• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia
TechStartups & Venture

This startup believes shopping around for prescription drugs should be as easy as shopping on Amazon. The future of a $700 billion industry is at stake

By
Jason Del Rey
Jason Del Rey
Former Tech Correspondent
Down Arrow Button Icon
By
Jason Del Rey
Jason Del Rey
Former Tech Correspondent
Down Arrow Button Icon
August 15, 2024, 9:00 AM ET
The three founders of Photon Health sitting on a brown sofa and posing for a photo.
Photon Health co-founders from left to right: Otto Sipe, Michael Rado, and Sam KotloveCourtesy of Photon Health

There’s a reason why most startup ideas focused on modernizing the prescription drug industry have failed: a byzantine system dominated by a group of all-powerful middlemen make an upstart’s chances of success infinitesimal. 

Recommended Video

Otto Sipe knows this well from nearly a decade of working for both startups and Walmart in and around the pharmacy and medical care spaces. But he thinks he has the right recipe and momentum to prove that he and his Brooklyn-based company can be one of the exceptions.

Sipe is the co-founder and CEO of Photon Health, a Brooklyn-based startup founded in 2021 that’s long term mission is to make shopping around for the best prices on prescription drugs as straightforward and convenient as online shopping for other products is today. In his telling, that long-term mission would one day manifest itself with the creation of an online marketplace where customers can go to browse the prices and in-stock availability of their prescription medications across pharmacies and choose from options including pharmacy pickup or on-demand home delivery. The hope is by increasing transparency, it might lead to competitive pressure to lower prices.

In short, the mission is to give some power back to the patients who are at the mercy of the $700 billion prescription drug market in the U.S. today. But to do that, Photon will likely need to secure buy-in from the giants of the pharmacy business. And that will take leverage. A lot of leverage.

“The cold-start phenomenon of a marketplace is very, very hard,” Sipe said. 

So the startup has entered the space in perhaps a counterintuitive way: by giving patients digital control of their prescriptions so they can easily pivot if their regular pharmacy doesn’t have their medication in-stock, is charging too much, or runs into some other issue filling the script.

This is how the model works. Photon sells so-called e-prescribing software to doctor’s offices and other health providers that allow them to send out a digital prescription for medication. Typically, a doctor would send an electronic prescription directly to a pharmacy but that can turn into a headache if the medication is out of stock or there’s another issue filling it, with a patient needing to get back in touch with a doctor’s office to reroute the electronic prescription to another pharmacy. These stresses compound if a physical doctor’s office is closed. 

Instead, doctors who use Photon send their patients an electronic prescription via a text message. The Photon website then lets the patient, or customer, choose from a variety of pharmacies that might include a national chain like Walgreens, a local independent pharmacy, or a modern mail-order provider like Amazon Pharmacy. When the medication is ready for pickup or has been delivered, Photon sends the customer an alert. Photon doesn’t currently route prescriptions for medications that qualify as controlled substances, but Sipe said his company will start doing so in 2025.

Thus far, Photon has focused on building its prescriber base by selling to virtual health providers like Sesame, Summer Health, and WeightWatchers’ clinic arm. In total, Photon is handling more than 70,000 electronic prescriptions in its network each month. That early momentum is important to investors like Nick Chirls, a partner at Notation Capital, a “pre-seed” investor that has now invested more than $3 million into the startup – the most funding his decade-old firm has ever invested in a single company. 

“If you can give patients control and visibility over their scripts, they can eventually go shopping like in any other area of ecommerce,” Chirls said in an interview with Fortune. “What does it mean when they can go shopping? They can choose drugs at the cheapest price from the most convenient place that actually has their drugs.”

Notation and the healthcare-focused firm Flare Capital Partners recently led a $9 million round in Photon Health. The startup has now raised north of $16 million in total from these firms and other VCs like Box Group, as well as angel investors including the founders of healthcare-related upstarts like Carbon Health and PillPack, which Amazon purchased for around $1 billion in 2018.

The main incumbent Photon is going after is Surescripts, a literal monopoly that makes software that doctors and other providers use to both deliver electronic prescriptions to pharmacies, and to check a patient’s eligibility for their insurance to cover a specific drug. The Federal Trade Commission sued the company in 2019, alleging that it was illegally maintaining a monopoly – a 95 percent “supershare” to be exact –– through anticompetitive behaviors, including exclusivity agreements. The two sides reached a settlement last year. 

“This is a crazy bet for people who work in health care,” Sipe said of Photon. “Surescripts is the untouchable monopoly…and there’s a battlefield littered with startups that have tried to take these guys out.”

“We don’t think we’re smarter than anyone else,” he added. “But we do think we have a different approach at a different point in time…and consumer demand for a better experience is so strong that that’s enough leverage to finally get over the hill.”

Join us at the Fortune Workplace Innovation Summit May 19–20, 2026, in Atlanta. The next era of workplace innovation is here—and the old playbook is being rewritten. At this exclusive, high-energy event, the world’s most innovative leaders will convene to explore how AI, humanity, and strategy converge to redefine, again, the future of work. Register now.
About the Author
By Jason Del ReyFormer Tech Correspondent
LinkedIn iconTwitter icon
See full bioRight Arrow Button Icon

Latest in Tech

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025

Most Popular

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Fortune Secondary Logo
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • World's Most Admired Companies
  • See All Rankings
  • Lists Calendar
Sections
  • Finance
  • Fortune Crypto
  • Features
  • Leadership
  • Health
  • Commentary
  • Success
  • Retail
  • Mpw
  • Tech
  • Lifestyle
  • CEO Initiative
  • Asia
  • Politics
  • Conferences
  • Europe
  • Newsletters
  • Personal Finance
  • Environment
  • Magazine
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
  • Group Subscriptions
About Us
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • Facebook icon
  • Twitter icon
  • LinkedIn icon
  • Instagram icon
  • Pinterest icon

Latest in Tech

How JPMorgan’s CIO is reshaping work at the bank with a $19.8 billion annual tech and AI budget
NewslettersCIO Intelligence
How JPMorgan’s CIO is reshaping work at the bank with a $19.8 billion annual tech and AI budget
By John KellApril 29, 2026
3 hours ago
hollywood
CommentaryMarketing
I spent 20 years learning to navigate an industry. Then I built a campaign for the man who’s dismantling it
By Matti YahavApril 29, 2026
7 hours ago
Current price of Ethereum for April 29, 2026
Personal FinanceEthereum
Current price of Ethereum for April 29, 2026
By Joseph HostetlerApril 29, 2026
7 hours ago
An excavator works to clear rubble after the East Wing of the White House was demolished on October 23, 2025 in Washington, DC. The demolition is part of U.S. President Donald Trump's plan to build a multimillion-dollar ballroom on the eastern side of the White House.
PoliticsWhite House
Meet all 37 White House ballroom donors funding the $400 million build, including Silicon Valley tech giants, crypto bros and the Lutnicks
By Nino Paoli and Fortune EditorsApril 29, 2026
8 hours ago
gen z
Commentarydisruption
AI won’t kill your job — it will kill the path to your first one
By Jeffrey Sonnenfeld, Stephen Henriques, Johan Griesel, Andrew Alam-Nist and Peter YuApril 29, 2026
9 hours ago
Christina Cacioppo poses while sitting down in a suit jacket
NewslettersTerm Sheet
Exclusive: Vanta hits $300 million ARR as ‘shadow AI’ explodes across corporate America
By Lily Mae LazarusApril 29, 2026
11 hours ago

Most Popular

Apple cofounder Ronald Wayne—whose stake would be worth up to $400 billion had he not sold it in 1976—says that at 91, he has no regrets
Success
Apple cofounder Ronald Wayne—whose stake would be worth up to $400 billion had he not sold it in 1976—says that at 91, he has no regrets
By Preston ForeApril 27, 2026
2 days ago
‘The cost of compute is far beyond the costs of the employees’: Nvidia executive says right now AI is more expensive than paying human workers
AI
‘The cost of compute is far beyond the costs of the employees’: Nvidia executive says right now AI is more expensive than paying human workers
By Sasha RogelbergApril 28, 2026
2 days ago
‘Take the money and run’: Johns Hopkins economist Steve Hanke on why the UAE quit OPEC
Energy
‘Take the money and run’: Johns Hopkins economist Steve Hanke on why the UAE quit OPEC
By Shawn TullyApril 29, 2026
14 hours ago
Current price of gold as of April 28, 2026
Personal Finance
Current price of gold as of April 28, 2026
By Danny BakstApril 28, 2026
1 day ago
The U.S. military may have already used up half of its most expensive missiles, and it could take up to 4 years to rebuild its stockpiles
Politics
The U.S. military may have already used up half of its most expensive missiles, and it could take up to 4 years to rebuild its stockpiles
By Sasha RogelbergApril 24, 2026
5 days ago
Current price of silver as of Tuesday, April 28, 2026
Personal Finance
Current price of silver as of Tuesday, April 28, 2026
By Joseph HostetlerApril 28, 2026
1 day ago

© 2026 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.