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    Bill & Melinda Gates Foundation

It has been 15 years since the husband-and-wife team began their philanthropic mission to eradicate preventable diseases in developing nations. Since then their foundation has doled out nearly $33 billion in grants and made stunning progress toward its goals. New cases of malaria have decreased 25%, and India, after a Gates-backed vaccination campaign, said in 2014 that it was polio-free.