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Sleep researchers have identified a gene which affects sleep.

By Laura Entis
May 6, 2017

Michael W. Young has been studying sleep disorders for more than 45 years. When he started his research, as a graduate student at the University of Texas in the early 1970s, the field was largely unformed.

We still don’t know exactly why we sleep, but in the intervening decades we’ve learned a lot about the underlying mechanisms. For one, we now know about circadian rhythm, or the body’s internal clock, which dictates sleep-wake cycles. More specifically, we’re starting to pinpoint why this cycle often gets disrupted. By isolating the mutations responsible for changes in the circadian rhythm in flies and mice, researchers are beginning to identify corresponding genes in humans. It’s a slow and imperfect process—we’re (reassuringly) far more complex than either species—but we’re gaining a better understanding of how our genes influence our sleep. For example, Young and a team of researchers recently published a paper in Cell that links delayed sleep phase disorder to a mutation in the CRY1 gene.

Whereas in the past, being a “night owl” or a “morning lark” was attributed to vague mix of genetics and personal preferences, the study gets specific. Those with either one or two copies of the variant CRY1 gene, it found, displayed a more than two-hour shift in night sleep times. Their circadian cycle was delayed, meaning they had a difficult time falling asleep before 2 a.m. or 3 a.m., and, if able, would sleep until 10 a.m. or later.

While it’s unclear the percentage of people with the mutation—it’s likely far less than the percentage of people who identify as night owls, which suggests environmental factors are also at play—the study is a good reminder that sleep is complicated. Our understanding is evolving; there’s still a lot we don’t know.

What is clear: a lack of sleep predisposes us to a host of health issues, including diabetes, obesity and depression. That’s a problem, because many of us aren’t getting enough of it. Between 50 million and 70 million adults in the U.S. have a sleep disorder, according to The Centers for Disease Control and Prevention.

Below, Young outlines some factors believed to play a large role in determining when, and how well, we sleep, along with strategies for adopting a more normal sleep-wake cycle—even when our genetics seem to be hardwired against it.

One clock to rule them all

We evolved on a planet governed by cyclical fluctuations in light and temperature. Over the course of millions of years, our circadian rhythms “developed to anticipate these changes,” says Young. Our internal clocks work on a cellular level; appetite, metabolism, and sleep, along with other bodily functions, are designed to align with daily and yearly shifts in brightness and heat.

A standard circadian rhythm, then, essentially tracks the sun. Enzymes are released in the morning to stimulate metabolism, in anticipation of breakfast. Meanwhile, in the evening, your body temperature falls, and melatonin levels rise in anticipation of sleep. “The energy moving through your body is quite rhythmic,” says Young. Messing with this cellular schedule—staring at a bright light right before bed, for example—can throw these synchronized clocks out of whack.

As mentioned above, a disrupted cycle is often due to environmental factors, and can be cured with better sleep hygiene. But thanks to researchers like Young, we know that’s not always the case—not every individual’s circadian rhythm neatly aligns with external temperature and light cues. In the Cell study, one of the participant’s “habitual bedtime was at 3 a.m. or 4 a.m.,” with a “desired wakeup time between 10 a.m. and noon.” She tested positive for the CRY1 gene mutation, an indication that her internal clock was delayed in comparison with the normal population.

“You can imagine what that does to someone with a normal work schedule,” says Young. “They’re exhausted all the time.”


Wrangling genetics into a livable schedule

So what if you’re a night owl living in a world designed for early mornings? Young’s first suggestion is to figure out whether genetics are actually to blame (a CRY1 mutation can be determined by a spit test, as can other gene mutations linked to sleep disorders). Likely, part of the problem is tied to external, controllable factors, such as going to bed too late, or lying in the dark, staring at the glow from your smartphone. Or perhaps delayed sleep is a contained phase (college students have a tendency sleep in later than the adults they will grow up to become.)

But for individuals who “have a lifelong problem…something that persists and is seemingly hardwired into their biology” making adjustments is more difficult—but not impossible, says Young. One of the participants in the study, a lifelong night owl, tested positive for the CRY1 mutation; she also had a job that required her to wake up around 5 a.m. By sticking to a strict schedule—setting an alarm and waking up at 5 a.m., even on weekends—she was able to partially rewire her sleep-wake cycle. But as with individuals who are genetically predisposed to weight gain, maintaining a meaningful shift required constant vigilance. “If she lets her guard down, and sleeps in at a weekend, it produces all kind of problems,” says Young.

As with a diet, where meals and calories are tightly controlled, Young recommends late-sleepers adopt a schedule in which a variety of factors, including meals, bedtime, wake up time, and exposure to light, are regulated.

Circadian rhythm’s impact likely extends beyond sleep

The analogy to dieting is useful as circadian rhythm is “deeply involved in metabolic control,” says Young. While recreating a similar result in humans isn’t feasible, Young believes, as with sleep, our eating patterns evolved to align with cyclical fluctuations in the environment. Our ancestors’ meals were constricted by external factors, including daylight. Today, of course, that’s no longer the case. “We can switch on the light at any time and make a sandwich,” says Young, “A great amount of people eat around the clock,” says Young, which he believes could be a factor in America’s growing obesity crisis.

“We know that obesity has become a problem in the last century,” he says. Over that same period, our genes haven’t changed. Yes, the amount of calories—particularly via saturated-fats, refined grains, and sugar—has trended steadily upwards. But Young isn’t convinced that this, alone, is enough to explain the spike in our average BMI. Instead, changes in behavior, particularly the American tendency to snack consistently, including right before bed and, frequently, during the night, are also contributors.

Too often, in both sleep and appetite, our schedules are erratic. Modern life has enabled our internal clocks to fall out of whack with the earth’s cycle. Above everything else, Young recommends sticking to a schedule. “We were built to be rhythmic.”


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