• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia
Health

Fentanyl and related drugs are killing more people than guns and cars combined. Many victims don’t realize they’re even taking it

By
Geoff Mulvihill
Geoff Mulvihill
and
The Associated Press
The Associated Press
Down Arrow Button Icon
By
Geoff Mulvihill
Geoff Mulvihill
and
The Associated Press
The Associated Press
Down Arrow Button Icon
October 28, 2022, 2:19 PM ET
A fentanyl user holds a needle in Philadelphia this month.
A fentanyl user holds a needle in Philadelphia this month. David Maialetti—The Philadelphia Inquirer via AP

Lillianna Alfaro was a recent high school graduate raising a toddler and considering joining the Army when she and a friend bought what they thought was the anti-anxiety drug Xanax in December 2020.

The pills were fake and contained fentanyl, an opioid that can be 50 times as powerful as the same amount of heroin. It killed them both.

“Two years ago, I knew nothing about this,” said Holly Groelle, the mother of 19-year-old Alfaro, who lived in Appleton, Wisconsin. “I felt bad because it was something I could not have warned her about, because I didn’t know.”

The drug that killed her daughter was rare a decade ago, but fentanyl and other lab-produced synthetic opioids now are driving an overdose crisis deadlier than any the U.S. has ever seen. Last year, overdoses from all drugs claimed more than 100,000 lives for the first time, and the deaths this year have remained at nearly the same level — more than gun and auto deaths combined.

The federal government counted more accidental overdose deaths in 2021 alone than it did in the 20-year period from 1979 through 1998. Overdoses in recent years have been many times more frequent than they were during the black tar heroin epidemic that led President Richard Nixon to launch his War on Drugs, or during the cocaine crisis in the 1980s.

As fentanyl gains attention, mistaken beliefs persist about the drug, how it is trafficked and why so many people are dying.

Experts believe deaths surged not only because the drugs are so powerful, but also because fentanyl is laced into so many other illicit drugs, and not because of changes in how many people are using. In the late 2010s — the most recent period for which federal data is available — deaths were skyrocketing even as the number of people using opioids was dropping.

Advocates warn that some of the alarms being sounded by politicians and officials are wrong and potentially dangerous. Among those ideas: that tightening control of the U.S.-Mexico border would stop the flow of the drugs, though experts say the key to reining in the crisis is reducing drug demand; that fentanyl might turn up in kids’ trick-or-treat baskets this Halloween; and that merely touching the drug briefly can be fatal — something that researchers found untrue and that advocates worry can make first responders hesitate about giving lifesaving treatment.

All three ideas were brought up this month in an online video billed as a pre-Halloween public service announcement from a dozen Republican U.S. senators.

A report this year from a bipartisan federal commission found that fentanyl and similar drugs are being made mostly in labs in Mexico from chemicals shipped primarily from China.

In New England, fentanyl has largely replaced the supply of heroin. Across the country, it’s being laced into drugs such as cocaine and methamphetamine, sometimes with deadly results. And in cases like Alfaro’s, it’s being mixed in Mexico or the U.S. with other substances and pressed into pills meant to look like other drugs.

The U.S. Drug Enforcement Agency has warned that fentanyl is being sold in multicolored pills and powders — sometimes referred to as “rainbow fentanyl” — marketed on social media to teens and young adults.

Jon DeLena, the agency’s associate special agent in charge, said at the National Crime Prevention Council summit on fentanyl in Washington this month that there’s “no direct information that Halloween is specifically being targeted or young people are being targeted for Halloween,” but that hasn’t kept that idea from spreading.

Joel Best, an emeritus sociology professor at the University of Delaware, said that idea falls in with a long line of Halloween-related scares. He has examined cases since 1958 and has not found a single instance of a child dying because of something foreign put into Halloween candy — and few instances of that being done at all.

“If you give a dose of fentanyl to kids in elementary school, you have an excellent chance of killing them,” he said. “If you do addict them, what are you going to do, try to take their lunch money? No one is trying to addict little kids to fentanyl.”

In midterm election campaigns, fentanyl is not getting as much attention as issues such as inflation and abortion. But Republicans running for offices including governor and U.S. Senate in Arkansas, New Mexico and Pennsylvania have framed the fentanyl crisis as a result of Democrats being lax about securing the Mexican border or soft on crime as part of a broader campaign assertion that Democrats foster lawlessness.

And when Democrats highlight the overdose crisis in campaigns this year, it has often been to tout their roles in forging settlements to hold drugmakers and distributors responsible.

Relying heavily on catching fentanyl at the border would be futile, experts say, because it’s easy to move in small, hard-to-detect quantities.

“I don’t think that reducing the supply is going to be the answer because it’s so easy to mail,” said Adam Wandt, an assistant professor at John Jay College of Criminal Justice.

Still, some more efforts are planned on the U.S.-Mexico border, including increasing funding to search more vehicles crossing ports of entry. The bipartisan commission found those crossings are where most fentanyl arrives in the country.

The commission is calling for many of the measures that other advocates want to see, including better coordination of the federal response, targeted enforcement, and measures to prevent overdoses for those who use drugs.

The federal government has been funding efforts along those lines. It also publicizes bigfentanylseizures by law enforcement, though it’s believed that even the largest busts make small dents in the national drug supply.

The commission stopped short of calling for increased penalties for selling fentanyl. Bryce Pardo, associate director of the RAND Drug Policy Research Center and a commission staff member, said such a measure would not likely deter the drug trade. But, he said, dealers who sell the products most likely to cause death — such as mixing fentanyl into cocaine or pressing it into fake Xanax — could be targeted effectively.

One California father who lost his 20-year-old daughter is pushing for prosecutors to file murder charges against those who supply fatal doses.

Matt Capelouto’s daughter Alexandra died from half a pill she bought from a dealer she found on social media in 2019, while home in Temecula, California, during a college break. She was told the pill was oxycodone, Capelouto said, but it contained fentanyl.

The dealer was charged with distributing fentanyl resulting in death, but he reached a plea deal on a lesser drug charge and will face up to 20 years in prison.

“It’s not that arresting and convicting and putting these guys behind bars doesn’t work,” Capelouto said. “The fact is we don’t do it enough to make a difference.”

While some people killed by fentanyl have no idea they’re taking it, others, particularly those with opioid use disorder, know it is or could be in the mix. But they may not know how much is in their drugs.

That was the case for Susan Ousterman’s son Tyler Cordiero, who died at 24 in 2020 from a mixture that included fentanyl after years of using heroin and other opioids.

For nearly two years, Ousterman avoided going by the gas station near their home in Bensalem, Pennsylvania, where her son fatally overdosed. But in August, she went to leave two things there: naloxone, a drug used to reverse overdoses, and a poster advertising a hotline for people using drugs to call so the operator could call for help if they become unresponsive.

Ousterman is funneling her anger and sorrow into preventing other overdoses.

“Fentanyl is everywhere,” she said. “You don’t know what’s in an unregulated drug supply. You don’t know what you’re taking. You’re always taking the chance of dying every time.”

—AP journalists Lindsay Whitehurst in Washington and Kavish Harjai in Los Angeles contributed. 

Sign up for the Fortune Features email list so you don’t miss our biggest features, exclusive interviews, and investigations.
About the Authors
By Geoff Mulvihill
See full bioRight Arrow Button Icon
By The Associated Press
See full bioRight Arrow Button Icon

Latest in Health

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025

Most Popular

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Fortune Secondary Logo
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • World's Most Admired Companies
  • See All Rankings
  • Lists Calendar
Sections
  • Finance
  • Fortune Crypto
  • Features
  • Leadership
  • Health
  • Commentary
  • Success
  • Retail
  • Mpw
  • Tech
  • Lifestyle
  • CEO Initiative
  • Asia
  • Politics
  • Conferences
  • Europe
  • Newsletters
  • Personal Finance
  • Environment
  • Magazine
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
  • Group Subscriptions
About Us
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • Facebook icon
  • Twitter icon
  • LinkedIn icon
  • Instagram icon
  • Pinterest icon

Latest in Health

The 10 Best Mother’s Day Gifts in 2026: Must Haves for Your Mom
HealthDietary Supplements
The 10 Best Mother’s Day Gifts in 2026: Must Haves for Your Mom
By Christina SnyderMay 5, 2026
6 hours ago
How the next CDC director could reshape America’s $5.3 trillion health care industry
HealthCDC
How the next CDC director could reshape America’s $5.3 trillion health care industry
By Cassie McGrath and Healthcare BrewMay 5, 2026
8 hours ago
A man shaves wood pieces from a block.
EconomyRetirement
Economists have found an answer to slowing cognitive decline: avoid retiring early, study finds
By Sasha RogelbergMay 5, 2026
10 hours ago
Japanese workers commuting to the office
Successcorporate culture
Tokyo is throwing out its strict office dress code and asking workers to wear shorts amid the war in Iran energy crisis
By Emma BurleighMay 5, 2026
10 hours ago
A Spirit Airlines airplane
HealthAirline industry
The viral TikTok $1.75 billion bid to save Spirit Airlines is fighting the wrong villain
By Eva RoytburgMay 5, 2026
11 hours ago
Tired woman trying to sleep, life difficulties, feeling lonely and frustrated
Healthsleep
The dark side of the American work ethic: widespread sleep deprivation, linked to obesity, depression, even early death
By Tristan BoveMay 4, 2026
1 day ago

Most Popular

Clean energy's winning argument is the one it refuses to make
Commentary
Clean energy's winning argument is the one it refuses to make
By David CraneMay 5, 2026
15 hours ago
Diary of a CEO founder says he hired someone with 'zero' work experience because she 'thanked the security guard by name' before the interview
Success
Diary of a CEO founder says he hired someone with 'zero' work experience because she 'thanked the security guard by name' before the interview
By Emma BurleighMay 3, 2026
3 days ago
Current price of oil as of May 5, 2026
Personal Finance
Current price of oil as of May 5, 2026
By Joseph HostetlerMay 5, 2026
14 hours ago
Current price of silver as of Monday, May 4, 2026
Personal Finance
Current price of silver as of Monday, May 4, 2026
By Joseph HostetlerMay 4, 2026
2 days ago
Gen Z workers say showing up 10 minutes late to work is as good as on time—but baby boomer bosses have zero tolerance for tardiness, research reveals
Success
Gen Z workers say showing up 10 minutes late to work is as good as on time—but baby boomer bosses have zero tolerance for tardiness, research reveals
By Orianna Rosa RoyleMay 5, 2026
13 hours ago
China stopped issuing new robotaxi licenses over a glitch. America can't stop them from rolling into active shooter situations
Law
China stopped issuing new robotaxi licenses over a glitch. America can't stop them from rolling into active shooter situations
By Catherina GioinoMay 4, 2026
1 day ago

© 2026 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.