In an interview with conservative commentator Hugh Hewitt, Trump said the first American-born pontiff is helping Iran and also making the world less safe with his comments about the importance of not treating immigrants with disrespect.

“The pope would rather talk about the fact that it’s OK for Iran to have a nuclear weapon,” Trump said in the interview on Monday. “And I don’t think that’s very good. I think he’s endangering a lot of Catholics and a lot of people.”

The pope, however, has not said Iran should obtain nuclear weapons. He’s called for more peace talks, and criticized war with Iran generally and Trump’s specific threats of mass civilian strikes. The pope also has emphasized that he’s reflecting biblical and church teachings, not speaking as a political rival to Trump.

Leo responded to Trump’s latest criticism by calling out the U.S. president’s misrepresentation of his views. Speaking to reporters Tuesday, the pope said the Catholic Church “for years has spoken out against all nuclear weapons, so there is no doubt there.”

He also doubled down on his insistence that his call for peace and dialogue in the U.S-Israeli war in Iran is biblically inspired.

“The mission of the church is to preach the Gospel, to preach peace. If someone wants to criticize me for announcing the Gospel, let him do it with the truth,” Leo said.

Rubio downplays the rift over Iran

For his part, Rubio, a practicing Catholic, said Trump’s recent criticisms were rooted in his opposition to Iran potentially obtaining a nuclear weapon, which he said could be used against millions of Catholics and other Christians. Rubio said the whole world should be opposed to that.

Trump “doesn’t understand why anybody — leave aside the pope — the president and I, for that matter, I think most people, I cannot understand why anyone would think that it’s a good idea for Iran to ever have a nuclear weapon,” Rubio told reporters at the White House.

Still, Trump’s latest comments may make Rubio’s task more difficult when he sees the pontiff on Thursday. Rubio has often been called on to tone down or explain Trump’s harsh rhetoric as it relates to Europe, NATO and the Middle East, but the president’s dispute with the pope has domestic political implications in the U.S. with midterm congressional elections approaching.

Trump lashed out at Leo on social media last month, saying the pope was soft on crime and terrorism for comments about the administration’s immigration policies and deportations as well as the Iran war. Leo then said God doesn’t listen to the prayers of those who wage war.

Later, Trump posted a social media image likening himself to Jesus Christ, which he then deleted after backlash. He has refused to apologize to Leo and has sought to explain away the social media post by saying he thought the image was of him as a doctor.

The tension spills over into Italian politics

Italian Prime Minister Giorgia Meloni, a long-time Trump ally, has taken exception to Trump’s comments about the pope.

Trump in return criticized her as his ire against NATO allies expands over what he sees as a lack of support for the Iran war — most recently with the Pentagon planning to pull thousands of troops out of Germany in the coming months.

In response to Trump’s latest comments criticizing the pope, Italian Foreign Minister Antonio Tajani said in a social media post that they were “neither acceptable nor helpful to the cause of peace.”

“I reaffirm my support for every action and word of Pope Leo; his words are a testament to dialogue, the value of human life, and freedom. This is a vision shared by our government, which is committed through diplomacy to ensuring stability and peace in all areas where conflicts exist,” Tajani wrote.

Rubio, who after this trip will have visited Italy or the Vatican at least three times in the past year, is expected to meet with Meloni and Tajani on Friday.

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Winfield reported from Rome. Bill Barrow in Atlanta contributed to this report.