Brainstorm Health: Tiny Killers, OxyContin Marketing, Flu Season Update

Laurie Garrett, one of the globe’s most gifted writers on global public health issues, has a timely and scary essay on foreignpolicy.com about the nasty norovirus plaguing athletes in the Olympic village—a bug one expert calls the “perfect human pathogen.” Though the virus rarely kills people, it is “so contagious and causes such violent illness to further spread its progeny that is virtually impossible to eliminate…from a crowded human environment,” writes Garrett. Remarkably sticky on surfaces, brilliant at hitchhiking rides on everything from shoes to door handles, and infectious at even sparse concentrations of viral particles, noroviruses are truly Gold-medal favorites in the Germ Olympics.

The recent Lassa fever death in Guinea—the first in more than two decades, as the Washington Post notes—is worrisome for a number of reasons, but one of those is where the Guinean victim died: next door in Liberia. The cross-border fatality conjures up bad memories of another hemorrhagic fever, Ebola, which freely crossed borders in the horrific 2014 West African outbreak. (Also raising concern is how long it apparently took health officials to publicly report the death. The infected person died nearly a month ago, on Jan. 11.)

And the flu? Its power to sicken and kill is made clear year after year after year—and still we seem surprised by its morbid rage…year after year after year.

These little invisible beasts—whether they be RNA-based noroviruses, arenaviruses like Lassa, or influenza viruses—evolve as we do…only much, much faster. And many of them are world travelers to boot, collecting frequent flier miles as if they were globetrotting CEOs.

For those curious and intrepid, the NIH has a handy manifest of Emerging Infectious Diseases, or EIDs, which it breaks down into three categories, based on the priority of the threat.

The scariest of these EIDs, from a population health standpoint, aren’t the ones that kill the most, but rather the ones that get lots of people pretty darn sick. The pathogens on this list also disseminate with moderate ease and, say health officials, “require specific enhancements for diagnostic capacity” in order to identify them rapidly—a level of readiness we simply don’t have for many new infectious diseases.

Why do I bring this up on a beautiful Monday morning? To remind us that we—and I speak here of both the American “we” and the global “we”—don’t yet have a good defensive plan to deal with these threats. The nightly news reports about the brutal seasonal flu, now widespread across our great land, haven’t jumpstarted efforts to build (and fund) such a plan.

And if that hasn’t done it—and if Zika and Ebola and SARS didn’t do it before that—I don’t want to imagine what will.

DIGITAL HEALTH

A video game helps calm schizophrenia patients. A small pilot study of schizophrenia patients found that a particular video game where the user has to land a rocket helped the patients control verbal hallucinations. The study participants were asked to develop strategies for landing the rocket mentally; this, in turn, allowed the patients to strategize ways of blocking out hallucinatory voices inside their heads. (BBC)

INDICATIONS

David Hung exits Axovant after Alzheimer's debacle. Axovant shares tumbled another 20% Monday after CEO David Hung, the former chief of Medivation who orchestrated the latter company's sale to Pfizer, resigned from the post after less than a year on the job. Axovant had a devastating setback in its Alzheimer's drug program last year, leading industry observers to question whether parent company Roivant's unusual approach to drug development will yield substantial successes any time soon. (Nasdaq)

OxyContin manufacturer's marketing rollback. OxyContin maker Purdue Pharma will no longer market its powerful, flagship opioid to doctors, a marked reversal precipitated by the opioid painkiller addiction and overdose crisis. The company will also cut its U.S. sales staff in half—but, given Purdue's prominent role in boosting OxyContin as a pain treatment, some public health experts are questioning whether the move comes too late. (Fortune)

THE BIG PICTURE

The flu's killing 4,000 Americans per week. Just how bad is this year's flu season? It's killing up to 4,000 Americans every week, according to the Centers for Disease Control (CDC). The flu season is now likely on pace to claim even more lives than the 2009-2010 swine flu epidemic, and officials say it will linger for weeks to come. (Fortune)

REQUIRED READING

New York Attorney General Sues Weinstein Company, by Natasha Bach

Airbus Shows Off Its New Automated Drone Delivery Service, by David Meyer

What's Stunning About the Uber-Waymo Settlement, by Aaron Pressman and Adam Lashinsky

Unilever Threatens to Pull Ads from Social Media, by Hallie Detrick