• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia
PoliticsIran

Israel targets Iran’s Defense Ministry headquarters as Tehran unleashes deadly missile strike

By
Jon Gambrell
Jon Gambrell
,
Melanie Lidman
Melanie Lidman
,
Julia Frankel
Julia Frankel
, and
The Associated Press
The Associated Press
Down Arrow Button Icon
By
Jon Gambrell
Jon Gambrell
,
Melanie Lidman
Melanie Lidman
,
Julia Frankel
Julia Frankel
, and
The Associated Press
The Associated Press
Down Arrow Button Icon
June 15, 2025, 10:36 AM ET
Fire and smoke rise into the night sky after an Israeli attack on the Shahran oil depot.
Fire and smoke rise into the sky after an Israeli attack on the Shahran oil depot on Sunday.Getty Images

Israel launched an expanded assault on Iran on Sunday, targeting its energy industry and Defense Ministry headquarters, while Tehran unleashed a fresh barrage of deadly strikes.

Recommended Video

The simultaneous attacks represented the latest burst of violence since a surprise offensive by Israel two days earlier aimed at decimating Tehran’s rapidly advancing nuclear program.

New explosions boomed across Tehran as Iranian missiles entered Israel’s skies in attacks that Israeli emergency officials said caused deaths around the country, including four in an apartment building in the Galilee region. A strike in central Israel killed an 80-year-old woman, a 69-year-old woman and a 10-year-old boy, officials said.

Casualty figures weren’t immediately available in Iran, where Israel targeted its Defense Ministry headquarters in Tehran as well as sites that it alleged were associated with the country’s nuclear program. Iran’s paramilitary Revolutionary Guard claimed that Iranian missiles targeted fuel production facilities for Israeli fighter jets, something not acknowledged by Israel.

Amid the continued conflict, planned negotiations between Iran and the United States over Tehran’s nuclear program were cancelled, throwing into question when and how an end to the fighting could come.

“Tehran is burning,” Israeli Defense Minister Israel Katz said on social media.

Both Israel’s military and Iran state television announced the latest round of Iranian missiles as explosions were heard near midnight, while the Israeli security cabinet met.

Israel’s ongoing strikes across Iran have left the country’s surviving leadership with the difficult decision of whether to plunge deeper into conflict with Israel’s more powerful forces or seek a diplomatic route.

Urgent calls to deescalate

World leaders made urgent calls to deescalate and avoid all-out war. The attack on nuclear sites set a “dangerous precedent,” China’s foreign minister said. The region is already on edge as Israel makes a new push to eliminate the Iranian-backed militant group Hamas in Gaza after 20 months of fighting.

Israel — widely believed to be the only nuclear-armed state in the Middle East — said its hundreds of strikes on Iran over the past two days have killed a number of top generals, nine senior scientists and experts involved in Iran’s nuclear program. Iran’s U.N. ambassador has said 78 people were killed and more than 320 wounded.

U.S. intelligence agencies and the International Atomic Energy Agency have repeatedly said Iran was not pursuing a nuclear weapon before Israel unleashed its campaign of airstrikes targeting Iran beginning Friday. But Iran’s uranium enrichment has reached near weapons-grade levels, and on Thursday the U.N.’s atomic watchdog censured Iran for not complying with obligations meant to prevent it from developing a nuclear weapon.

Prime Minister Benjamin Netanyahu, who has made the destruction of Iran’s nuclear program his top priority, said Israel’s strikes so far are “nothing compared to what they will feel under the sway of our forces in the coming days.”

In what could be another escalation if confirmed, semiofficial Iranian news agencies reported an Israeli drone struck and caused a “strong explosion” at an Iranian natural-gas processing plant. It would be the first Israeli attack on Iran’s oil and natural gas industry. Israel’s military did not immediately comment.

The extent of damage at the South Pars natural gas field was not immediately clear. Such sites have air defense systems around them, which Israel has been targeting.

Iran calls nuclear talks ‘unjustifiable’

The sixth round of U.S.-Iran indirect talks on Sunday over Iran ’s nuclear program will not take place, mediator Oman said. “We remain committed to talks and hope the Iranians will come to the table soon,” said a senior U.S. official, speaking on condition of anonymity to discuss diplomacy.

Iran’s top diplomat said Saturday the nuclear talks were “unjustifiable” after Israel’s strikes. Abbas Araghchi’s comments came during a call with Kaja Kallas, the European Union’s top diplomat.

The Israeli airstrikes were the “result of the direct support by Washington,” Araghchi said in a statement carried by the state-run IRNA news agency. The U.S. has said it isn’t part of the strikes.

On Friday, U.S. President Donald Trump urged Iran to reach a deal with the U.S. on its nuclear program, adding that “Iran must make a deal, before there is nothing left.”

US helps to shoot down Iranian missiles

Iran launched its first waves of missiles at Israel late Friday and early Saturday. The attacks killed at least three people and wounded 174, two of them seriously, Israel said. The military said seven soldiers were lightly wounded when a missile hit central Israel, without specifying where.

U.S. ground-based air defense systems in the region were helping to shoot down Iranian missiles, said a U.S. official who spoke on condition of anonymity to discuss the measures.

Israel’s main international airport said it will remain closed until further notice.

First responders were looking for survivors and clearing the remnants of a missile that fell on a neighborhood outside of Tel Aviv early Sunday morning.

An Associated Press reporter saw streets lined with damaged and destroyed buildings, bombed out cars and shards of glass.

Responders used a drone at points to look for survivors in some of the areas that were too hard to access. Some people were fleeing the area with their belongings in suitcases.

‘More than a few weeks’ to repair nuclear facilities

Israel attacked Iran’s main nuclear enrichment facility in Natanz. Satellite photos analyzed by AP show extensive damage there. The images shot Saturday by Planet Labs PBC show multiple buildings damaged or destroyed. The structures hit include buildings identified by experts as supplying power to the facility.

U.N. nuclear chief Rafael Grossi told the Security Council that the above-ground section of the Natanz facility was destroyed. The main centrifuge facility underground did not appear to have been hit, but the loss of power could have damaged infrastructure there, he said.

Israel said it also struck a nuclear research facility in Isfahan, including “infrastructure for enriched uranium conversion,” and said it destroyed dozens of radar installations and surface-to-air missile launchers in western Iran. Iran confirmed the strike at Isfahan.

The International Atomic Energy Agency said four “critical buildings” at the Isfahan site were damaged, including its uranium conversion facility. “As in Natanz, no increase in off-site radiation expected,” it added.

An Israeli military official, speaking on condition of anonymity in line with official procedures, said that according to the army’s initial assessment “it will take much more than a few weeks” for Iran to repair the damage to the Natanz and Isfahan nuclear sites. The official said the army had “concrete intelligence that production in Isfahan was for military purposes.”

Israel denied it had struck the nuclear enrichment facility in Fordo, about 100 kilometers (60 miles) southeast of Tehran.

Among those killed were three of Iran’s top military leaders: one who oversaw the entire armed forces, Gen. Mohammad Bagheri; one who led the paramilitary Revolutionary Guard, Gen. Hossein Salami; and the head of the Guard’s aerospace division, which oversees its arsenal of ballistic missile program, Gen. Amir Ali Hajizadeh. On Saturday, Khamenei named a new leader for the Revolutionary Guard’s aerospace division: Gen. Majid Mousavi.

The Fortune 500 Innovation Forum will convene Fortune 500 executives, U.S. policy officials, top founders, and thought leaders to help define what’s next for the American economy, Nov. 16-17 in Detroit. Apply here.
About the Authors
By Jon Gambrell
See full bioRight Arrow Button Icon
By Melanie Lidman
See full bioRight Arrow Button Icon
By Julia Frankel
See full bioRight Arrow Button Icon
By The Associated Press
See full bioRight Arrow Button Icon

Latest in Politics

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025

Most Popular

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Fortune Secondary Logo
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • Future 50
  • World’s Most Admired Companies
  • See All Rankings
Sections
  • Finance
  • Fortune Crypto
  • Features
  • Leadership
  • Health
  • Commentary
  • Success
  • Retail
  • Mpw
  • Tech
  • Lifestyle
  • CEO Initiative
  • Asia
  • Politics
  • Conferences
  • Europe
  • Newsletters
  • Personal Finance
  • Environment
  • Magazine
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
  • Group Subscriptions
About Us
  • About Us
  • Editorial Calendar
  • Press Center
  • Work At Fortune
  • Diversity And Inclusion
  • Terms And Conditions
  • Site Map
  • About Us
  • Editorial Calendar
  • Press Center
  • Work At Fortune
  • Diversity And Inclusion
  • Terms And Conditions
  • Site Map
  • Facebook icon
  • Twitter icon
  • LinkedIn icon
  • Instagram icon
  • Pinterest icon

Latest in Politics

trump
LawWhite House
Trump lawyers confirm talks with Scott Bessent’s IRS to resolve $10 billion lawsuit over leaked tax returns
By Fatima Hussein and The Associated PressApril 18, 2026
6 minutes ago
mississippi
RetailMississippi
Mississippi alcohol community roiled by liquor, wine delay from state warehouse failure
By Sophie Bates, Adrian Sainz and The Associated PressApril 18, 2026
18 minutes ago
Trump
PoliticsNew York
Trump backs down after New York sues him over Second Avenue Subway funding freeze
By Philip Marcelo and The Associated PressApril 18, 2026
23 minutes ago
iran
PoliticsIran
Trump on idea of Iran tolling the Strait of Hormuz: ‘Nope. No way. No. Nope.’
By The Associated PressApril 18, 2026
30 minutes ago
strait
EnergyIran
Iran closes Strait again, says it will be shut until Trump lifts blockade
By Samy Magdy, Sam Metz and The Associated PressApril 18, 2026
31 minutes ago
trump
CommentaryWhite House
Trump has already endorsed the Monroe Doctrine. Now he needs to endorse the Truman Doctrine
By Robert HormatsApril 18, 2026
49 minutes ago

Most Popular

Pope Leo warned the world is in ‘big trouble’ if Elon Musk becomes the first trillionaire
Success
Pope Leo warned the world is in ‘big trouble’ if Elon Musk becomes the first trillionaire
By Preston ForeApril 17, 2026
1 day ago
A world going broke: IMF says America's $39 trillion national debt is actually a global problem—and AI may be the only rescue
Economy
A world going broke: IMF says America's $39 trillion national debt is actually a global problem—and AI may be the only rescue
By Nick LichtenbergApril 16, 2026
2 days ago
Jeff Bezos pledged $10 billion for climate change. With the 2030 clock ticking, his wife, Lauren Sánchez Bezos, is leading the charge to spend it
Environment
Jeff Bezos pledged $10 billion for climate change. With the 2030 clock ticking, his wife, Lauren Sánchez Bezos, is leading the charge to spend it
By Sydney LakeApril 15, 2026
3 days ago
Older millennials are starting to act like boomers in the housing market—and pulling away from the pack
Real Estate
Older millennials are starting to act like boomers in the housing market—and pulling away from the pack
By Nick LichtenbergApril 17, 2026
1 day ago
Iran has reopened the Strait of Hormuz—but experts say it now holds a card that works ‘almost like a nuclear deterrent’
Energy
Iran has reopened the Strait of Hormuz—but experts say it now holds a card that works ‘almost like a nuclear deterrent’
By Eva RoytburgApril 17, 2026
18 hours ago
Germany already told its workers to ditch four-day weeks and work-life balance. Now the government wants to cut their pay for calling in sick, too
Success
Germany already told its workers to ditch four-day weeks and work-life balance. Now the government wants to cut their pay for calling in sick, too
By Orianna Rosa RoyleApril 16, 2026
2 days ago

© 2026 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.