Adobe Systems (Nasdaq: ADBE) has acquired mobile app design agency Thumb Labs for an undisclosed amount. www.adobe.com

BTG PLC (LSE: BTG) has agreed to acquire the Targeted Therapies division of Nordion Inc. (TSX: NDN) for approximately US$200 million. www.btgplc.com

Google (Nasdaq: GOOG) has acquired Makani Power, an Alameda, Calif.-based developer of wind energy extraction technologies. No financial terms were disclosed. Makani had raised over $10 million in VC funding from Google and Google.org. www.makanipower.com

BTG PLC (LSE: BTG) has agreed to acquire EKOS Corp., a Bothell, Wash.–based maker of ultrasound systems for treating vascular thrombosis, for approximately $180 million (plus up to $40m in milestone payments). EKOS has raised over $90 million in VC funding from ARCH Venture Partners, Bessemer Venture Partners, Merrill Lynch, Mitsui & Co., Spray Venture Partners, MedVenture Associates, Protostar, Technology Partners and Morgan Stanley Venture Partners.www.ekoscorp.com

Seaport Capital has sold MCV Broadband, a provider of triple-play broadband services in Guam, to Japan’s NTT Docomo Inc. for approximately $130 million. www.mcvguam.com

ChannelAdvisor Corp., a Morrisville, N.C.-based provider of SaaS-based merchandise sales management solutions for retailers and manufacturers, raised $81 million in its IPO. The company priced 5.8 million shares at $14 per share (high end of $12-$14 range), and will trade on the NYSE under ticker symbol ECOM. Goldman Sachs and Stifel served as lead underwriters. The company reports a $4.9 million net loss on $38.8 million in revenue for 2012, compared to a $3.8 million net loss on $31.3 million in revenue for 2012. It has raised around $75 million in VC funding, from firms like Kodiak Venture Partners (24.4% pre-IPO stake), New Enterprise Associates (24%) and Advanced Technology Ventures (18.5%). www.channeladvisor.com

Global Brass & Copper Holdings Inc., a Schaumberg, Ill.-based maker of copper and brass products, raised around $77 million in its IPO. The company priced 7 million shares at $11 per share (low end of downwardly-revised range), and will trade on the NYSE under ticker symbol BRSS. Goldman Sachs and Morgan Stanley served as co-lead underwriters. The company reports $12.9 million in net income on around $1.65 billion in revenue for 2012. All of the shares were offered by KPS Capital Partners, whose post-IPO ownership position fell below 70%. www.gbcmetals.com

Ply Gem Holdings Inc., a Cary, N.C.-based maker of exterior building products, raised $332 million in its IPO. The company priced 15.8 million shares at $21 per share (above $18-$20 range), and will trade on the NYSE under ticker symbol PEGM. J.P. Morgan, Credit Suisse and Goldman Sachs serving as co-lead underwriters. CI Capital is PlyGem’s majority shareholder. www.plygem.com

Portola Pharmaceuticals, a South San Francisco-based drug company focused on cardiovascular and autoimmune/inflammatory diseases, raised $122 million in its IPO. The company priced 8.4 million shares at $14.50 per share, compared to plans to offer 6.9 million shares at between $13 and $16 each. It will trade on the Nasdaq under ticker symbol PTLA, while Morgan Stanley and Credit Suisse served as co-lead underwriters. Portola had raised over $300 million in VC funding, from firms like Temasek (13.9% pre-IPO stake), MPM Capital (9.6%), Prospect Venture Partners (7.1%), Brookside Capital (7%), Sutter Hill Ventures (7%), Eastern Capital (7%), Advanced Technology Ventures (6.1%), Frazier Healthcare (5.7%), AllianceBernstein, Alta Partners, CIDC Consulting, D.E. Shaw, Goldman Sachs, IBT Management Corp., Teachers’ Private Capital, T. Rowe Price, Apothecary Capital, Janus Capital, Biogen Idec and PAC-Link BioVentures. www.portola.com

Noodles & Co., a Broomfield, Colo.-based fast casual restaurant concept , has filed for a $75 million IPO. It plans to trade on the NYSE under ticker symbol NDLS, with Morgan Stanley and UBS serving as lead underwriters. The company reports around $5 million in net income on $300 million in revenue for 2012, compared to $3.8 million on $256 million in 2011. Catterton Partners and Argentia Private Investments each hold around a 45% pre-IPO stake. www.noodles.com

General Electric Co. (NYSE: GE) is considering spinning off part of its GE Finance unit via an IPO, according to comments made yesterday during a conference by company CEO Jeff Immelt.

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