Endo Health Solutions (Nasdaq: ENDP) has acquired Paladin Labs (TSX: PLB), a Canadian specialty pharma company, for approximately $1.6 billion in stock and cash. The deal represents a 20% premium to Paladin’s closing price on Monday. www.endo.com

Office Depot (NYSE: ODP) has completed its $979 million acquisition of OfficeMax Inc.www.officedepot.com

Open Text Corp. (Nasdaq: OTX) has agreed to acquire GXS Group Inc., a Gaithersburg, Md.-based cloud services company, for $1.17 billion. www.opentext.com

Apogee Enterprises Inc. (Nasdaq: APOG) has acquired Alumicor Ltd., a maker of aluminum frames for the Canadian commercial construction market, from Fulcrum Capital Partners and six minority shareholders. The deal was valued at $52 million. www.apog.com

Centro, a Chicago-based digital media software and services company backed by FTV Capital, has acquired SiteScout, a Seattle-based self-serve, real-time bidding platform. The deal is valued just south of $40 million in cash and stock. The seller is Rubicon Project, which has raised VC funding from Clearstone Venture Partners, Mayfield Fund, Peacock Equity and IDG Ventures Asia. www.centro.net

Arc Logistics Partners LP, an energy logistics group sponsored by Lightfoot Capital, raised $114 million in its IPO. The company priced 6 million shares at $19 per share (low end of $19-$21 range), and will trade on the NYSE under ticker symbol ARCX. Citigroup and Barclays served as lead underwriters.

Avianca Holdings, a Latin American airline based in Panama, raised $409 million in its IPO. The company priced 27.23 million shares at $15 per share (below $17-$20 range). It will trade on the NYSE under ticker symbol AVH, and to continue trading on the Colombian Stock Exchange under symbol PFAVH. J.P. Morgan and Citigroup are serving as lead underwriters. www.aviancataca.com

Barracuda Networks Inc., a Campbell, Calif.-based provider of content security, data protection, and application delivery solutions, raised $75 million in its IPO. The company priced 4.14 million shares at $18 per share (low end of $18-$20 range), for an initial market cap of approximately $900 million. It will trade on the NYSE under ticker symbol CUDA, with Morgan Stanley, J.P. Morgan and BoA Merrill Lynch serving as lead underwriters. It reports a $4.9 million net loss on $114 million in revenue for the six months ending August 31. Barracuda recently raised $130 million via recap funding from Francisco Partners (26.5% pre-IPO stake) and Sequoia Capital (17.4%). www.barracudanetworks.com

Karyopharm Therapeutics, a Natick, MA-based developer of drugs directed against nuclear transport targets for the treatment of cancer and other major diseases, raised $109 million in its IPO. The company priced 6.8 million shares at $16 per share, compared to original plans to offer 5.67 million shares at between $14 and $16 per share. It will trade on the Nasdaq under ticker symbol KPTI, with BoA Merrill Lynch and Leerink Swann serving as lead underwriters. The company has raised over $70 million in VC funding from firms like Foresite Capital (9.42% pre-IPO stake), Delphi Ventures (8.17%) and New Leaf Venture Partners. www.karyopharm.com

Wix, an Israeli company that helps users build HTML5 websites, raised $127 million in its IPO. The company priced 7.7 million shares at $16.50 per share (high end of $14.50-$16.50 range, for an initial market cap of around $601 million). It will trade on the Nasdaq under ticker symbol WIX, while J.P. Morgan, BofA Merrill Lynch and RBC Capital Markets served as lead underwriters. It reports an $18 million net loss on $55.5 million in revenue for the first half of 2013. It has raised around $61 million in VC funding from  Mangrove Capital (22.5% pre-IPO stake), Bessemer Venture Partners (21.7%), Benchmark (11%), Insight Venture Partners (10.2%) and DAG Ventures. www.wix.com

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