Against the backdrop of America’s 250 anniversary, Fortune is convening leaders from Fortune 500 companies alongside innovative startup founders, policymakers, and thought leaders shaping the future of business.

On Nov. 16-17 in Detroit—the city that powered America’s first industrial age—we gather to ask: What will the next century of American ingenuity require?

As recent economic shocks have accelerated the pace of creative destruction, U.S. companies face intensifying competition from China and other emerging economies, often finding themselves outpaced on cost, scale, and speed of innovation. In response, business leaders are rebuilding their capacity to withstand disruption and charting a path toward a new era of industrialization powered by technological ingenuity. The decisions made now will determine which institutions endure—and which become cautionary tales.

These will be candid conversations led by Fortune’s journalists, examining the role of capitalism and competition in America—from advancing technology and creating jobs to revitalizing communities and moving markets. Across mainstage conversations and intimate, function-specific discussions, attendees will engage directly with peers and leave better equipped to lead in a period of profound transformation.

More information about the Forum and the list of 2026 speakers can be found here.