on a pill bottle. “It’s a simple pump top, which I like because I don’t enjoy digging my nails into a tub of cream,” she said. “The instructions are simple and printed on the front of the prescription,” Gwen said, rating the instructions a 5 out of 5 for ease of understanding and following. “All you do is apply a pea-sized amount to your whole face before your skincare routine in the evening.”

She enjoyed how the cream felt on her skin. “The texture was really smooth,” she said. “I like that it wasn’t overly thick, either. It was just a really light layer on my skin and it absorbed pretty quickly,” Gwen said. “It didn’t feel oily or greasy.” Unfortunately, she didn’t love that you have to keep the cream in the fridge. Unless you have a skincare fridge in your bathroom, it can be inconvenient to walk all the way back to the kitchen after washing your face before bed.

“The cost is really pricey for a small bottle,” Gwen noted, rating it a 2 out of 5 for price. “I’m not sure how effective the treatment is. It’s a longevity-focused product, so it’s hard to see any changes after just a few uses,” she said. “I’m also someone who gets Botox done and don’t have many fine lines, so it may work better for folks who have a treatment focus area.” That said, Gwen felt that AgelessRx NAD+ Facial Cream had a retinol-like effect; she felt that it helped smooth and even her skin tone a bit. 

If you’re someone who has sensitive skin or any preexisting skin conditions, we recommend chatting with your dermatologist before trying this product. “I’ve worked with a lot of dermatologists in the past,” Gwen said. “NAD may help with your skin health, and it probably won’t hurt to try. But I highly recommend buying a good SPF, too.” 

Best NAD+ Supplement for Energy: Innerbody Labs NAD+ Support

Our Thoughts on Innerbody Labs NAD+ Support

Innerbody Labs NAD+ Support is our pick for the best NAD+ Supplement for Energy because it helps target cellular metabolism from multiple angles. By combining NMN (700 milligrams) and NR (400 milligrams), it fuels the body’s NAD+ pathways that power cellular energy. Research shows that boosting NAD+ helps activate sirtuins and improve mitochondrial function, essential for both energy and endurance.

Gwen tested Innerbody’s NAD+ Support, rating it a 5 out of 5 for her first impression. “The container for this product is incredibly sleek and simple,” she said. “I love the clean white background and the pops of red. I also like that it’s not overly cluttered with information on the front.” Gwen also noted that the supplement facts are clear and easy to understand, rating it a 5 out of 5 for ease of understanding and following the directions.

She rated the swallowability a 3 out of 5: “The capsule is a standard size, I wouldn’t say that it’s too large or difficult to swallow,” Gwen said. “The serving size is three capsules, though. This isn’t problematic for me because I’m used to taking a bunch of supplements, but some folks may need to take the pills individually,” she said. If you prefer fewer pills per serving, we recommend you go with Nutricost NAD.

Gwen didn’t notice any taste with this product. “It doesn’t taste chalky or have any kind of aftertaste that I noticed,” she said, rating it a 5 out of 5 for taste. She didn’t experience any side effects or digestive upset, either.

Best Powder NAD+ Supplement: IM8 Daily Ultimate Longevity

Our Thoughts on IM8 Daily Ultimate Longevity

Though this isn’t technically the best liquid NAD+ supplement, IM8 Daily Ultimate Longevity’s powder sachets are designed to be mixed with water, creating a delicious and easy-to-consume NAD+ beverage that appeals to folks seeking a flexible, highly absorbable alternative to capsules or tablets. We chose IM8 for its blend of 300 milligrams of pharmaceutical-grade NMN with supportive ingredients to boost NAD+ even further.

Pete tested IM8’s Daily Ultimate Longevity, rating his first impressions of the product a 5 out of 5. The supplement comes in individual stick packs. “The box looks nice, it’s an orange to red gradient and the white text is easy to read,” he said. The stick packs have a foil finish and also have the same color gradient. “The packs were easy to rip open, and very travel-friendly,” Pete said. He rated the instructions a 5 out of 5 as well, noting that they were easy to read and follow.

Mixability was also rated as a 5 out of 5: “I emptied the stick pack into my shaker bottle filled with ten ounces of water and shook for 60 seconds,” Pete said. “The product fully dissolved in that time, and there were no clumps or gritty texture—it dissolved fully.” 

Pete rated the taste as a 5, and sweetness at a moderate level of 3. He tried the acai berry pomegranate flavor: “The flavor is berry forward, with a slight hint of the pomegranate,” Pete said. “They nailed the sweetness level on this one, it’s not too sweet and feels very refreshing. The product wasn’t foamy at all and it was fully dissolved with no grainy texture,” he said.

“This area of anti-aging supplementation is still relatively new, and more clinical data is necessary, especially before spending $150 on a supplement,” Pete advises. “We really need long-term human outcome data to make any real claims about these types of products.” That said, “If you have the money, there don’t seem to be any downsides to taking these types of supplements,” Pete observed.

What are NAD+ Supplements?

Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme present in every living cell, essential for converting nutrients into usable energy (ATP) and maintaining proper cellular function. It plays critical roles in DNA repair, gene expression, metabolism, and cell signaling, all of which are central to energy production and longevity. However, NAD+ levels naturally decline with age, oxidative stress, and unhealthy lifestyle factors, leading to decreased metabolic and cognitive function and faster cellular aging. 

NAD+ supplements are formulated to help replenish these declining levels. Most products do not contain NAD+ itself but precursor molecules (like nicotinamide riboside [NR], nicotinamide mononucleotide [NMN], or niacin) that are converted into NAD+ within the body. This process boosts cellular NAD+ and enhances mitochondrial energy production. By restoring NAD+ balance, these supplements may support sustained energy, improved focus, and more efficient cellular repair mechanisms.

What do NAD+ Supplements Do in the Body?

NAD+ supplements work at the cellular level of your body to restore energy, repair tissues, and improve metabolic resilience. While not a cure-all, maintaining healthy NAD+ levels may contribute to greater vitality and longevity through reduced oxidative stress.

How We Tested and Selected the Best NAD+ Supplements

We tested and evaluated NAD+ supplements and scored them on a scale of 1-5 for factors such as first impressions, easy-to-follow directions, swallowability, side effects, and value. Our testers evaluate the products based on their own individual experiences and preferences. We then review their testing feedback and data to share our findings and recommendations with you.

Formula

When selecting and testing NAD+ supplements, we worked with a certified nutrition coach to ensure each formula meets the highest standards for efficacy and safety. The evaluation process focuses on clinically supported dosages that reflect current research, seeking NAD+ products that deliver the optimal amounts shown in peer-reviewed studies. Ingredient quality and transparency are top priorities, and we favored NAD+ supplements made in GMP-certified facilities, with third-party testing, and free of unnecessary additives.

Taste and Texture

Flavor is a big part of our testing process. We asked our testers to provide feedback on the taste, aftertaste, and swallowability of the NAD+ supplements.

Form

Serving sizes for NAD+ supplements range from a single capsule to multiple pills. Whenever possible, we chose NAD+ products that required fewer capsules per serving for added convenience. We also tested NAD+ supplements in various forms, such as a mixable powder and face cream, for folks who like to vary the way they ingest the supplement.

Third-Party Testing

We selected NAD+ supplements that have been verified through third-party testing for safety, purity, and label accuracy. This process also screens for harmful substances like heavy metals and pesticides.

For athletes, third-party testing is crucial to confirm there are no banned substances—products should be sport certified. Since the FDA does not regulate supplements, independent verification is essential for safety, accuracy, and consumer trust.

Value

When considering value, we place a higher value on brands that source their ingredients in America and have certifications, such as Informed Choice.

How to Find the Best NAD+ Supplement for You

NAD+ supplement needs vary based on your age, lifestyle, and any specific health goals you may have related to energy or cellular support.

Consider these factors when choosing the most suitable NAD+ supplement for you.

Your Body’s Needs

NAD+ supplements can play a helpful role in supporting energy metabolism and cellular repair, but they aren’t essential for everyone. Think of them as an optional boost to complement healthy habits—like proper nutrition, exercise, and good sleep—rather than a necessary cornerstone of wellness.

Formula

Everyone has different dietary needs, so it’s worth checking the ingredient list before purchasing. Some NAD+ formulas include added vitamins, collagen, or supportive compounds, which might align differently with various diet types or fitness goals. If a supplement includes additional nutrients, compare them with your recommended daily values (RDVs) to avoid excess intake. Choosing a formula that complements your existing nutrition can help you make the most of your NAD+ supplement.

Cost

NAD+ supplements are typically taken daily, and can be pricey, so consider your budget before purchasing. Cleaner formulations, meaning those without artificial sweeteners or additives, may cost more because of their higher quality and ingredient sourcing.

Third-Party Testing

Because the FDA does not regulate supplements, third-party testing provides independent verification of a NAD+ supplement’s safety, purity, and label accuracy. This process protects against risks like mislabeling, contamination, or banned substances, giving you confidence in the products you choose. Independent testing is crucial for ensuring both product quality and safety.

Benefits of NAD+ Supplements

Much like a NMN supplement or collagen powder, NAD+ supplements can offer an array of health benefits, potentially helping your longevity and metabolic health. Here are a few:

• Enhanced energy production: NAD+ helps to combat fatigue and improve endurance at the cellular level by converting nutrients into usable energy
• Improved cognitive and cellular health: NAD+ supports brain health by protecting neurons from oxidative stress and inflammation, promoting better memory, mental clarity, and overall cognitive function
• Metabolic and anti-aging support: Maintaining optimal NAD+ levels has been linked to better metabolic regulation, improved insulin sensitivity, reduced inflammation, and protection against age-related decline

How to Take NAD+ Supplements

Most NAD+ supplements come in capsule, tablet, powder, or even liquid form; they are typically taken daily. For best results: 

• Take NAD+ supplements in the morning, preferably with or after breakfast for optimal absorption and energy support throughout the day
• Start with the lowest recommended dose and increase gradually
• Consistency is key; regular daily use maintains steady NAD+ levels
• NAD+ supplements can be paired with ingredients like resveratrol or TMG for synergistic support, but we recommend talking with your doctor regarding combinations and medication interactions before starting or combining supplements

How Much NAD Should You Take Daily?

Clinical research indicates that the most effective daily dosage for NAD+ precursors (such as nicotinamide riboside or nicotinamide mononucleotide) typically falls within the range of 250 milligrams to 500 milligrams per day for most adults, though some studies safely use up to 1,000mg per day for more robust increases in NAD+ levels.

Are There Any Risks of Taking NAD+ Supplements?

NAD+ supplements are generally considered safe and well-tolerated for most people, with minor side effects such as nausea, headache, mild digestive upset, flushing, or fatigue possible. There are some risks: long-term safety of taking an NAD+ supplement is still being studied, especially for high doses or prolonged periods of use. NAD+ supplements may interact with medications or other health conditions, so we recommend speaking with your doctor before starting an NAD+ product.

Frequently Asked Questions

Which NAD+ supplement is best?

Nutricost NAD+ is our pick for the best overall NAD+ supplement because it has a straightforward, minimalist formula and effective dosage of 1,000 mg per serving. It’s also vegan and gluten-free. And it’s manufactured in a NSF Certified, GMP compliant, and FDA registered facility. Plus, each bottle contains 60 servings, so you can shop less frequently.

What is the most effective form of NAD+?

Precursors to NAD+, such as NMN and NR, are an effective form of NAD+. Taking NAD+ supplements, whether in capsule, powder, or another form, is also effective at maintaining the level of NAD+ in your body when taken consistently.

Is NAD just vitamin B3?

No, NAD+ is not Vitamin B3, though the two are similar. Nicotinamide riboside, a precursor to NAD+, is a form of Vitamin B3.