• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia
FinanceMartin Shkreli

How Martin Shkreli Allegedly Created a ‘Ponzi Scheme’ With Biotech Stocks

By
Jen Wieczner
Jen Wieczner
Down Arrow Button Icon
By
Jen Wieczner
Jen Wieczner
Down Arrow Button Icon
December 17, 2015, 4:12 PM ET
Martin Shkreli, CEO Reviled for Drug Price Gouging, Arrested on Securities Fraud Charges
Martin Shkreli, chief executive officer of Turing Pharmaceuticals LLC, center, exits federal court in New York, U.S., on Thursday, Dec. 17, 2015. Shkreli was arrested on alleged securities fraud related to Retrophin Inc., a biotech firm he founded in 2011. Photographer: Peter Foley/Bloomberg via Getty ImagesPhotograph by Bloomberg via Getty Images

There’s an old adage among short-sellers: “He that sells what isn’t his’n, must buy it back or go to prison.” Forgetting that simple rhyme may have been the undoing of Martin Shkreli, the biotech short-seller turned controversial CEO of Turing Pharmaceuticals who was arrested Thursday.

Shkreli was indicted for securities fraud and conspiracy in a series of dealings that federal prosecutors likened to a “Ponzi scheme.” After racking up losses while running hedge fund firm MSMB Capital Management, which made bets against biotech stocks, Shkreli formed a biotech company of his own called Retrophin (RTRX) in 2011. He effectively used the company as his own personal piggybank to pay back his and the MSMB funds’ debts, according to the charges brought by the FBI and a separate SEC complaint. (None of the charges mention anything about Shkreli’s infamous drug price hikes at his new company Turing.)

The original downfall of the funds came down to one stock, according to the indictment: Orexigen Therapeutics (OREX). To short biotech stocks, Shkreli would have had to borrow shares in biotech companies, sell them, and ideally buy them back and return them at a lower price in order to pocket the difference. What he supposedly did wrong: The indictment says that in 2011, Shkreli sold short 32 million shares of Orexigen—but he never actually borrowed all of them. The MSMB fund “failed to locate” the rest of the shares it owed, taking a loss of more than $7 million.

“Shkreli essentially ran his companies like a Ponzi scheme, where he used each subsequent company to pay off the defrauded investors in the prior company,” U.S. Attorney Robert Capers told the press in a statement after Shkreli’s arrest.

Out of money, Shkreli’s hedge fund stopped trading the same month of the failed Orexigen bet, the charges state. But almost a year later, in 2012, Shkreli was still telling his investors that they’d “doubled their money,” when in reality they’d lost everything. Around the same time, Shkreli founded Retrophin, and according to the indictment, he immediately began siphoning that company’s assets, diverting $11 million in cash and stock to himself and his hedge fund shareholders.

He did this by arranging meritless “settlement agreements” and “sham consulting agreements” with his fund investors, who did not actually do any “legitimate” consulting, the indictment states. And upon seeing a share transfer contract falsely backdated with “clearly visible redacting tape,” one accountant responded simply in an email: “WT….F.”

Federal prosecutors even suggest that Shkreli may have had an indirect role in bringing down the economy in 2008, contributing in a small way to the collapse of Lehman Brothers. In fact, MSMB wasn’t the first hedge fund he ran into the ground, having “lost all the money” in a previous fund that still owed Lehman $2.3 million in 2007, a court ruled at the time. Of course, Shkreli didn’t mention any of that to his investors in the later fund, the indictment notes.

Shkreli is free on a $5 million bond, which is more than twice what he recently paid for a deluxe copy of the Wu-Tang Clan album Once Upon a Time in Shaolin. His arrest comes just a day after a published interview with the website HipHopDX in which he sounded off on everything from his business practices to the Wu-Tang Clan to Taylor Swift in colorful language that most CEOs wouldn’t use on the record.

About the Author
By Jen Wieczner
See full bioRight Arrow Button Icon

Latest in Finance

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025

Most Popular

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • Future 50
  • World’s Most Admired Companies
  • See All Rankings
Sections
  • Finance
  • Leadership
  • Success
  • Tech
  • Asia
  • Europe
  • Environment
  • Fortune Crypto
  • Health
  • Retail
  • Lifestyle
  • Politics
  • Newsletters
  • Magazine
  • Features
  • Commentary
  • Mpw
  • CEO Initiative
  • Conferences
  • Personal Finance
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
About Us
  • About Us
  • Editorial Calendar
  • Press Center
  • Work At Fortune
  • Diversity And Inclusion
  • Terms And Conditions
  • Site Map
  • Facebook icon
  • Twitter icon
  • LinkedIn icon
  • Instagram icon
  • Pinterest icon

Most Popular

placeholder alt text
Economy
An unusual Fed ‘rate check’ triggered a free fall in the U.S. dollar and investors are fleeing into gold
By Jim EdwardsJanuary 26, 2026
17 hours ago
placeholder alt text
Success
Despite running $75 billion automaker General Motors, CEO Mary Barra still responds to ‘every single letter’ she gets by hand
By Preston ForeJanuary 26, 2026
13 hours ago
placeholder alt text
Politics
Trump was surging after the Venezuela raid—then came Jerome Powell, Greenland, and Minnesota. Now it feels like a ‘historic hinge moment’
By Jason MaJanuary 25, 2026
1 day ago
placeholder alt text
Personal Finance
Sweden abolished its wealth tax 20 years ago. Then it became a 'paradise for the super-rich'
By Miranda Sheild Johansson and The ConversationJanuary 22, 2026
5 days ago
placeholder alt text
North America
Gates Foundation plans to give away $9 billion in 2026 to prepare for the 2045 closure while slashing hundreds of jobs
By Sydney LakeJanuary 23, 2026
3 days ago
placeholder alt text
Success
'The Bermuda Triangle of Talent': 27-year-old Oxford grad turned down McKinsey and Morgan Stanley to find out why Gen Z’s smartest keep selling out
By Eva RoytburgJanuary 25, 2026
2 days ago

© 2026 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.


Latest in Finance

EconomyTariffs and trade
Trump threatens to hike tariffs on South Korea as national assembly has yet to approve last year’s trade deal
By Josh Boak, Hyung-Jin Kim and The Associated PressJanuary 26, 2026
5 hours ago
markets
InvestingMarkets
S&P 500 wins back all losses from Greenland dip, gold and silver surge even higher
By Stan Choe and The Associated PressJanuary 26, 2026
6 hours ago
Bridgewater Associates founder Ray Dalio sits in a chair and talks
PoliticsDonald Trump
Ray Dalio says the U.S. is a ‘tinderbox’ after the Minneapolis shooting and Trump risks a ‘more clear civil war’
By Jake AngeloJanuary 26, 2026
7 hours ago
Photo of Donald Trump
EconomyFinance
Trump’s own Big Beautiful Bill could add $5.5 trillion to the deficit and help sabotage his plan to ‘grow out’ of the national debt crisis
By Shawn TullyJanuary 26, 2026
8 hours ago
economy
EnvironmentWeather and forecasting
The billion-dollar storm? Economists debate how much activity Winter Storm Fern laid waste to
By Seth Borenstein and The Associated PressJanuary 26, 2026
9 hours ago
IRS
LawWhite House
Trump’s latest retribution hits Booz Allen, whose contractor was charged with leaking tax returns to the press
By Fatima Hussein and The Associated PressJanuary 26, 2026
9 hours ago