Keane is the first CEO of Synchrony Financial, the consumer finance business that was spun off from General Electric in the summer of 2014. She began as a debt collector at Citi, then rose through the ranks at GE to head the business that became Synchrony. The company reported net interest income of $11.3 billion at the end of 2014, and its stock price has risen 40% since the IPO.

For more on newcomers and returns to the list, read “Who’s on? Who’s off? Fortune’s list of the Most Powerful Women has plenty of changes.”