Fortune chooses which execs make this list based on five factors: the size of her business, the health of that business, the exec’s career trajectory, her cultural and societal influence, and how she uses her power.

At the top of the list for the third year in a row is CVS Health CEO Karen Lynch, whose health care company only got larger and more influential in the past year with two acquisitions totaling $19 billion. Others at the top include Accenture chief Julie Sweet (No. 2), GM CEO Mary Barra (No. 3), and Citigroup CEO Jane Fraser (No. 4).

In total, this year’s list features 67 CEOs and 53 newcomers. Sixty-one women are from the Americas, while 23 are based in EMEA, and 16 are in the Asia-Pacific region. Finance and tech top the list with 20 execs each, followed by retail with 18.

Some notable names from the tech industry include Meta CFO Susan Li (No. 18), OpenAI CTO Mira Murati (No. 57), and X CEO Linda Yaccarino (No. 58).

The startup world is also represented, with Canva cofounder Melanie Perkins (No. 93) and Skims and SKKY Partners cofounder Kim Kardashian (No. 88), who both wield influence beyond the size and stage of their businesses. We have a few newcomers from the fashion industry, too—Chanel CEO Leena Nair (No. 70), a Unilever alum, and LVMH heiress and Dior CEO Delphine Arnault (No. 45). Sue Nabi, the CEO of beauty giant Coty Inc. and an openly trans woman, is on the list at No. 87.

The turbulence of the past few years has opened the doors for female executives. Amid high CEO turnover in the first half of this year, 13% of CEO successors globally were women compared to only 2.4% in 2018, according to Russell Reynolds.

The 100 women on this list are at the front of those trends—or poised to be there soon.

See the full list here.

Emma Hinchliffe
emma.hinchliffe@fortune.com
@_emmahinchliffe

The Broadsheet is Fortune’s newsletter for and about the world’s most powerful women. Today’s edition was curated by Joseph Abrams. Subscribe here.

ALSO IN THE HEADLINES

- AI upside. At Fortune’s CEO Initiative conference on Tuesday, Treasury Secretary Janet Yellen shared her optimistic outlook that AI could be a pick-me-up for the economy. Yellen said AI assistance and task automation could bring a beneficial boost in productivity. Fortune

- Step by step. Another Fortune CEO Initiative attendee, U.S. Commerce Secretary Gina Raimondo, told Fortune editor-in-chief Alyson Shontell that she's banking on a “baby step” solution to rebuild ties between China and the U.S. Raimondo said that a working group between the countries already began meeting together in hopes that small moves like this eventually "lead to bigger steps." Fortune

- Master of fund. Hong Kong financial veteran Clara Chan Ka-chai will oversee HK$62 billion (US$8 billion) in funds as the new CEO of Hong Kong Investment Corporation, a wealth fund looking to attract new businesses and investments to Hong Kong and surrounding areas. Chan will take over the role next Monday after a stint as executive director of monetary management at the Hong Kong Monetary Authority, during which the she led the multi-billion dollar bailout of airline Cathay Pacific. South China Morning Post

- Tech protection. Emma Pickering leads the tech abuse team at British domestic abuse organization Refuge. With abusers now infiltrating home Ring cameras and using miniature tracking devices, Pickering is working with victims to clean up their digital tools; she even cocreated a breakup app that helps separate formerly shared accounts. Wired

- Passing to EEOC. Former Las Vegas Aces player Dearica Hamby filed a gender discrimination complaint with the Equal Employment Opportunity Commission against the WNBA team and the league itself last week, alleging that the team created a hostile work environment and eventually traded her after she revealed she was pregnant. The complaint accuses the WNBA of not properly investigating the Aces after Hamby publicly criticized the team in January. The WNBA and the Aces have not yet responded to the complaint. Washington Post

MOVERS AND SHAKERS: Lift Our Voices appointed Barbara Polk as president. Maven named Kristina Campbell as chief financial officer.

ON MY RADAR

She influenced decades of design with blingy, colorful textiles. A new exhibit pays tribute AP

Monica Lewinsky is a bully Cosmopolitan

The most influential woman in fashion New York Times

PARTING WORDS

"The second I got a taste of what it felt like to be confident, not only did I not want to let that feeling go, I wanted to bring other people into the light."

—Makeup artist, Peloton instructor, and Nike athlete Tunde Oyeneyin on using her cycling classes to motivate herself, and her students, to be more confident